Hepatic inactivation of murine
Mice
Humans
Animals
Proprotein Convertase 9
/ genetics
RNA, Small Interfering
/ metabolism
HEK293 Cells
Mice, Inbred C57BL
Receptors, LDL
/ genetics
Liver
/ metabolism
Apolipoproteins B
/ metabolism
Lipoproteins
/ metabolism
Triglycerides
/ metabolism
Cholesterol
/ metabolism
Lipoproteins, LDL
/ metabolism
Membrane Proteins
/ genetics
APOB
PCSK9
SURF4
cell biology
cholesterol
mouse
secretion
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
04 Oct 2022
04 Oct 2022
Historique:
received:
09
08
2022
accepted:
03
10
2022
pubmed:
5
10
2022
medline:
22
10
2022
entrez:
4
10
2022
Statut:
epublish
Résumé
PCSK9 negatively regulates low-density lipoprotein receptor (LDLR) abundance on the cell surface, leading to decreased hepatic clearance of LDL particles and increased levels of plasma cholesterol. We previously identified SURF4 as a cargo receptor that facilitates PCSK9 secretion in HEK293T cells (Emmer et al., 2018). Here, we generated hepatic SURF4-deficient mice (
Identifiants
pubmed: 36193893
doi: 10.7554/eLife.82269
pii: 82269
pmc: PMC9581532
doi:
pii:
Substances chimiques
PCSK9 protein, human
EC 3.4.21.-
Proprotein Convertase 9
EC 3.4.21.-
RNA, Small Interfering
0
Receptors, LDL
0
Apolipoproteins B
0
Lipoproteins
0
Triglycerides
0
Cholesterol
97C5T2UQ7J
Lipoproteins, LDL
0
SURF4 protein, human
0
Membrane Proteins
0
Surf4 protein, mouse
0
Banques de données
GEO
['GSE214393']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NHLBI NIH HHS
ID : R35 HL135793
Pays : United States
Organisme : NHLBI NIH HHS
ID : K08 HL148552
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL157062
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL148333
Pays : United States
Informations de copyright
© 2022, Tang et al.
Déclaration de conflit d'intérêts
VT, JM, BX, YW, HF, XW, DS, RK, BE, XC, DG No competing interests declared
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