Correspondence between gene expression and neurotransmitter receptor and transporter density in the human brain.
Journal
NeuroImage
ISSN: 1095-9572
Titre abrégé: Neuroimage
Pays: United States
ID NLM: 9215515
Informations de publication
Date de publication:
01 12 2022
01 12 2022
Historique:
received:
11
07
2022
revised:
29
09
2022
accepted:
05
10
2022
pubmed:
10
10
2022
medline:
15
12
2022
entrez:
9
10
2022
Statut:
ppublish
Résumé
Neurotransmitter receptors modulate signaling between neurons. Thus, neurotransmitter receptors and transporters play a key role in shaping brain function. Due to the lack of comprehensive neurotransmitter receptor/transporter density datasets, microarray gene expression measuring mRNA transcripts is often used as a proxy for receptor densities. In the present report, we comprehensively test the spatial correlation between gene expression and protein density for a total of 27 neurotransmitter receptors, receptor binding-sites, and transporters across 9 different neurotransmitter systems, using both PET and autoradiography radioligand-based imaging modalities. We find poor spatial correspondences between gene expression and density for all neurotransmitter receptors and transporters except four single-protein metabotropic receptors (5-HT
Identifiants
pubmed: 36209794
pii: S1053-8119(22)00792-3
doi: 10.1016/j.neuroimage.2022.119671
pii:
doi:
Substances chimiques
Receptors, Neurotransmitter
0
Neurotransmitter Agents
0
Carrier Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
119671Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.