Regulation of Airway Smooth Muscle Cell Proliferation by Diacylglycerol Kinase: Relevance to Airway Remodeling in Asthma.
Airway Remodeling
Animals
Asthma
/ metabolism
Cell Proliferation
Cyclin D1
/ metabolism
Diacylglycerol Kinase
/ genetics
Diglycerides
/ metabolism
Humans
Inositol
/ pharmacology
Mice
Mitogens
/ pharmacology
Myocytes, Smooth Muscle
/ metabolism
Phosphatidic Acids
/ metabolism
Platelet-Derived Growth Factor
/ metabolism
Protein-Tyrosine Kinases
/ metabolism
Receptors, G-Protein-Coupled
/ metabolism
TOR Serine-Threonine Kinases
/ metabolism
Type C Phospholipases
/ metabolism
airway remodeling
airway smooth muscle
asthma
diacylglycerol kinase
proliferation
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
06 Oct 2022
06 Oct 2022
Historique:
received:
18
08
2022
revised:
27
09
2022
accepted:
03
10
2022
entrez:
14
10
2022
pubmed:
15
10
2022
medline:
18
10
2022
Statut:
epublish
Résumé
Airway remodeling in asthma involves the hyperproliferation of airway smooth muscle (ASM) cells. However, the molecular signals that regulate ASM growth are not completely understood. Gq-coupled G protein-coupled receptor and receptor tyrosine kinase signaling regulate ASM cell proliferation via activation of phospholipase C, generation of inositol triphosphate (IP
Identifiants
pubmed: 36233170
pii: ijms231911868
doi: 10.3390/ijms231911868
pmc: PMC9569455
pii:
doi:
Substances chimiques
Diglycerides
0
Mitogens
0
Phosphatidic Acids
0
Platelet-Derived Growth Factor
0
Receptors, G-Protein-Coupled
0
Cyclin D1
136601-57-5
Inositol
4L6452S749
Diacylglycerol Kinase
EC 2.7.1.107
Protein-Tyrosine Kinases
EC 2.7.10.1
TOR Serine-Threonine Kinases
EC 2.7.11.1
Type C Phospholipases
EC 3.1.4.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL058506
Pays : United States
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