Characteristics associated with antenatally unidentified small-for-gestational-age fetuses: prospective cohort study nested within DESiGN randomized controlled trial.


Journal

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
ISSN: 1469-0705
Titre abrégé: Ultrasound Obstet Gynecol
Pays: England
ID NLM: 9108340

Informations de publication

Date de publication:
Mar 2023
Historique:
revised: 26 09 2022
received: 29 07 2022
accepted: 30 09 2022
pubmed: 8 10 2022
medline: 3 3 2023
entrez: 7 10 2022
Statut: ppublish

Résumé

To identify the clinical characteristics and patterns of ultrasound use amongst pregnancies with an antenatally unidentified small-for-gestational-age (SGA) fetus, compared with those in which SGA is identified, to understand how to design interventions that improve antenatal SGA identification. This was a prospective cohort study of singleton, non-anomalous SGA (birth weight < 10 Of the 15 784 SGA babies included, SGA was not identified antenatally in 78.7% of cases. Of pregnancies with unidentified SGA, 47.1% had no recorded growth scan. Amongst 9410 pregnancies with complete data on key maternal comorbidities and antenatal complications, the risk of unidentified SGA was lower for women with any indication for serial scans (adjusted odds ratio (aOR), 0.56 (95% CI, 0.49-0.64)), for Asian compared with white women (aOR, 0.80 (95% CI, 0.69-0.93)) and for those with non-cephalic presentation at birth (aOR, 0.58 (95% CI, 0.46-0.73)). The risk of unidentified SGA was highest among women with a body mass index (BMI) of 25.0-29.9 kg/m Unidentified SGA was more common amongst women without an indication for serial ultrasound, and in those with cephalic presentation at birth, BMI of 25.0-29.9 kg/m

Identifiants

pubmed: 36206546
doi: 10.1002/uog.26091
doi:

Types de publication

Randomized Controlled Trial Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

356-366

Subventions

Organisme : Medical Research Council
ID : MC_UU_00011/6
Pays : United Kingdom
Organisme : Stillborn and Neonatal Death Charity
ID : RG1011/16
Organisme : Tommy's Baby Charity
Organisme : Guy's and St Thomas' Charity
ID : MAJ150704

Investigateurs

Kirstie Coxon (K)
Andrew Healey (A)
Donald Peebles (D)
Baskaran Thilaganathan (B)
Neil Marlow (N)
Lesley McCowan (L)

Informations de copyright

© 2022 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.

Références

Every Woman Every Child: The Global Strategy for Women's, Children's and Adolescents' Health (2016-2030). https://www.everywomaneverychild.org/wp-content/uploads/2017/10/EWEC_GSUpdate_Brochure_EN_2017_web.pdf.
Gardosi J, Kady SM, McGeown P, Francis A, Tonks A. Classification of stillbirth by relevant condition at death (ReCoDe): population based cohort study. BMJ 2005; 331: 1113-1117.
Flenady V, Middleton P, Smith GC, Duke W, Erwich JJ, Khong TY, Neilson J, Ezzati M, Koopmans L, Ellwood D, Fretts R, Froen JF, Lancet's Stillbirths Series steering committee. Stillbirths: the way forward in high-income countries. Lancet 2011; 377: 1703-1717.
Gardosi J, Madurasinghe V, Williams M, Malik A, Francis A. Maternal and fetal risk factors for stillbirth: population based study. BMJ 2013; 346: f108.
Froen JF, Gardosi JO, Thurmann A, Francis A, Stray-Pedersen B. Restricted fetal growth in sudden intrauterine unexplained death. Acta Obstet Gynecol Scand 2004; 83: 801-807.
Efkarpidis S, Alexopoulos E, Kean L, Liu D, Fay T. Case-control study of factors associated with intrauterine fetal deaths. MedGenMed 2004; 6: 53.
Poon LC, Volpe N, Muto B, Syngelaki A, Nicolaides KH. Birthweight with gestation and maternal characteristics in live births and stillbirths. Fetal Diagn Ther 2012; 32: 156-165.
Iliodromiti S, Mackay DF, Smith GC, Pell JP, Sattar N, Lawlor DA, Nelson SM. Customised and Noncustomised Birth Weight Centiles and Prediction of Stillbirth and Infant Mortality and Morbidity: A Cohort Study of 979 912 Term Singleton Pregnancies in Scotland. PLoS Med 2017; 14: e1002228.
Flenady V, Wojcieszek AM, Middleton P, Ellwood D, Erwich JJ, Coory M, Khong TY, Silver RM, Smith GC, Boyle FM, Lawn JE, Blencowe H, Leisher SH, Gross MM, Horey D, Farrales L, Bloomfield F, McCowan L, Brown SJ, Joseph KS, Zeitlin J, Reinebrant HE, Ravaldi C, Vannacci A, Cassidy J, Cassidy P, Farquhar C, Wallace E, Siassakos D, Heazell AE, Storey C, Sadler L, Petersen S, Froen JF, Goldenberg RL, Lancet Ending Preventable Stillbirths study group, Lancet Stillbirths In High-Income Countries Investigator Group. Stillbirths: recall to action in high-income countries. Lancet 2016; 387: 691-702.
McCowan LM, Figueras F, Anderson NH. Evidence-based national guidelines for the management of suspected fetal growth restriction: comparison, consensus, and controversy. Am J Obstet Gynecol 2018; 218: S855-868.
Backe B, Nakling J. Effectiveness of antenatal care: a population based study. Br J Obstet Gynaecol 1993; 100: 727-732.
Monier I, Blondel B, Ego A, Kaminiski M, Goffinet F, Zeitlin J. Poor effectiveness of antenatal detection of fetal growth restriction and consequences for obstetric management and neonatal outcomes: a French national study. BJOG 2015; 122: 518-527.
Jahn A, Razum O, Berle P. Routine screening for intrauterine growth retardation in Germany: low sensitivity and questionable benefit for diagnosed cases. Acta Obstet Gynecol Scand 1998; 77: 643-648.
Mattioli KP, Sanderson M, Chauhan SP. Inadequate identification of small-for-gestational-age fetuses at an urban teaching hospital. Int J Gynaecol Obstet 2010; 109: 140-143.
Kean LH, Liu DTY. Antenatal care as a screening tool for the detection of small for gestational age babies in the low risk population. J Obstet Gynaecol 1996; 16: 77-82.
Chauhan SP, Beydoun H, Chang E, Sandlin AT, Dahlke JD, Igwe E, Magann EF, Anderson KR, Abuhamad AZ, Ananth CV. Prenatal detection of fetal growth restriction in newborns classified as small for gestational age: correlates and risk of neonatal morbidity. Am J Perinatol 2014; 31: 187-194.
Fratelli N, Valcamonico A, Prefumo F, Pagani G, Guarneri T, Frusca T. Effects of antenatal recognition and follow-up on perinatal outcomes in small-for-gestational age infants delivered after 36 weeks. Acta Obstet Gynecol Scand 2013; 92: 223-229.
Lindqvist PG, Molin J. Does antenatal identification of small-for-gestational age fetuses significantly improve their outcome? Ultrasound Obstet Gynecol 2005; 25: 258-264.
Andreasen LA, Tabor A, Norgaard LN, Taksoe-Vester CA, Krebs L, Jorgensen FS, Jepsen IE, Sharif H, Zingenberg H, Rosthoj S, Sorensen AL, Tolsgaard MG. Why we succeed and fail in detecting fetal growth restriction: A population-based study. Acta Obstet Gynecol Scand 2021; 100: 893-899.
Diksha P, Permezel M, Pritchard N. Why we miss fetal growth restriction: Identification of risk factors for severely growth-restricted fetuses remaining undelivered by 40 weeks' gestation. Aust N Z J Obstet Gynaecol 2018; 58: 674-680.
Vieira MC, Relph S, Muruet-Gutierrez W, Elstad M, Coker B, Moitt N, Delaney L, Winsloe C, Healey A, Coxon K, Alagna A, Briley A, Johnson M, Page LM, Peebles D, Shennan A, Thilaganathan B, Marlow N, McCowan L, Lees C, Lawlor DA, Khalil A, Sandall J, Copas A, Pasupathy D, Group DEC. Evaluation of the Growth Assessment Protocol (GAP) for antenatal detection of small for gestational age: The DESiGN cluster randomised trial. PLoS Med 2022; 19: e1004004.
Relph S, Vieira MC, Copas A, Coxon K, Alagna A, Briley A, Johnson M, Page L, Peebles D, Shennan A, Thilaganathan B, Marlow N, Lees C, Lawlor DA, Khalil A, Sandall J, Pasupathy D, Healey A; DESiGN Trial Team. Improving antenatal detection of small-for-gestational-age fetus: economic evaluation of Growth Assessment Protocol. Ultrasound Obstet Gynecol 2022; 60: 620-631.
Vieira MC, Relph S, Copas A, Healey A, Coxon K, Alagna A, Briley A, Johnson M, Lawlor DA, Lees C, Marlow N, McCowan L, Page L, Peebles D, Shennan A, Thilaganathan B, Khalil A, Sandall J, Pasupathy D; DESiGN Collaborative Group . The DESiGN trial (DEtection of Small for Gestational age Neonate), evaluating the effect of the Growth Assessment Protocol (GAP): study protocol for a randomised controlled trial. Trials 2019; 20: 154.
Relph S, Elstad M, Coker B, Vieira MC, Moitt N, Gutierrez WM, Khalil A, Sandall J, Copas A, Lawlor DA, Pasupathy D, team DT. Using electronic patient records to assess the effect of a complex antenatal intervention in a cluster randomised controlled trial-data management experience from the DESiGN Trial team. Trials 2021; 22: 195.
Cole TJ, Freeman JV, Preece MA. British 1990 growth reference centiles for weight, height, body mass index and head circumference fitted by maximum penalized likelihood. Stat Med 1998; 17: 407-429.
Pinnock H, Barwick M, Carpenter CR, Eldridge S, Grandes G, Griffiths CJ, Rycroft-Malone J, Meissner P, Murray E, Patel A, Sheikh A, Taylor SJ, Sta RIG. Standards for Reporting Implementation Studies (StaRI) Statement. BMJ 2017; 356: i6795.
Hadlock FP, Harrist RB, Martinez-Poyer J. In utero analysis of fetal growth: a sonographic weight standard. Radiology 1991; 181: 129-133.
Rubin D. Multiple imputation for nonresponse in surveys. Wiley & Sons: New York, NY, 1987.
NHS England. Saving Babies' Lives Version Two. https://www.england.nhs.uk/wp-content/uploads/2019/07/saving-babies-lives-care-bundle-version-two-v5.pdf.
Goto E. Prediction of low birthweight and small for gestational age from symphysis-fundal height mainly in developing countries: a meta-analysis. J Epidemiol Community Health 2013; 67: 999-1005.
Royal College of Obstetricians & Gynaecologists. Small for Gestational Age Fetus: Investigation & Management. Green-top Guideline No. 31. https://www.rcog.org.uk/guidance/browse-all-guidance/green-top-guidelines/small-for-gestational-age-fetus-investigation-and-management-green-top-guideline-no-31/.
Caradeux J, Martinez-Portilla RJ, Peguero A, Sotiriadis A, Figueras F. Diagnostic performance of third-trimester ultrasound for the prediction of late-onset fetal growth restriction: a systematic review and meta-analysis. Am J Obstet Gynecol 2019; 220: 449-459.e19.
Stampalija T, Wolf H, Mylrea-Foley B, Marlow N, Stephens KJ, Shaw CJ, Lees CC; TRUFFLE-2 Feasibility Study authors. Reduced fetal growth velocity and weight loss are associated with adverse perinatal outcome in fetuses at risk of growth restriction. Am J Obstet Gynecol 2023; 228: e1-10.
Stephens K, Al-Memar M, Beattie-Jones S, Dhanjal M, Mappouridou S, Thorne E, Lees C. Comparing the relation between ultrasound-estimated fetal weight and birthweight in cohort of small-for-gestational-age fetuses. Acta Obstet Gynecol Scand 2019; 98: 1435-1441.
National Institute for Health and Care Excellence. Antenatal care for uncomplicated pregnancies. https://www.nice.org.uk/Guidance/CG62.
Smith GC, Moraitis AA, Wastlund D, Thornton JG, Papageorghiou A, Sanders J, Heazell AE, Robson SC, Sovio U, Brocklehurst P, Wilson EC. Universal late pregnancy ultrasound screening to predict adverse outcomes in nulliparous women: a systematic review and cost-effectiveness analysis. Health Technol Assess 2021; 25: 1-190.
Preyer O, Husslein H, Concin N, Ridder A, Musielak M, Pfeifer C, Oberaigner W, Husslein P. Fetal weight estimation at term - ultrasound versus clinical examination with Leopold's manoeuvres: a prospective blinded observational study. BMC Pregnancy Childbirth 2019; 19: 122.
Fox NS, Rebarber A, Silverstein M, Roman AS, Klauser CK, Saltzman DH. The effectiveness of antepartum surveillance in reducing the risk of stillbirth in patients with advanced maternal age. Eur J Obstet Gynecol Reprod Biol 2013; 170: 387-390.
Aksoy H, Aksoy U, Karadag OI, Yucel B, Aydin T, Babayigit MA. Influence of maternal body mass index on sonographic fetal weight estimation prior to scheduled delivery. J Obstet Gynaecol Res 2015; 41: 1556-1561.
Kajdy A, Modzelewski J, Jakubiak M, Pokropek A, Rabijewski M. Effect of antenatal detection of small-for-gestational-age newborns in a risk stratified retrospective cohort. PLoS One 2019; 14: e0224553.
NHS England. Saving Babies' Lives: A care bundle for reducing stillbirth. 2016. www.england.nhs.uk/wp-content/uploads/2016/03/saving-babies-lives-car-bundl.pdf.
National Institute for Health and Care Excellence. Hypertension in pregnancy: diagnosis and management. https://www.nice.org.uk/guidance/ng133.
Relph S, Coxon K, Vieira MC, Copas A, Healey A, Alagna A, Briley A, Johnson M, Lawlor DA, Lees C, Marlow N, McCowan L, McMicking J, Page L, Peebles D, Shennan A, Thilaganathan B, Khalil A, Pasupathy D, Sandall J; DESiGN Collaborative Group. Effect of the Growth Assessment Protocol on the DEtection of the Small for GestatioNal Age Fetus: Process evaluation from the DESiGN cluster randomised trial. Implement Sci 2022; 17: 60.
Williams M, Turner S, Butler E, Gardosi J. Fetal growth surveillance - Current guidelines, practices and challenges. Ultrasound 2018; 26: 69-79.
Hugh O, Williams M, Turner S, Gardosi J. Reduction of stillbirths in England from 2008 to 2017 according to uptake of the Growth Assessment Protocol: 10-year population-based cohort study. Ultrasound Obstet Gynecol 2021; 57: 401-408.
Jayawardena L, Sheehan P. Introduction of a customised growth chart protocol increased detection of small for gestational age pregnancies in a tertiary Melbourne hospital. Aust N Z J Obstet Gynaecol 2019; 59: 493-500.
Cowan FJ, McKinlay CJD, Taylor RS, Wilson J, McAra-Couper J, Garrett N, O'Brien A, McCowan LME. Detection of small for gestational age babies and perinatal outcomes following implementation of the Growth Assessment Protocol at a New Zealand tertiary facility: an observational intervention study. Aust N Z J Obstet Gynaecol 2021; 61: 339-346.
Stubert J, Peschel A, Bolz M, Glass A, Gerber B. Accuracy of immediate antepartum ultrasound estimated fetal weight and its impact on mode of delivery and outcome - a cohort analysis. BMC Pregnancy Childbirth 2018; 18: 118.
Francis A, Tonks A, Gardosi J. Accuracy of ultrasound estimation of fetal weight at term. Arch Dis Child Fetal Neonatal Ed 2011; 96: Fa61.
Milner J, Arezina J. The accuracy of ultrasound estimation of fetal weight in comparison to birth weight: a systematic review. Ultrasound 2018; 26: 32-41.
Castro-Vasquez BA, Taboada C. Accuracy of Estimated Fetal Weight in Third Trimester [33A]. Obstet Gynecol 2020; 135: 16S-17S.

Auteurs

S Relph (S)

Department of Women and Children's Health, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.

M C Vieira (MC)

Department of Women and Children's Health, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.
Department of Obstetrics and Gynaecology, School of Medical Sciences, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.

A Copas (A)

Centre for Pragmatic Global Health Trials, Institute for Global Health, University College London, London, UK.

A Alagna (A)

The Guy's & St Thomas' Charity, London, UK.

L Page (L)

West Middlesex University Hospital, Chelsea & Westminster Hospital NHS Foundation Trust, Isleworth, UK.

C Winsloe (C)

Department of Women and Children's Health, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.
Centre for Pragmatic Global Health Trials, Institute for Global Health, University College London, London, UK.

A Shennan (A)

Department of Women and Children's Health, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.

A Briley (A)

Department of Women and Children's Health, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.
Caring Futures Institute, Flinders University and North Adelaide Local Health Network, Adelaide, Australia.

M Johnson (M)

Department of Surgery and Cancer, Imperial College London, London, UK.

C Lees (C)

Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.

D A Lawlor (DA)

Population Health Science, Bristol Medical School, University of Bristol, Bristol, UK.
Bristol NIHR Biomedical Research Centre, Bristol, UK.
MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.

J Sandall (J)

Department of Women and Children's Health, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.

A Khalil (A)

Fetal Medicine Unit, St George's University Hospitals NHS Foundation Trust, London, UK.
Vascular Biology Research Centre, Molecular & Clinical Sciences Research Institute, St George's University of London, London, UK.

D Pasupathy (D)

Department of Women and Children's Health, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.
Reproduction and Perinatal Centre, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.

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