An analysis of harms reporting in systematic reviews regarding ketorolac for management of perioperative pain.

Humans Ketorolac / adverse effects Research Design Ketorolac Tromethamine Analgesics, Opioid Systematic Reviews as Topic Pain
cross-sectional analysis harms reporting ketorolac adverse effects ketorolac postoperative perioperative care perioperative ketorolac perioperative pain systematic reviews

Journal

British journal of anaesthesia
ISSN: 1471-6771
Titre abrégé: Br J Anaesth
Pays: England
ID NLM: 0372541

Informations de publication

Date de publication:
11 2022
Historique:
received: 27 06 2022
revised: 01 08 2022
accepted: 10 08 2022
pubmed: 30 9 2022
medline: 26 10 2022
entrez: 29 9 2022
Statut: ppublish

Résumé

Owing to the frequent perioperative use of ketorolac tromethamine and its ability to minimise postoperative opioid requirements, it is important to continually reassess harms associated with its use. Our primary objective was to investigate the extent of harms reporting in systematic reviews (SRs) on ketorolac for perioperative pain. In May 2022, we conducted a search of major databases, MEDLINE (PubMed and Ovid), Embase, Epistemonikos, and the Cochrane Database of Systematic Reviews to identify eligible SRs on ketorolac for perioperative pain. Screening and data extraction were performed in masked, duplicate fashion. A MeaSurement Tool to Assess systematic Reviews-2 (AMSTAR-2) was used to appraise the methodological quality of included SRs. Corrected covered area (CCA) was calculated to determine overlap of primary studies between SR dyads. A total of 28 SRs evaluating 630 primary studies met the inclusion criteria. Seven SRs (7/28, 25%) reported no harms and 17 SRs (17/28, 60.7%) reported ≤50% of harms items. A significant association was found between completeness of harms reporting and whether harms were specified as a primary outcome (P<0.001). No other associations were statistically significant. Regarding methodological quality, 22 SRs were appraised as 'critically low' (22/28, 78.6%), 5 as 'low' (5/28, 17.9%), and 1 as 'high' (1/28, 3.6%). One SR dyad had a CCA >50% but neither reported harms. The extent of harms reporting in systematic reviews was inadequate. Given the importance that systematic reviews have on guiding perioperative decision-making, it is essential to improve the completeness of harms reporting.

Sections du résumé

BACKGROUND
Owing to the frequent perioperative use of ketorolac tromethamine and its ability to minimise postoperative opioid requirements, it is important to continually reassess harms associated with its use. Our primary objective was to investigate the extent of harms reporting in systematic reviews (SRs) on ketorolac for perioperative pain.
METHODS
In May 2022, we conducted a search of major databases, MEDLINE (PubMed and Ovid), Embase, Epistemonikos, and the Cochrane Database of Systematic Reviews to identify eligible SRs on ketorolac for perioperative pain. Screening and data extraction were performed in masked, duplicate fashion. A MeaSurement Tool to Assess systematic Reviews-2 (AMSTAR-2) was used to appraise the methodological quality of included SRs. Corrected covered area (CCA) was calculated to determine overlap of primary studies between SR dyads.
RESULTS
A total of 28 SRs evaluating 630 primary studies met the inclusion criteria. Seven SRs (7/28, 25%) reported no harms and 17 SRs (17/28, 60.7%) reported ≤50% of harms items. A significant association was found between completeness of harms reporting and whether harms were specified as a primary outcome (P<0.001). No other associations were statistically significant. Regarding methodological quality, 22 SRs were appraised as 'critically low' (22/28, 78.6%), 5 as 'low' (5/28, 17.9%), and 1 as 'high' (1/28, 3.6%). One SR dyad had a CCA >50% but neither reported harms.
CONCLUSIONS
The extent of harms reporting in systematic reviews was inadequate. Given the importance that systematic reviews have on guiding perioperative decision-making, it is essential to improve the completeness of harms reporting.

Identifiants

DOI: 10.1016/j.bja.2022.08.007 PMID: 36175184
pubmed: 36175184
pii: S0007-0912(22)00449-4
doi: 10.1016/j.bja.2022.08.007
pii:
doi:

Substances chimiques

Ketorolac YZI5105V0L
Ketorolac Tromethamine 4EVE5946BQ
Analgesics, Opioid 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

767-775

Informations de copyright

Copyright © 2022 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.

Auteurs

Jay Modi (J)

Office of Medical Student Research, Oklahoma State University Center for Health Sciences, Tulsa, OK, USA. Electronic address: jay.modi@okstate.edu.

Trevor Magee (T)

Office of Medical Student Research, Oklahoma State University Center for Health Sciences, Tulsa, OK, USA.

Brayden Rucker (B)

Office of Medical Student Research, Oklahoma State University Center for Health Sciences, Tulsa, OK, USA.

Holly Flores (H)

Office of Medical Student Research, Oklahoma State University Center for Health Sciences, Tulsa, OK, USA.

Audrey Wise (A)

Office of Medical Student Research, Oklahoma State University Center for Health Sciences, Tulsa, OK, USA.

Micah Kee (M)

Office of Medical Student Research, Oklahoma State University Center for Health Sciences, Tulsa, OK, USA.

Morgan Garrett (M)

Office of Medical Student Research, Oklahoma State University Center for Health Sciences, Tulsa, OK, USA.

Will Roberts (W)

Department of Anesthesiology, Oklahoma State University Medical Center, Tulsa, OK, USA.

Matt Vassar (M)

Office of Medical Student Research, Oklahoma State University Center for Health Sciences, Tulsa, OK, USA; Department of Psychiatry and Behavioral Sciences, Oklahoma State University Center for Health Sciences, Tulsa, OK, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › An analysis of harms reporting in systematic...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Indoles › Indométacine › Kétorolac › An analysis of harms reporting in systematic...
questionsmedicales.fr › Disciplines des sciences naturelles › Science › Recherche › Plan de recherche › An analysis of harms reporting in systematic...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Indoles › Indométacine › Kétorolac trométhamine › An analysis of harms reporting in systematic...
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