Intestinal Microbiota in Experimental Acute Kidney Injury.
Acute kidney injury
Gut microbiota
Inflammation
Ischemic-reperfusion injury
Journal
Nephron
ISSN: 2235-3186
Titre abrégé: Nephron
Pays: Switzerland
ID NLM: 0331777
Informations de publication
Date de publication:
2023
2023
Historique:
received:
05
05
2022
accepted:
26
07
2022
pmc-release:
01
01
2024
pubmed:
5
10
2022
medline:
15
2
2023
entrez:
4
10
2022
Statut:
ppublish
Résumé
Recent studies have demonstrated an important role played by gut microbiota in maintaining intestinal homeostasis and host immune system function. Gut microbiota have been studied in experimental acute kidney injury (AKI) using different mice and rat models exposed to either ischemia or cisplatin-mediated tubular injury. Differences in inflammatory markers and severity of AKI have been observed between germ-free mice, wild-type mice, and mice treated with antibiotics or specific bacteria. Interventions modifying the gut microbiota after experimental AKI have had either beneficial or harmful effects on kidney tubular injury and recovery. These findings provide strong evidence for a modulatory role of gut microbiota during AKI. Ischemic and cis-platin-induced AKI have distinct stool microbial signatures based on 16s sequencing. Future in-depth studies exploring the mechanisms of how the microbiota influence AKI and development of feasible therapeutic options have the potential to improve outcomes in clinical AKI.
Identifiants
pubmed: 36195072
pii: 000526265
doi: 10.1159/000526265
pmc: PMC9928605
mid: NIHMS1835416
doi:
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
25-30Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK123342
Pays : United States
Informations de copyright
© 2022 S. Karger AG, Basel.
Références
Kidney360. 2021 Jan 14;2(3):528-531
pubmed: 35369013
Am J Physiol Renal Physiol. 2009 Nov;297(5):F1457-65
pubmed: 19675178
Cell Metab. 2021 Oct 5;33(10):2091-2093
pubmed: 34614411
J Clin Invest. 2011 Nov;121(11):4210-21
pubmed: 22045571
Kidney Int. 2020 Oct;98(4):932-946
pubmed: 32470493
JCI Insight. 2018 Oct 18;3(20):
pubmed: 30333299
J Am Soc Nephrol. 2017 May;28(5):1450-1461
pubmed: 27927779
Int J Mol Med. 2020 Apr;45(4):1130-1140
pubmed: 32124946
Am J Physiol Renal Physiol. 2021 Oct 1;321(4):F455-F465
pubmed: 34423680
Metabolites. 2020 Apr 04;10(4):
pubmed: 32260384
Kidney Int. 2016 Mar;89(3):555-64
pubmed: 26880452
J Am Soc Nephrol. 2015 Aug;26(8):1877-88
pubmed: 25589612
Nutrients. 2021 Aug 15;13(8):
pubmed: 34444952