Malabaricone C derived from nutmeg inhibits arachidonate 5-lipoxygenase activity and ameliorates psoriasis-like skin inflammation in mice.

Mice Animals Myristica / metabolism Arachidonate 5-Lipoxygenase / genetics Psoriasis / chemically induced Leukotrienes Platelet Activating Factor Inflammation
Anti-inflammation Arachidonate 5-lipoxygenase Leukotriene B(4) Malabaricone C Psoriasis

Journal

Free radical biology & medicine
ISSN: 1873-4596
Titre abrégé: Free Radic Biol Med
Pays: United States
ID NLM: 8709159

Informations de publication

Date de publication:
20 11 2022
Historique:
received: 04 07 2022
revised: 16 09 2022
accepted: 23 09 2022
pubmed: 3 10 2022
medline: 7 12 2022
entrez: 2 10 2022
Statut: ppublish

Résumé

As pro-inflammatory lipid mediators, leukotrienes have pathophysiological activities in several inflammatory diseases, including psoriasis. In the biosynthesis of leukotrienes from arachidonic acid, 5-lipoxygenase catalyzes the first two steps. In the present study, we showed that nutmeg (Myristica fragrans) strongly inhibited the catalytic activity of 5-lipoxygenase. To characterize the bioactive component(s) of nutmeg, we performed 5-lipoxygenase inhibitory activity-guided fractionation of aqueous ethanol extract of nutmeg, resulting in the isolation of malabaricone C having antioxidant activity. Malabaricone C exhibited potent competitive inhibition of 5-lipoxygenase with an IC

Identifiants

DOI: 10.1016/j.freeradbiomed.2022.09.028 PMID: 36183930
pubmed: 36183930
pii: S0891-5849(22)00618-9
doi: 10.1016/j.freeradbiomed.2022.09.028
pii:
doi:

Substances chimiques

Arachidonate 5-Lipoxygenase EC 1.13.11.34
malabaricone C 63335-25-1
Leukotrienes 0
Platelet Activating Factor 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1-8

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no competing interests.

Auteurs

Izumi Tsukayama (I)

Department of Nutritional Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama, 719-1197, Japan.

Yuki Kawakami (Y)

Department of Nutritional Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama, 719-1197, Japan.

Asako Tamenobu (A)

Department of Nutritional Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama, 719-1197, Japan.

Keisuke Toda (K)

Department of Nutritional Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama, 719-1197, Japan.

Saya Maruoka (S)

Department of Nutritional Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama, 719-1197, Japan.

Yuki Nagasaki (Y)

Department of Nutritional Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama, 719-1197, Japan.

Yoshiko Mori (Y)

Department of Nutritional Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama, 719-1197, Japan.

Risa Sawazumi (R)

Department of Nutritional Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama, 719-1197, Japan.

Kensuke Okamoto (K)

Department of Nutritional Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama, 719-1197, Japan.

Keita Kanzaki (K)

Department of Nutritional Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama, 719-1197, Japan.

Hideyuki Ito (H)

Department of Nutritional Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama, 719-1197, Japan.

Yoshitaka Takahashi (Y)

Department of Nutritional Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama, 719-1197, Japan.

Yoshimi Miki (Y)

Laboratory of Microenvironmental and Metabolic Health Sciences, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Kei Yamamoto (K)

Graduate School of Technology, Industrial and Social Science, Tokushima University, 2-1, Minami-jyosanjima-cho, Tokushima, 770-8513, Japan.

Makoto Murakami (M)

Laboratory of Microenvironmental and Metabolic Health Sciences, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Toshiko Suzuki-Yamamoto (T)

Department of Nutritional Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama, 719-1197, Japan. Electronic address: toshiko@fhw.oka-pu.ac.jp.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Malabaricone C derived from nutmeg inhibits...
questionsmedicales.fr › Eucaryotes › Animaux › Malabaricone C derived from nutmeg inhibits...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Myristicaceae › Myristica › Malabaricone C derived from nutmeg inhibits...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Métalloprotéines › Protéines de liaison au fer › Protéines à fer non hème › Lipoxygénases › Arachidonate lipoxygenases › Arachidonate 5-lipoxygenase › Malabaricone C derived from nutmeg inhibits...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Dermatoses papulosquameuses › Psoriasis › Malabaricone C derived from nutmeg inhibits...
questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Autacoïdes › Éicosanoïdes › Leucotriènes › Malabaricone C derived from nutmeg inhibits...
questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Autacoïdes › Facteur d'activation plaquettaire › Malabaricone C derived from nutmeg inhibits...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Malabaricone C derived from nutmeg inhibits...