Humidified versus nonhumidified low-flow oxygen therapy in children with Pierre-Robin syndrome: A randomized controlled trial.
Journal
Medicine
ISSN: 1536-5964
Titre abrégé: Medicine (Baltimore)
Pays: United States
ID NLM: 2985248R
Informations de publication
Date de publication:
23 Sep 2022
23 Sep 2022
Historique:
entrez:
5
10
2022
pubmed:
6
10
2022
medline:
12
10
2022
Statut:
ppublish
Résumé
Humidification is an important process in clinical oxygen therapy. We aimed to evaluate the effects and safety of humidified versus nonhumidified low-flow oxygen therapy in children with Pierre-Robin syndrome. This study was an open-label, single-centered randomized controlled trial (RCT) with a parallel group design. The study protocol has been registered in Chinese Clinical Trial Registry (ChiCTR1900021584). The children were randomized to the humidified versus nonhumidified groups. Average arterial oxygen partial pressure (PaO2) and carbon dioxide partial pressure (PaCO2), incidence of ventilator-associated pneumonia (VAP), nasal cavity dryness, nasal mucosal bleeding and bacterial contamination of the humidified bottle, the cost of nasal oxygen therapy and duration of intensive care unit (ICU) stay were analyzed. A total of 213 children with Pierre-Robin syndrome were included. There were no significant differences in the gender, age, weight, prematurity, duration of anesthesia and surgery duration of mandibular traction between humidified group and nonhumidified group (all P > .05). No significant differences in the average arterial PaO2 and PaCO2 level on the postoperative day 1, 2, and ICU discharge between humidified group and nonhumidified group were found (all P > .05). There were no significant differences in the incidence of nasal cavity dryness, nasal mucosal bleeding, bacterial contamination and VAP, the duration of ICU stay between humidified group and nonhumidified group (all P > .05). The cost of nasal oxygen therapy in the humidified group was significantly less than that of nonhumidified group (P = .013). Humidifying the oxygen with cold sterile water in the low-flow oxygen therapy in children may be not necessary. Future RCTs with lager sample size and rigorous design are warranted to further elucidate the effects and safety of humidified versus nonhumidified low-flow oxygen therapy.
Sections du résumé
BACKGROUND
BACKGROUND
Humidification is an important process in clinical oxygen therapy. We aimed to evaluate the effects and safety of humidified versus nonhumidified low-flow oxygen therapy in children with Pierre-Robin syndrome.
METHODS
METHODS
This study was an open-label, single-centered randomized controlled trial (RCT) with a parallel group design. The study protocol has been registered in Chinese Clinical Trial Registry (ChiCTR1900021584). The children were randomized to the humidified versus nonhumidified groups. Average arterial oxygen partial pressure (PaO2) and carbon dioxide partial pressure (PaCO2), incidence of ventilator-associated pneumonia (VAP), nasal cavity dryness, nasal mucosal bleeding and bacterial contamination of the humidified bottle, the cost of nasal oxygen therapy and duration of intensive care unit (ICU) stay were analyzed.
RESULTS
RESULTS
A total of 213 children with Pierre-Robin syndrome were included. There were no significant differences in the gender, age, weight, prematurity, duration of anesthesia and surgery duration of mandibular traction between humidified group and nonhumidified group (all P > .05). No significant differences in the average arterial PaO2 and PaCO2 level on the postoperative day 1, 2, and ICU discharge between humidified group and nonhumidified group were found (all P > .05). There were no significant differences in the incidence of nasal cavity dryness, nasal mucosal bleeding, bacterial contamination and VAP, the duration of ICU stay between humidified group and nonhumidified group (all P > .05). The cost of nasal oxygen therapy in the humidified group was significantly less than that of nonhumidified group (P = .013).
CONCLUSIONS
CONCLUSIONS
Humidifying the oxygen with cold sterile water in the low-flow oxygen therapy in children may be not necessary. Future RCTs with lager sample size and rigorous design are warranted to further elucidate the effects and safety of humidified versus nonhumidified low-flow oxygen therapy.
Identifiants
pubmed: 36197167
doi: 10.1097/MD.0000000000030329
pii: 00005792-202209230-00013
pmc: PMC9509148
doi:
Substances chimiques
Water
059QF0KO0R
Carbon Dioxide
142M471B3J
Oxygen
S88TT14065
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
e30329Informations de copyright
Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.
Déclaration de conflit d'intérêts
The authors have no funding and conflicts of interest to disclose.
Références
Respir Care. 2013 Jan;58(1):98-122
pubmed: 23271822
Respir Care. 2013 Aug;58(8):1323-8
pubmed: 23287016
Nurs Crit Care. 2022 Mar;27(2):282-285
pubmed: 34476873
Semin Fetal Neonatal Med. 2021 Dec;26(6):101288
pubmed: 34688586
Zhonghua Yi Xue Za Zhi. 2017 May 30;97(20):1523-1525
pubmed: 28592054
Chest. 1988 Feb;93(2):289-93
pubmed: 3338294
Semin Fetal Neonatal Med. 2021 Dec;26(6):101285
pubmed: 34602353
Cleft Palate Craniofac J. 2020 Mar;57(3):344-351
pubmed: 31530001
J Clin Nurs. 2018 Mar;27(5-6):1125-1133
pubmed: 29076616
Chest. 2016 Aug;150(2):407-14
pubmed: 27048871
Arch Bronconeumol. 2021 Jan;57:77-79
pubmed: 34629673
Respir Care. 2017 May;62(5):532-537
pubmed: 28174331
BMJ. 2010 Mar 23;340:c332
pubmed: 20332509
Nihon Kokyuki Gakkai Zasshi. 2004 Feb;42(2):138-44
pubmed: 15007913
Am J Respir Crit Care Med. 2019 Feb 1;199(3):e5-e23
pubmed: 30707039
J Intensive Care Med. 2018 Nov;33(11):609-623
pubmed: 28429603
J Craniofac Surg. 2021 May 1;32(3):e288-e290
pubmed: 33181612
Sci Rep. 2021 Jul 12;11(1):14352
pubmed: 34253806
Fam Pract. 2007 Sep;24(4):295-301
pubmed: 17602176
J Adv Nurs. 2017 Nov;73(11):2522-2533
pubmed: 28440960
PLoS One. 2018 Aug 30;13(8):e0203332
pubmed: 30161225
Nihon Kyobu Shikkan Gakkai Zasshi. 1996 Nov;34(11):1189-93
pubmed: 8976072
J Clin Nurs. 2019 Oct;28(19-20):3522-3528
pubmed: 31162860
Respir Care. 2002 Jun;47(6):717-20
pubmed: 12078655
Paediatr Perinat Epidemiol. 2021 Sep;35(5):530-539
pubmed: 34132407
Clin Plast Surg. 2021 Jul;48(3):363-373
pubmed: 34051891
Plast Reconstr Surg. 2020 Nov;146(5):1103-1115
pubmed: 32826734
Arch Dis Child. 2021 Oct;106(10):954-960
pubmed: 34244167