Exercise MR-proANP unmasks latent right heart failure in CTEPH.

Humans Atrial Natriuretic Factor Hypertension, Pulmonary / etiology Prospective Studies Heart Failure Exercise Biomarkers
CTEPH MR-proANP cardiac biomarkers exercise testing right heart failure

Journal

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
ISSN: 1557-3117
Titre abrégé: J Heart Lung Transplant
Pays: United States
ID NLM: 9102703

Informations de publication

Date de publication:
12 2022
Historique:
received: 06 04 2022
revised: 31 07 2022
accepted: 22 08 2022
pubmed: 10 10 2022
medline: 30 11 2022
entrez: 9 10 2022
Statut: ppublish

Résumé

The present study was designed to investigate the dynamics of right atrial pressure (RAP) and mid-regional pro-atrial natriuretic peptide (MR-proANP) during physical exercise in patients with chronic thromboembolic pulmonary hypertension (CTEPH) and to determine whether these parameters might serve as a tool to measure exercise-dependent atrial stress as an indicator of right heart failure. This prospective observational cohort study included 100 CTEPH patients who underwent right heart catheterization during physical exercise (eRHC). Blood samples for MR-proANP measurement were taken prior, during, and after eRHC. MR-proANP levels were correlated to RAP levels at rest, at peak exercise (eRAP), and during recovery. RAP at rest ≤7 mmHg was defined as normal and eRAP >15 mmHg as suggestive of right heart failure. During eRHC mean RAP increased from 6 mmHg (standard deviation, SD 4) to 16 mmHg (SD 7; p < 0.001). MR-proANP levels and dynamics correlated with RAP at rest (r RAP and MR-proANP dynamics unmask manifest and latent right heart failure in CTEPH patients.

Identifiants

DOI: 10.1016/j.healun.2022.08.017 PMID: 36210266
pubmed: 36210266
pii: S1053-2498(22)02084-8
doi: 10.1016/j.healun.2022.08.017
pii:
doi:

Substances chimiques

Atrial Natriuretic Factor 85637-73-6
Biomarkers 0

Types de publication

Observational Study Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1819-1830

Informations de copyright

Copyright © 2022 International Society for Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved.

Auteurs

Steffen D Kriechbaum (SD)

Campus Kerckhoff, University of Giessen, Heart and Thorax Center, Department of Cardiology, Bad Nauheim, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Bad Nauheim, Germany. Electronic address: s.kriechbaum@kerckhoff-klinik.de.

Judith Birmes (J)

Campus Kerckhoff, University of Giessen, Heart and Thorax Center, Department of Cardiology, Bad Nauheim, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Bad Nauheim, Germany.

Christoph B Wiedenroth (CB)

Campus Kerckhoff, University of Giessen, Heart and Thorax Center, Department of Thoracic Surgery, Bad Nauheim, Germany.

Miriam S D Adameit (MSD)

Campus Kerckhoff, University of Giessen, Heart and Thorax Center, Department of Thoracic Surgery, Bad Nauheim, Germany.

Dimitri Gruen (D)

Justus Liebig University Giessen, Medical Clinic I, Division of Cardiology, Giessen, Germany.

J Vietheer (J)

Campus Kerckhoff, University of Giessen, Heart and Thorax Center, Department of Cardiology, Bad Nauheim, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Bad Nauheim, Germany.

Manuel J Richter (MJ)

Department of Pneumology, Kerckhoff-Klinik, Bad Nauheim, Germany; Department of Internal Medicine, Justus Liebig University Giessen, Universities of Giessen and Marburg Lung Center (UGMLC), member of the German Center for Lung Research (DZL), Giessen, Germany.

Stefan Guth (S)

Campus Kerckhoff, University of Giessen, Heart and Thorax Center, Department of Thoracic Surgery, Bad Nauheim, Germany.

Fritz C Roller (FC)

Justus Liebig University Giessen, Department of Radiology, Giessen, Germany.

Matthias Rademann (M)

Campus Kerckhoff, University of Giessen, Heart and Thorax Center, Department of Cardiology, Bad Nauheim, Germany.

Ulrich Fischer-Rasokat (U)

Campus Kerckhoff, University of Giessen, Heart and Thorax Center, Department of Cardiology, Bad Nauheim, Germany; Justus Liebig University Giessen, Medical Clinic I, Division of Cardiology, Giessen, Germany.

Andreas Rolf (A)

Campus Kerckhoff, University of Giessen, Heart and Thorax Center, Department of Cardiology, Bad Nauheim, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Bad Nauheim, Germany; Justus Liebig University Giessen, Medical Clinic I, Division of Cardiology, Giessen, Germany.

Christoph Liebetrau (C)

Campus Kerckhoff, University of Giessen, Heart and Thorax Center, Department of Cardiology, Bad Nauheim, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Bad Nauheim, Germany; Cardioangiologisches Centrum Bethanien, Frankfurt am Main, Germany.

Christian W Hamm (CW)

Campus Kerckhoff, University of Giessen, Heart and Thorax Center, Department of Cardiology, Bad Nauheim, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Bad Nauheim, Germany; Justus Liebig University Giessen, Medical Clinic I, Division of Cardiology, Giessen, Germany.

Till Keller (T)

Campus Kerckhoff, University of Giessen, Heart and Thorax Center, Department of Cardiology, Bad Nauheim, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Bad Nauheim, Germany; Justus Liebig University Giessen, Medical Clinic I, Division of Cardiology, Giessen, Germany.

Andreas J Rieth (AJ)

Campus Kerckhoff, University of Giessen, Heart and Thorax Center, Department of Cardiology, Bad Nauheim, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Bad Nauheim, Germany.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Exercise MR-proANP unmasks latent right heart...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Peptides natriurétiques › Facteur atrial natriurétique › Exercise MR-proANP unmasks latent right heart...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Hypertension artérielle › Hypertension pulmonaire › Exercise MR-proANP unmasks latent right heart...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Exercise MR-proANP unmasks latent right heart...
questionsmedicales.fr › Maladies cardiovasculaires › Cardiopathies › Défaillance cardiaque › Exercise MR-proANP unmasks latent right heart...
questionsmedicales.fr › Activités humaines › Exercice physique › Exercise MR-proANP unmasks latent right heart...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Exercise MR-proANP unmasks latent right heart...