Dopamine D1 receptor and effort-based decision making in rats: The moderating effect of sex.

Animals Female Male Rats Conditioning, Operant Decision Making Dopamine / pharmacology Dopamine Antagonists / pharmacology Rats, Sprague-Dawley Receptors, Dopamine D1 / genetics Sex Characteristics
Amotivation D1 receptor Dopamine Effort-based decision-making Schizophrenia

Journal

Progress in neuro-psychopharmacology & biological psychiatry
ISSN: 1878-4216
Titre abrégé: Prog Neuropsychopharmacol Biol Psychiatry
Pays: England
ID NLM: 8211617

Informations de publication

Date de publication:
10 01 2023
Historique:
received: 18 04 2022
revised: 26 09 2022
accepted: 27 09 2022
pubmed: 4 10 2022
medline: 26 10 2022
entrez: 3 10 2022
Statut: ppublish

Résumé

Dopamine is a modulating factor in effort-based decision-making, and emerging evidence from pharmacological research suggests that the dopamine D1 receptor is the primary regulator. Given the limited selectivity of pharmacological tools, we further explored this hypothesis using dopamine D1 mutant (DAD1

Identifiants

DOI: 10.1016/j.pnpbp.2022.110651 PMID: 36191805
pubmed: 36191805
pii: S0278-5846(22)00143-9
doi: 10.1016/j.pnpbp.2022.110651
pii:
doi:

Substances chimiques

Dopamine VTD58H1Z2X
Dopamine Antagonists 0
Receptors, Dopamine D1 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

110651

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Auteurs

Kate M Witt (KM)

Behavioural Neurogenetics Group, Victoria University of Wellington, PO Box 600, Wellington, New Zealand.

David N Harper (DN)

Behavioural Neurogenetics Group, Victoria University of Wellington, PO Box 600, Wellington, New Zealand.

Bart A Ellenbroek (BA)

Behavioural Neurogenetics Group, Victoria University of Wellington, PO Box 600, Wellington, New Zealand. Electronic address: Bart.Ellenbroek@vuw.ac.nz.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Dopamine D1 receptor and effort-based decision...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Dopamine D1 receptor and effort-based decision...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Conditionnement (psychologie) › Conditionnement opérant › Dopamine D1 receptor and effort-based decision...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Pensée (activité mentale) › Prise de décision › Dopamine D1 receptor and effort-based decision...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Catéchols › Catécholamines › Dopamine › Dopamine D1 receptor and effort-based decision...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents dopaminergiques › Antagonistes de la dopamine › Dopamine D1 receptor and effort-based decision...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Sprague-Dawley › Dopamine D1 receptor and effort-based decision...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs catécholaminergiques › Récepteurs dopaminergiques › Récepteur dopamine D1 › Dopamine D1 receptor and effort-based decision...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Caractères sexuels › Dopamine D1 receptor and effort-based decision...