Bioprosthetic Total Artificial Heart Implantation Does Not Induce Chronic Inflammation.
Journal
ASAIO journal (American Society for Artificial Internal Organs : 1992)
ISSN: 1538-943X
Titre abrégé: ASAIO J
Pays: United States
ID NLM: 9204109
Informations de publication
Date de publication:
01 11 2022
01 11 2022
Historique:
pubmed:
14
10
2022
medline:
8
11
2022
entrez:
13
10
2022
Statut:
ppublish
Résumé
The Aeson total artificial heart (A-TAH) has been developed for patients at risk of death from biventricular failure. We aimed to assess the inflammatory status in nine subjects implanted with the A-TAH in kinetics over one year. Laboratory assessment of leukocyte counts, inflammatory cytokines assay, and peripheral blood mononuclear cell collection before and after A-TAH implantation. Leukocyte counts were not significantly modulated according to time after A-TAH implantation (coefficient of the linear mixed effect model with 95% CI, -0.05 (-0.71 to -0.61); p = 0.44). We explored inflammatory cytokine after A-TAH and did not observe, at any time, a modified profile compared to pre-implantation values (all p -values > 0.05). Finally, we compared the distribution of circulating immune cell subpopulations identified based on sequential expression patterns for multiple clusters of differentiation. None of the population explored had significant modulation during the 12-month follow-up (all p -values > 0.05). In conclusion, using a cytokine multiplex assay combined with a flow cytometry approach, we demonstrated the absence of inflammatory signals in peripheral blood over a period of 12 months following A-TAH implantation.
Identifiants
pubmed: 36228635
doi: 10.1097/MAT.0000000000001820
pii: 00002480-202211000-00006
doi:
Substances chimiques
Cytokines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e173-e178Informations de copyright
Copyright © ASAIO 2022.
Déclaration de conflit d'intérêts
D.M.S., P.I., Y.P. and I.N. received consulting fees from CARMAT. C.P., C.L., A.C. and P.J. are employed by CARMAT-SAS. Other authors have no conflicts of interest to report.
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