Child Neurology: Familial Hemophagocytic Lymphohistiocytosis Underlying Isolated CNS Inflammation.

Brain Diseases Child Encephalitis / complications Humans Inflammation Lymphohistiocytosis, Hemophagocytic / complications Neurology

Journal

Neurology
ISSN: 1526-632X
Titre abrégé: Neurology
Pays: United States
ID NLM: 0401060

Informations de publication

Date de publication:
11 10 2022
Historique:
received: 18 03 2022
accepted: 01 07 2022
entrez: 10 10 2022
pubmed: 11 10 2022
medline: 13 10 2022
Statut: ppublish

Résumé

Encephalitis and encephalopathy in children represent a diagnostic challenge. We describe a patient with relapsing encephalitis in whom the differential diagnosis included acute disseminated encephalomyelitis, human herpesvirus 6 encephalitis, and hemophagocytic lymphohistiocytosis (HLH). Because of its rarity, HLH is often overlooked as a differential diagnosis in encephalitis, especially in the isolated CNS forms. As this case illustrates, inborn errors of immunity can underlie isolated encephalitis and should be included in the differential diagnosis of these presentations.

Identifiants

DOI: 10.1212/WNL.0000000000201124 PMID: 36216522
pubmed: 36216522
pii: WNL.0000000000201124
doi: 10.1212/WNL.0000000000201124
doi:

Types de publication

Case Reports Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

660-664

Informations de copyright

© 2022 American Academy of Neurology.

Auteurs

Giorgia Bucciol (G)

From the Department of Pediatrics (G.B., N.W., K.J., L.D.W., I.M.), Radiology (B.V.) and Laboratory Medicine (X.B., K.L.), and Center for Human Genetics (A.C.), Leuven University Hospitals; Laboratory of Inborn Errors of Immunity (G.B., I.M.), Departments of Microbiology, Immunology and Transplantation, Laboratory of Clinical Microbiology (K.L.), Department of Microbiology, Immunology and Transplantation, and Development and Regeneration (K.J., L.D.W.), KU Leuven, Belgium; Department of Pediatric Immunology (D.M.), Hematology and Rheumatology, Necker-Enfants Malades Hospital, APHP, Paris; and Imagine Institute, Inserm U1163, Université Paris Cité, France. giorgia.bucciol@uzleuven.be.

Nele Willemyns (N)

From the Department of Pediatrics (G.B., N.W., K.J., L.D.W., I.M.), Radiology (B.V.) and Laboratory Medicine (X.B., K.L.), and Center for Human Genetics (A.C.), Leuven University Hospitals; Laboratory of Inborn Errors of Immunity (G.B., I.M.), Departments of Microbiology, Immunology and Transplantation, Laboratory of Clinical Microbiology (K.L.), Department of Microbiology, Immunology and Transplantation, and Development and Regeneration (K.J., L.D.W.), KU Leuven, Belgium; Department of Pediatric Immunology (D.M.), Hematology and Rheumatology, Necker-Enfants Malades Hospital, APHP, Paris; and Imagine Institute, Inserm U1163, Université Paris Cité, France.

Benjamin Verhaaren (B)

From the Department of Pediatrics (G.B., N.W., K.J., L.D.W., I.M.), Radiology (B.V.) and Laboratory Medicine (X.B., K.L.), and Center for Human Genetics (A.C.), Leuven University Hospitals; Laboratory of Inborn Errors of Immunity (G.B., I.M.), Departments of Microbiology, Immunology and Transplantation, Laboratory of Clinical Microbiology (K.L.), Department of Microbiology, Immunology and Transplantation, and Development and Regeneration (K.J., L.D.W.), KU Leuven, Belgium; Department of Pediatric Immunology (D.M.), Hematology and Rheumatology, Necker-Enfants Malades Hospital, APHP, Paris; and Imagine Institute, Inserm U1163, Université Paris Cité, France.

Xavier Bossuyt (X)

From the Department of Pediatrics (G.B., N.W., K.J., L.D.W., I.M.), Radiology (B.V.) and Laboratory Medicine (X.B., K.L.), and Center for Human Genetics (A.C.), Leuven University Hospitals; Laboratory of Inborn Errors of Immunity (G.B., I.M.), Departments of Microbiology, Immunology and Transplantation, Laboratory of Clinical Microbiology (K.L.), Department of Microbiology, Immunology and Transplantation, and Development and Regeneration (K.J., L.D.W.), KU Leuven, Belgium; Department of Pediatric Immunology (D.M.), Hematology and Rheumatology, Necker-Enfants Malades Hospital, APHP, Paris; and Imagine Institute, Inserm U1163, Université Paris Cité, France.

Katrien Lagrou (K)

From the Department of Pediatrics (G.B., N.W., K.J., L.D.W., I.M.), Radiology (B.V.) and Laboratory Medicine (X.B., K.L.), and Center for Human Genetics (A.C.), Leuven University Hospitals; Laboratory of Inborn Errors of Immunity (G.B., I.M.), Departments of Microbiology, Immunology and Transplantation, Laboratory of Clinical Microbiology (K.L.), Department of Microbiology, Immunology and Transplantation, and Development and Regeneration (K.J., L.D.W.), KU Leuven, Belgium; Department of Pediatric Immunology (D.M.), Hematology and Rheumatology, Necker-Enfants Malades Hospital, APHP, Paris; and Imagine Institute, Inserm U1163, Université Paris Cité, France.

Anniek Corveleyn (A)

From the Department of Pediatrics (G.B., N.W., K.J., L.D.W., I.M.), Radiology (B.V.) and Laboratory Medicine (X.B., K.L.), and Center for Human Genetics (A.C.), Leuven University Hospitals; Laboratory of Inborn Errors of Immunity (G.B., I.M.), Departments of Microbiology, Immunology and Transplantation, Laboratory of Clinical Microbiology (K.L.), Department of Microbiology, Immunology and Transplantation, and Development and Regeneration (K.J., L.D.W.), KU Leuven, Belgium; Department of Pediatric Immunology (D.M.), Hematology and Rheumatology, Necker-Enfants Malades Hospital, APHP, Paris; and Imagine Institute, Inserm U1163, Université Paris Cité, France.

Despina Moshous (D)

From the Department of Pediatrics (G.B., N.W., K.J., L.D.W., I.M.), Radiology (B.V.) and Laboratory Medicine (X.B., K.L.), and Center for Human Genetics (A.C.), Leuven University Hospitals; Laboratory of Inborn Errors of Immunity (G.B., I.M.), Departments of Microbiology, Immunology and Transplantation, Laboratory of Clinical Microbiology (K.L.), Department of Microbiology, Immunology and Transplantation, and Development and Regeneration (K.J., L.D.W.), KU Leuven, Belgium; Department of Pediatric Immunology (D.M.), Hematology and Rheumatology, Necker-Enfants Malades Hospital, APHP, Paris; and Imagine Institute, Inserm U1163, Université Paris Cité, France.

Katrien Jansen (K)

From the Department of Pediatrics (G.B., N.W., K.J., L.D.W., I.M.), Radiology (B.V.) and Laboratory Medicine (X.B., K.L.), and Center for Human Genetics (A.C.), Leuven University Hospitals; Laboratory of Inborn Errors of Immunity (G.B., I.M.), Departments of Microbiology, Immunology and Transplantation, Laboratory of Clinical Microbiology (K.L.), Department of Microbiology, Immunology and Transplantation, and Development and Regeneration (K.J., L.D.W.), KU Leuven, Belgium; Department of Pediatric Immunology (D.M.), Hematology and Rheumatology, Necker-Enfants Malades Hospital, APHP, Paris; and Imagine Institute, Inserm U1163, Université Paris Cité, France.

Liesbeth De Waele (L)

From the Department of Pediatrics (G.B., N.W., K.J., L.D.W., I.M.), Radiology (B.V.) and Laboratory Medicine (X.B., K.L.), and Center for Human Genetics (A.C.), Leuven University Hospitals; Laboratory of Inborn Errors of Immunity (G.B., I.M.), Departments of Microbiology, Immunology and Transplantation, Laboratory of Clinical Microbiology (K.L.), Department of Microbiology, Immunology and Transplantation, and Development and Regeneration (K.J., L.D.W.), KU Leuven, Belgium; Department of Pediatric Immunology (D.M.), Hematology and Rheumatology, Necker-Enfants Malades Hospital, APHP, Paris; and Imagine Institute, Inserm U1163, Université Paris Cité, France.

Isabelle Meyts (I)

From the Department of Pediatrics (G.B., N.W., K.J., L.D.W., I.M.), Radiology (B.V.) and Laboratory Medicine (X.B., K.L.), and Center for Human Genetics (A.C.), Leuven University Hospitals; Laboratory of Inborn Errors of Immunity (G.B., I.M.), Departments of Microbiology, Immunology and Transplantation, Laboratory of Clinical Microbiology (K.L.), Department of Microbiology, Immunology and Transplantation, and Development and Regeneration (K.J., L.D.W.), KU Leuven, Belgium; Department of Pediatric Immunology (D.M.), Hematology and Rheumatology, Necker-Enfants Malades Hospital, APHP, Paris; and Imagine Institute, Inserm U1163, Université Paris Cité, France.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Maladies du système nerveux › Maladies du système nerveux central › Encéphalopathies › Child Neurology: Familial Hemophagocytic...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Child Neurology: Familial Hemophagocytic...
questionsmedicales.fr › Maladies du système nerveux › Encéphalite › Child Neurology: Familial Hemophagocytic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Child Neurology: Familial Hemophagocytic...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Child Neurology: Familial Hemophagocytic...
questionsmedicales.fr › Hémopathies et maladies lymphatiques › Maladies lymphatiques › Histiocytose › Histiocytose non langerhansienne › Lymphohistiocytose hémophagocytaire › Child Neurology: Familial Hemophagocytic...
questionsmedicales.fr › Professions de santé › Médecine › Neurologie › Child Neurology: Familial Hemophagocytic...