Transplantation to save the life, TSH screening to save the brain: A report and brief literature review of autoimmune thyroid disease after HSCT for severe combined immunodeficiency.
Autoimmunity
Hematopoietic stem cells transplantation
Infant
Severe combined immunodeficiency
Thyroid
Journal
Clinical immunology (Orlando, Fla.)
ISSN: 1521-7035
Titre abrégé: Clin Immunol
Pays: United States
ID NLM: 100883537
Informations de publication
Date de publication:
12 2022
12 2022
Historique:
received:
25
05
2022
revised:
07
09
2022
accepted:
10
09
2022
pubmed:
2
10
2022
medline:
26
11
2022
entrez:
1
10
2022
Statut:
ppublish
Résumé
Autoimmune thyroid disease has been described as a complication of HSCT for different indications and as a manifestation of inborn errors of immunity, like SCID. A 1-month female was diagnosed with RAG1-mutated SCID and received allogenic HSCT. She developed autoimmune hypothyroidism 5 months after transplantation and was treated with levo-thyroxine with a good response. Autoimmune thyroid disease can develop after HSCT during the immune reconstitution phase, leading to potentially severe neurological and growth impairment, particularly in SCID patients, often transplanted during the first year of life. Recommendations regarding early and frequent vigilance for thyroid function are needed in these patients.
Identifiants
pubmed: 36182049
pii: S1521-6616(22)00223-6
doi: 10.1016/j.clim.2022.109142
pii:
doi:
Substances chimiques
Thyrotropin
9002-71-5
Types de publication
Case Reports
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
109142Informations de copyright
Copyright © 2022. Published by Elsevier Inc.
Déclaration de conflit d'intérêts
Declaration of Competing Interest None of the authors has any potential financial conflict of interest related to this manuscript.