Technical note: A method for generating lesion-specific nonuniform rotational margins for targets remote from isocenter.
margins
multiple metastases
radiosurgery
rotational uncertainties
stereotactic
Journal
Medical physics
ISSN: 2473-4209
Titre abrégé: Med Phys
Pays: United States
ID NLM: 0425746
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
revised:
27
08
2022
received:
30
11
2021
accepted:
04
09
2022
pubmed:
7
10
2022
medline:
28
12
2022
entrez:
6
10
2022
Statut:
ppublish
Résumé
To present a novel method for generating nonuniform lesion-specific rotational margins for targets remote from isocenter, as encountered in single isocenter multiple metastasis radiotherapy. Target contours are rotated using a large series of 3D rotations, corresponding to a given range of rotational uncertainty, and combined to create a rotational envelope that encompasses potential motion. A set of artificial spherical targets ranging from 0.5 to 2.0 cm in diameter, and residing a distance of 1 - 15 cm from isocenter, is used to generate rotational envelopes assuming uncertainties of 0.5-3.0°. Computing time and number of samples are reported for simulated scenarios. Hausdorff distances (HD) between rotational envelopes and original target structures are calculated to represent the magnitude of uniform expansion required to encompass potential rotation. Volume differences between uniform expansions (based on HD) and rotational envelopes are reported to articulate potential advantages. Median time to generate rotational envelopes was 60 s (31-974 s). Median required samples was 86 (61-851). Maximum HD for all targets located 10 cm from isocenter was 1.5 mm, 3.0 mm, 5.8 mm, and 8.6 mm assuming 0.5°, 1.0°, 2.0°, and 3.0° of rotational uncertainty, respectively. At 5 cm from isocenter and assuming 0.5° of rotational uncertainty, volumes were decreased by 0.07 cc (60%), 0.24 cc (39%), and 1.08 cc (19%) for 5 mm, 10 mm, and 20 mm targets respectively. At 10 cm from isocenter and 1.0° of uncertainty, volumes decreased by 0.42 cc (58%), 2.0 cc (40%), and 2.5 cc (27%). On average target volumes decreased 45% (SD = 17%) when compared with uniform expansions based on HD. Rotational margins may be generated by sampling a set of 3D rotations. Resulting margins explicitly account for target shape, distance from isocenter, and magnitude of rotational uncertainty, while reducing treated volumes when compared with uniform expansions.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
7438-7446Informations de copyright
© 2022 American Association of Physicists in Medicine.
Références
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