Genetic characterisation of the Theileria annulata cytochrome b locus and its impact on buparvaquone resistance in bovine.

Cattle Animals Theileria annulata / genetics Cytochromes b / genetics Phylogeny Theileriasis / drug therapy
Buparvaquone Hard selective sweep Soft selective sweep Theilieria annulata resistance

Journal

International journal for parasitology. Drugs and drug resistance
ISSN: 2211-3207
Titre abrégé: Int J Parasitol Drugs Drug Resist
Pays: Netherlands
ID NLM: 101576715

Informations de publication

Date de publication:
Dec 2022
Historique:
received: 11 07 2022
revised: 11 08 2022
accepted: 21 08 2022
pubmed: 3 10 2022
medline: 15 12 2022
entrez: 2 10 2022
Statut: ppublish

Résumé

Control of tropical theileriosis, caused by the apicomplexan Theileria annulata, depends on the use of a single drug, buparvaquone, the efficacy of which is compromised by the emergence of resistance. The present study was undertaken to improve understanding of the role of mutations conferring buparvaquone resistance in T. annulata, and the effects of selection pressures on their emergence and spread. First, we investigated genetic characteristics of the cytochrome b locus associated with buparvaquone resistance in 10 susceptible and 7 resistant T. annulata isolates. The 129G (GGC) mutation was found in the Q

Identifiants

DOI: 10.1016/j.ijpddr.2022.08.004 PMID: 36183440 PMC: PMC9529669
pubmed: 36183440
pii: S2211-3207(22)00021-5
doi: 10.1016/j.ijpddr.2022.08.004
pmc: PMC9529669
pii:
doi:

Substances chimiques

Cytochromes b 9035-37-4
buparvaquone 0354RT7LG4

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

65-75

Informations de copyright

Copyright © 2022. Published by Elsevier Ltd.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no competing interests.

Auteurs

Qasim Ali (Q)

Faculty of Veterinary and Animal Sciences, University of Agriculture, Dera Ismail Khan, Pakistan.

Osama Zahid (O)

Royal (Dick) School of Veterinary Studies, University of Edinburgh, UK.

Moez Mhadhbi (M)

Laboratoire de Parasitologie, École Nationale de Médecine Vétérinaire, Université de La Manouba, Sidi Thabet, Tunisia.

Ben Jones (B)

School of Veterinary Medicine, University of Surrey, UK.

Mohamed Aziz Darghouth (MA)

Laboratoire de Parasitologie, École Nationale de Médecine Vétérinaire, Université de La Manouba, Sidi Thabet, Tunisia.

George Raynes (G)

Royal (Dick) School of Veterinary Studies, University of Edinburgh, UK.

Kiran Afshan (K)

Department of Zoology, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.

Richard Birtles (R)

School of Science, Engineering and Environment, University of Salford, UK.

Neil D Sargison (ND)

Royal (Dick) School of Veterinary Studies, University of Edinburgh, UK.

Martha Betson (M)

School of Veterinary Medicine, University of Surrey, UK.

Umer Chaudhry (U)

School of Veterinary Medicine, University of Surrey, UK. Electronic address: u.chaudhry@surrey.ac.uk.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Ruminants › Bovins › Genetic characterisation of the Theileria...
questionsmedicales.fr › Eucaryotes › Animaux › Genetic characterisation of the Theileria...
questionsmedicales.fr › Eucaryotes › Alveolata › Apicomplexa › Piroplasmia › Piroplasmida › Theileria › Theileria annulata › Genetic characterisation of the Theileria...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Hémoprotéines › Cytochromes › Cytochromes de type b › Cytochromes b › Genetic characterisation of the Theileria...
questionsmedicales.fr › Sciences de l'information › Phylogenèse › Genetic characterisation of the Theileria...
questionsmedicales.fr › Maladies de l'animal › Parasitoses animales › Protozooses animales › Theilériose › Genetic characterisation of the Theileria...