Myeloid cell-derived catecholamines influence bone turnover and regeneration in mice.
Animals
Bone Remodeling
Bony Callus
/ metabolism
Catecholamines
/ metabolism
Fractures, Bone
/ metabolism
Interleukin-10
/ metabolism
Interleukin-4
/ metabolism
Interleukin-6
Macrophages
Male
Mice
Norepinephrine
Propranolol
RNA, Messenger
/ metabolism
Receptors, Adrenergic
/ metabolism
Tyrosine 3-Monooxygenase
X-Ray Microtomography
bone growth
bone metabolism
fracture healing
inflammation
tyrosine hydroxylase
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2022
2022
Historique:
received:
19
07
2022
accepted:
30
08
2022
entrez:
3
10
2022
pubmed:
4
10
2022
medline:
5
10
2022
Statut:
epublish
Résumé
Catecholamine signaling is known to influence bone tissue as reuptake of norepinephrine released from sympathetic nerves into bone cells declines with age leading to osteoporosis. Further, β-adrenoceptor-blockers like propranolol provoke osteoprotective effects in osteoporotic patients. However, besides systemic adrenal and sympathetic catecholamine production, it is also known that myeloid cells can synthesize catecholamines, especially under inflammatory conditions. To investigate the effects of catecholamines produced by CD11b
Identifiants
pubmed: 36187089
doi: 10.3389/fendo.2022.997745
pmc: PMC9520980
doi:
Substances chimiques
Catecholamines
0
Interleukin-6
0
RNA, Messenger
0
Receptors, Adrenergic
0
Interleukin-10
130068-27-8
Interleukin-4
207137-56-2
Propranolol
9Y8NXQ24VQ
Tyrosine 3-Monooxygenase
EC 1.14.16.2
Norepinephrine
X4W3ENH1CV
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
997745Informations de copyright
Copyright © 2022 Kuhn, Haffner-Luntzer, Kempter, Reber, Ichinose, Vacher, Ignatius and Tschaffon-Müller.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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