Integrity of Neuronal Size in the Entorhinal Cortex Is a Biological Substrate of Exceptional Cognitive Aging.
Alzheimer's disease
SuperAging
entorhinal cortex
neurofibrillary tangles
neuronal integrity
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
09 11 2022
09 11 2022
Historique:
received:
05
04
2022
revised:
07
09
2022
accepted:
13
09
2022
pubmed:
1
10
2022
medline:
15
11
2022
entrez:
30
9
2022
Statut:
ppublish
Résumé
Average aging is associated with a gradual decline of memory capacity. SuperAgers are humans ≥80 years of age who show exceptional episodic memory at least as good as individuals 20-30 years their junior. This study investigated whether neuronal integrity in the entorhinal cortex (ERC), an area critical for memory and selectively vulnerable to neurofibrillary degeneration, differentiated SuperAgers from cognitively healthy younger individuals, cognitively average peers ("Normal Elderly"), and individuals with amnestic mild cognitive impairment. Postmortem sections of the ERC were stained with cresyl violet to visualize neurons and immunostained with mouse monoclonal antibody PHF-1 to visualize neurofibrillary tangles. The cross-sectional area (i.e., size) of layer II and layer III/V ERC neurons were quantified. Two-thirds of total participants were female. Unbiased stereology was used to quantitate tangles in a subgroup of SuperAgers and Normal Elderly. Linear mixed-effect models were used to determine differences across groups. Quantitative measurements found that the soma size of layer II ERC neurons in postmortem brain specimens were significantly larger in SuperAgers compared with all groups (
Identifiants
pubmed: 36180225
pii: JNEUROSCI.0679-22.2022
doi: 10.1523/JNEUROSCI.0679-22.2022
pmc: PMC9665923
doi:
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
8587-8594Subventions
Organisme : NIA NIH HHS
ID : F31 AG076318
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG067781
Pays : United States
Organisme : NINDS NIH HHS
ID : T32 NS047987
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG072977
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG062566
Pays : United States
Organisme : NIA NIH HHS
ID : R56 AG045571
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG013854
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG045571
Pays : United States
Organisme : NIA NIH HHS
ID : K08 AG065463
Pays : United States
Organisme : NIA NIH HHS
ID : U19 AG073153
Pays : United States
Informations de copyright
Copyright © 2022 the authors.
Références
J Am Geriatr Soc. 2014 Aug;62(8):1598-600
pubmed: 25116988
Cereb Cortex. 1993 Sep-Oct;3(5):465-75
pubmed: 7505138
Neurobiol Aging. 1992 May-Jun;13(3):375-82
pubmed: 1625766
Prog Brain Res. 2007;163:43-61
pubmed: 17765711
Ann Neurol. 1986 Oct;20(4):472-81
pubmed: 3789663
J Comp Neurol. 2013 Dec 15;521(18):4124-44
pubmed: 23852922
J Neurosci. 2000 Sep 1;20(17):6587-93
pubmed: 10964964
J Neurosci. 2016 Sep 14;36(37):9659-68
pubmed: 27629716
Neurology. 1993 Aug;43(8):1467-72
pubmed: 8350998
Front Aging Neurosci. 2019 May 14;11:94
pubmed: 31139072
Alzheimers Res Ther. 2020 Mar 2;12(1):21
pubmed: 32122400
Acta Neuropathol. 2022 Jul;144(1):27-44
pubmed: 35697880
JAMA. 2017 Apr 4;317(13):1373-1375
pubmed: 28384819
Prog Brain Res. 1990;83:445-57
pubmed: 2392569
J Neurosci. 2015 Jan 28;35(4):1781-91
pubmed: 25632151
Acta Neuropathol. 1985;68(4):325-32
pubmed: 4090943
J Comp Neurol. 1983 Feb 20;214(2):170-97
pubmed: 6841683
Acta Neuropathol. 1991;82(4):239-59
pubmed: 1759558
Cereb Cortex. 2021 Jun 10;31(7):3177-3183
pubmed: 33592091
Memory. 2016;24(1):75-88
pubmed: 25485974
Alzheimers Dement. 2011 May;7(3):270-9
pubmed: 21514249
Science. 1984 Sep 14;225(4667):1168-70
pubmed: 6474172
Curr Opin Neurol. 2021 Apr 1;34(2):258-265
pubmed: 33560671
Neurology. 2012 Aug 28;79(9):915-21
pubmed: 22895581
Alzheimers Res Ther. 2011 Nov 11;3(6):32
pubmed: 22078663
Cortex. 2018 Feb;99:69-77
pubmed: 29175073
Hippocampus. 2019 May;29(5):458-467
pubmed: 29341318
Nat Rev Neurosci. 2012 Mar 07;13(4):240-50
pubmed: 22395804
J Int Neuropsychol Soc. 2012 Nov;18(6):1081-5
pubmed: 23158231
Alzheimer Dis Assoc Disord. 2009 Apr-Jun;23(2):91-101
pubmed: 19474567
J Comp Neurol. 2000 Jul 3;422(3):396-401
pubmed: 10861515
J Cogn Neurosci. 2013 Jan;25(1):29-36
pubmed: 23198888
Eur Neurol. 1993;33(6):403-8
pubmed: 8307060
Neural Plast. 2008;2008:381243
pubmed: 18769556
J Neuropathol Exp Neurol. 2008 Dec;67(12):1205-12
pubmed: 19018241
J Neurosci Methods. 2007 Aug 15;164(1):19-26
pubmed: 17512605
Neurobiol Aging. 2006 Oct;27(10):1372-84
pubmed: 16289476
Neurology. 2015 Aug 11;85(6):535-42
pubmed: 26180144
Annu Rev Med. 1996;47:387-400
pubmed: 8712790
Cereb Cortex. 2018 Apr 1;28(4):1329-1337
pubmed: 28334147
Cereb Cortex. 1997 Dec;7(8):722-31
pubmed: 9408036
Neurology. 2018 Jan 30;90(5):e396-e403
pubmed: 29305438
J Hirnforsch. 1991;32(3):277-82
pubmed: 1779131