Discovery of fusidic acid derivatives as novel STING inhibitors for treatment of sepsis.
Anti-inflammatory
Fusidic acid
STING inhibitor
Sepsis
Journal
European journal of medicinal chemistry
ISSN: 1768-3254
Titre abrégé: Eur J Med Chem
Pays: France
ID NLM: 0420510
Informations de publication
Date de publication:
15 Dec 2022
15 Dec 2022
Historique:
received:
25
07
2022
revised:
28
09
2022
accepted:
29
09
2022
pubmed:
14
10
2022
medline:
22
11
2022
entrez:
13
10
2022
Statut:
ppublish
Résumé
Sepsis is often caused by systemic inflammatory responses. Stimulator of interferon genes (STING) could be a promising treatment target for sepsis. In this study, we report the design and synthesis of a new series of fusidic acid derivatives. Among the synthesized derivatives, the promising compound 30 inhibited lipopolysaccharide (LPS)-induced nitric oxide production in macrophages with an IC
Identifiants
pubmed: 36228412
pii: S0223-5234(22)00716-4
doi: 10.1016/j.ejmech.2022.114814
pii:
doi:
Substances chimiques
Fusidic Acid
59XE10C19C
Lipopolysaccharides
0
NF-kappa B
0
STING1 protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
114814Informations de copyright
Copyright © 2022 Elsevier Masson SAS. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.