Structure Activity Relationship Studies around

Humans Models, Molecular Molecular Docking Simulation Molecular Structure Protein Kinase Inhibitors / chemistry Structure-Activity Relationship
CLK-kinases DYRK1A kinase cytotoxicity kinases molecular modelling quinazoline

Journal

Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009

Informations de publication

Date de publication:
20 Sep 2022
Historique:
received: 26 08 2022
revised: 14 09 2022
accepted: 15 09 2022
entrez: 14 10 2022
pubmed: 15 10 2022
medline: 18 10 2022
Statut: epublish

Résumé

Three series of our lead CLK1 inhibitor

Identifiants

DOI: 10.3390/molecules27196149 PMID: 36234686 PMC: PMC9571063
pubmed: 36234686
pii: molecules27196149
doi: 10.3390/molecules27196149
pmc: PMC9571063
pii:
doi:

Substances chimiques

Protein Kinase Inhibitors 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Références

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Auteurs

Dabbugoddu Brahmaiah (D)

Chemveda Life Sciences India Pvt. Ltd., #B-11/1, IDA Uppal, Hyderabad-500039, Telangana, India.
Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad-500 085, Telangana, India.

Anagani Kanaka Durga Bhavani (AKD)

Department of Chemistry, Osmania University, Hyderabad 500007, Telangana, India.

Pasula Aparna (P)

Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad-500 085, Telangana, India.

Nangunoori Sampath Kumar (NS)

Chemveda Life Sciences India Pvt. Ltd., #B-11/1, IDA Uppal, Hyderabad-500039, Telangana, India.

Hélène Solhi (H)

Univ Rennes, PlateformImPACcell, BIOSIT, F-35000 Rennes, France.

Rémy Le Guevel (R)

Univ Rennes, PlateformImPACcell, BIOSIT, F-35000 Rennes, France.

Blandine Baratte (B)

Sorbonne Université, CNRS, FR 2424, Plateforme de criblage KISSf (Kinase Inhibitor Specialized Screening facility), Station Biologique de Roscoff, CS 90074, 29688 Roscoff Cedex, France.
Sorbonne Université, CNRS, UMR 8227, Integrative Biology of Marine Models Laboratory (LBI2M), Station Biologique de Roscoff, CS 90074, 29688 Roscoff Cedex, France.
ORCID: 0000-0002-2064-9558

Thomas Robert (T)

Sorbonne Université, CNRS, FR 2424, Plateforme de criblage KISSf (Kinase Inhibitor Specialized Screening facility), Station Biologique de Roscoff, CS 90074, 29688 Roscoff Cedex, France.
Sorbonne Université, CNRS, UMR 8227, Integrative Biology of Marine Models Laboratory (LBI2M), Station Biologique de Roscoff, CS 90074, 29688 Roscoff Cedex, France.

Sandrine Ruchaud (S)

Sorbonne Université, CNRS, UMR 8227, Integrative Biology of Marine Models Laboratory (LBI2M), Station Biologique de Roscoff, CS 90074, 29688 Roscoff Cedex, France.
ORCID: 0000-0002-4606-6625

Stéphane Bach (S)

Sorbonne Université, CNRS, FR 2424, Plateforme de criblage KISSf (Kinase Inhibitor Specialized Screening facility), Station Biologique de Roscoff, CS 90074, 29688 Roscoff Cedex, France.
Sorbonne Université, CNRS, UMR 8227, Integrative Biology of Marine Models Laboratory (LBI2M), Station Biologique de Roscoff, CS 90074, 29688 Roscoff Cedex, France.
Centre of Excellence for Pharmaceutical Sciences, North-West University, Private Bag X6001, Potchefstroom 2520, South Africa.
ORCID: 0000-0002-7186-7483

Surender Singh Jadav (SS)

CSIR-Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad 500007, TS, India.
ORCID: 0000-0002-5397-8956

Chada Raji Reddy (CR)

CSIR-Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad 500007, TS, India.

Paul Mosset (P)

Univ Rennes, CNRS, ISCR (Institut des Sciences Chimiques de Rennes), UMR 6226, F-35000 Rennes, France.

Nicolas Gouault (N)

Univ Rennes, CNRS, ISCR (Institut des Sciences Chimiques de Rennes), UMR 6226, F-35000 Rennes, France.

Nicolas Levoin (N)

Bioprojet-Biotech, 4 rue du Chesnay Beauregard, BP 96205, 35762 Saint Grégoire, France.
ORCID: 0000-0002-7731-736X

René Grée (R)

Univ Rennes, CNRS, ISCR (Institut des Sciences Chimiques de Rennes), UMR 6226, F-35000 Rennes, France.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Structure Activity Relationship Studies around
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › Structure Activity Relationship Studies around
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Structure Activity Relationship Studies around
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Structure Activity Relationship Studies around
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de protéines kinases › Structure Activity Relationship Studies around
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Structure Activity Relationship Studies around