MDA-LDL vaccination induces athero-protective germinal-center-derived antibody responses.
B cell
CP: Immunology
MDA-LDL
antibody
atherosclerosis
germinal center
vaccine
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
11 10 2022
11 10 2022
Historique:
received:
31
03
2022
revised:
13
08
2022
accepted:
19
09
2022
entrez:
12
10
2022
pubmed:
13
10
2022
medline:
15
10
2022
Statut:
ppublish
Résumé
Atherosclerosis is a chronic inflammatory disease of the arteries that can lead to thrombosis, infarction, and stroke and is the leading cause of mortality worldwide. Immunization of pro-atherogenic mice with malondialdehyde-modified low-density lipoprotein (MDA-LDL) neo-antigen is athero-protective. However, the immune response to MDA-LDL and the mechanisms responsible for this athero-protection are not completely understood. Here, we find that immunization of mice with MDA-LDL elicits memory B cells, plasma cells, and switched anti-MDA-LDL antibodies as well as clonal expansion and affinity maturation, indicating that MDA-LDL triggers a bona fide germinal center antibody response. Further, Prdm1
Identifiants
pubmed: 36223741
pii: S2211-1247(22)01318-3
doi: 10.1016/j.celrep.2022.111468
pii:
doi:
Substances chimiques
Lipoproteins, LDL
0
Vaccines
0
Malondialdehyde
4Y8F71G49Q
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
111468Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.