Inhibition of Pyruvate Dehydrogenase Kinase 4 in CD4

Animals Mice Calcium / metabolism CD4-Positive T-Lymphocytes / metabolism Colitis / chemically induced Inflammation / pathology Mice, Knockout T-Lymphocytes / metabolism Gene Deletion
Inflammatory Bowel Disease Mitochondria-Associated ER Membrane Pyruvate Dehydrogenase Kinase

Journal

Cellular and molecular gastroenterology and hepatology
ISSN: 2352-345X
Titre abrégé: Cell Mol Gastroenterol Hepatol
Pays: United States
ID NLM: 101648302

Informations de publication

Date de publication:
2023
Historique:
received: 17 03 2022
revised: 28 09 2022
accepted: 29 09 2022
pubmed: 14 10 2022
medline: 25 1 2023
entrez: 13 10 2022
Statut: ppublish

Résumé

Despite recent evidence supporting the metabolic plasticity of CD4 To investigate the role of PDK4 in colitis, we used dextran sulfate sodium (DSS)-induced colitis and T-cell transfer colitis models based on mice with constitutive knockout (KO) or CD4 Expression of PDK4 increased during colitis development in a DSS-induced colitis model. Phosphorylated PDHE1α, a substrate of PDK4, accumulated in CD4 PDK4 deletion from CD4

Sections du résumé

BACKGROUND & AIMS OBJECTIVE
Despite recent evidence supporting the metabolic plasticity of CD4
METHODS METHODS
To investigate the role of PDK4 in colitis, we used dextran sulfate sodium (DSS)-induced colitis and T-cell transfer colitis models based on mice with constitutive knockout (KO) or CD4
RESULTS RESULTS
Expression of PDK4 increased during colitis development in a DSS-induced colitis model. Phosphorylated PDHE1α, a substrate of PDK4, accumulated in CD4
CONCLUSIONS CONCLUSIONS
PDK4 deletion from CD4

Identifiants

DOI: 10.1016/j.jcmgh.2022.09.016 PMID: 36229019 PMC: PMC9791136
pubmed: 36229019
pii: S2352-345X(22)00211-9
doi: 10.1016/j.jcmgh.2022.09.016
pmc: PMC9791136
pii:
doi:

Substances chimiques

Calcium SY7Q814VUP
pyruvate dehydrogenase kinase 4 EC 2.7.1.-

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

439-461

Informations de copyright

Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.

Auteurs

Hoyul Lee (H)

Research Institute of Aging and Metabolism, Kyungpook National University, Daegu, Republic of Korea.

Jae Han Jeon (JH)

Research Institute of Aging and Metabolism, Kyungpook National University, Daegu, Republic of Korea; Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Chilgok Hospital, Daegu, Republic of Korea.

Yu-Jeong Lee (YJ)

Cell & Matrix Research Institute, Kyungpook National University, Daegu, Republic of Korea.

Mi-Jin Kim (MJ)

Research Institute of Aging and Metabolism, Kyungpook National University, Daegu, Republic of Korea.

Woong Hee Kwon (WH)

Leading-Edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease, Kyungpook National University Hospital, Daegu, Republic of Korea.

Dipanjan Chanda (D)

Research Institute of Aging and Metabolism, Kyungpook National University, Daegu, Republic of Korea.

Themis Thoudam (T)

Research Institute of Aging and Metabolism, Kyungpook National University, Daegu, Republic of Korea.

Haushabhau S Pagire (HS)

Department of Chemistry, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea.

Suvarna H Pagire (SH)

Department of Chemistry, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea.

Jin Hee Ahn (JH)

Department of Chemistry, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea.

Robert A Harris (RA)

Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas.

Eun Soo Kim (ES)

Division of Gastroenterology, Department of Internal Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Republic of Korea. Electronic address: dandy813@hanmail.net.

In-Kyu Lee (IK)

Research Institute of Aging and Metabolism, Kyungpook National University, Daegu, Republic of Korea; Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Republic of Korea. Electronic address: leei@knu.ac.kr.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Inhibition of Pyruvate Dehydrogenase Kinase 4 in CD4
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Inhibition of Pyruvate Dehydrogenase Kinase 4 in CD4
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Calcium › Inhibition of Pyruvate Dehydrogenase Kinase 4 in CD4
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD4+ › Inhibition of Pyruvate Dehydrogenase Kinase 4 in CD4
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies du côlon › Colite › Inhibition of Pyruvate Dehydrogenase Kinase 4 in CD4
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Inhibition of Pyruvate Dehydrogenase Kinase 4 in CD4
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Inhibition of Pyruvate Dehydrogenase Kinase 4 in CD4
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Inhibition of Pyruvate Dehydrogenase Kinase 4 in CD4
questionsmedicales.fr › Phénomènes génétiques › Mutagenèse › Délétion de séquence › Délétion de gène › Inhibition of Pyruvate Dehydrogenase Kinase 4 in CD4