Impact of hormonal contraceptives on sex differences in fear conditioning and fear extinction in PTSD.
Journal
Learning & memory (Cold Spring Harbor, N.Y.)
ISSN: 1549-5485
Titre abrégé: Learn Mem
Pays: United States
ID NLM: 9435678
Informations de publication
Date de publication:
09 2022
09 2022
Historique:
received:
07
04
2022
accepted:
19
07
2022
entrez:
7
10
2022
pubmed:
8
10
2022
medline:
12
10
2022
Statut:
epublish
Résumé
Sex differences in the neurobiological mechanisms involved in fear conditioning and extinction have been suggested to contribute to differential vulnerability for the development of posttraumatic stress disorder (PTSD) in women compared with men. Reproductive hormones, such as estradiol, have been shown to facilitate fear conditioning and extinction learning and may explain some of these differences. However, the effect of commonly used hormonal contraceptives on the neurobiological mechanisms of fear conditioning and extinction is poorly understood. A laboratory study was conducted in trauma-exposed men and women with and without full or partial PTSD to examine effects of sex and use of hormonal birth control on fear conditioning, fear extinction learning, and extinction retention. Participants underwent fear conditioning with stimuli that were paired (CS+) or unpaired (CS-) with shock. Extinction learning occurred 72 h later, and extinction retention was tested 1 wk after extinction. Women on hormonal contraceptives (HCs) demonstrated enhanced acquisition of fear conditioning and enhanced extinction of fear as compared with women off hormonal birth control and men. While clinical implications have yet to be determined, these results suggest that hormonal contraceptives may facilitate learning during both fear acquisition and extinction. Understanding the impact of sex and hormones on fear conditioning and extinction processes may lead to new insights into the pathophysiology of PTSD and result in advancements in treatment that may vary by sex.
Identifiants
pubmed: 36206397
pii: 29/9/332
doi: 10.1101/lm.053597.122
pmc: PMC9488024
doi:
Substances chimiques
Contraceptive Agents
0
Estradiol
4TI98Z838E
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
332-339Subventions
Organisme : NCRR NIH HHS
ID : KL2 RR024130
Pays : United States
Informations de copyright
Published by Cold Spring Harbor Laboratory Press.
Références
Nat Rev Neurosci. 2015 Jan;16(1):17-29
pubmed: 25423896
Biol Psychiatry. 2015 Aug 1;78(3):178-85
pubmed: 25796471
NCHS Data Brief. 2020 Oct;(388):1-8
pubmed: 33151146
Physiol Behav. 2021 May 15;234:113372
pubmed: 33647267
PLoS One. 2018 May 15;13(5):e0197441
pubmed: 29763466
Neurobiol Learn Mem. 2018 Nov;155:403-411
pubmed: 30172954
J Abnorm Psychol. 2000 May;109(2):290-8
pubmed: 10895567
Front Psychol. 2020 Oct 27;11:556577
pubmed: 33224053
Hippocampus. 2009 Nov;19(11):1142-50
pubmed: 19338017
J Neuroendocrinol. 2020 Jan;32(1):e12800
pubmed: 31595559
Psychophysiology. 1981 May;18(3):232-9
pubmed: 7291438
J Pain. 2009 May;10(5):447-85
pubmed: 19411059
Brain Res. 1994 Oct 24;661(1-2):25-34
pubmed: 7834376
Biol Psychiatry. 2013 Feb 15;73(4):371-8
pubmed: 23158459
Psychol Trauma. 2022 Mar;14(3):453-461
pubmed: 35175083
J Clin Endocrinol Metab. 2017 Dec 1;102(12):4457-4466
pubmed: 29106594
Mol Psychiatry. 2018 Mar;23(3):658-665
pubmed: 28093566
Ann N Y Acad Sci. 2003 Dec;1008:112-21
pubmed: 14998877
Neuropsychopharmacology. 2022 Oct;47(11):1945-1952
pubmed: 34799682
Behav Res Ther. 2020 Jun;129:103615
pubmed: 32334278
Pharmacol Biochem Behav. 1999 Dec;64(4):753-9
pubmed: 10593198
Psychopharmacology (Berl). 1991;104(2):231-6
pubmed: 1876667
Neuropsychopharmacology. 2008 Jan;33(1):56-72
pubmed: 17882236
Arch Gen Psychiatry. 1998 Jul;55(7):626-32
pubmed: 9672053
Ther Adv Drug Saf. 2014 Oct;5(5):201-13
pubmed: 25360241
Neuroscience. 2009 Dec 15;164(3):887-95
pubmed: 19761818
Biol Mood Anxiety Disord. 2012 Feb 07;2:3
pubmed: 22738383
Cogn Affect Behav Neurosci. 2005 Jun;5(2):191-201
pubmed: 16180625
Psychoneuroendocrinology. 2013 Nov;38(11):2529-41
pubmed: 23790683
Biol Psychiatry. 2009 Dec 15;66(12):1075-82
pubmed: 19748076
Behav Neurosci. 2006 Dec;120(6):1196-203
pubmed: 17201462
Horm Behav. 2006 Feb;49(2):197-205
pubmed: 16083887
J Psychiatr Res. 2008 Jun;42(7):515-20
pubmed: 18313695
Mol Psychiatry. 2007 Feb;12(2):120-50
pubmed: 17160066
Brain Res. 2001 Jan 12;888(2):356-365
pubmed: 11150498
J Abnorm Psychol. 2016 Apr;125(3):349-55
pubmed: 26866677
J Psychiatry Neurosci. 2013 Sep;38(5):341-8
pubmed: 23611176
J Psychiatr Res. 2013 Jan;47(1):64-71
pubmed: 23107307
J Trauma Stress. 2015 Feb;28(1):1-7
pubmed: 25613589
Biol Psychiatry. 2012 Jul 1;72(1):19-24
pubmed: 22502987
BMC Psychiatry. 2015 Nov 18;15:295
pubmed: 26581193
Biol Psychiatry. 2011 Nov 15;70(10):920-7
pubmed: 21762880
J Neurosci Res. 2017 Jan 2;95(1-2):163-175
pubmed: 27870439
Neuroscience. 2010 Jul 14;168(3):652-8
pubmed: 20412837
J Trauma Stress. 1995 Jan;8(1):75-90
pubmed: 7712061
Curr Top Behav Neurosci. 2018;38:1-22
pubmed: 27830573
Psychophysiology. 2016 Sep;53(9):1377-85
pubmed: 27237725
Behav Brain Res. 2018 Oct 1;351:178-187
pubmed: 29885381
Climacteric. 2001 Dec;4(4):267-72
pubmed: 11770182
J Clin Psychiatry. 2000;61 Suppl 5:43-8; discussion 49-51
pubmed: 10761678