Discovery of Novel Boron-Containing

Amino Acids / pharmacology Animals Antiviral Agents / chemistry Boron / pharmacology Boronic Acids / pharmacology Drug Resistance, Viral Enzyme Inhibitors / pharmacology Influenza A Virus, H1N1 Subtype / metabolism Influenza A Virus, H5N1 Subtype Influenza A virus / metabolism Mice Molecular Docking Simulation Neuraminidase Oseltamivir / analogs & derivatives
150-cavity boronic acid influenza neuraminidase inhibitors oseltamivir derivatives

Journal

Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009

Informations de publication

Date de publication:
29 Sep 2022
Historique:
received: 06 09 2022
revised: 22 09 2022
accepted: 26 09 2022
entrez: 14 10 2022
pubmed: 15 10 2022
medline: 18 10 2022
Statut: epublish

Résumé

To address drug resistance to influenza virus neuraminidase inhibitors (NAIs), a series of novel boron-containing

Identifiants

DOI: 10.3390/molecules27196426 PMID: 36234966 PMC: PMC9571049
pubmed: 36234966
pii: molecules27196426
doi: 10.3390/molecules27196426
pmc: PMC9571049
pii:
doi:

Substances chimiques

Amino Acids 0
Antiviral Agents 0
Boronic Acids 0
Enzyme Inhibitors 0
Oseltamivir 20O93L6F9H
Neuraminidase EC 3.2.1.18
oseltamivir carboxylate K6106LV5Q8
Boron N9E3X5056Q

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : National Natural Science Foundation of China
ID : NSFC no. 81773574
Organisme : Shandong Provincial Key research and development project
ID : 2019JZZY021011
Organisme : Science Foundation for Outstanding Young Scholars of Shandong Province
ID : ZR2020JQ31
Organisme : Foreign cultural and educational experts Project
ID : GXL20200015001
Organisme : Shandong modern agricultural technology & industry system
ID : SDAIT-21-06
Organisme : Agricultural scientific and technological innovation project of Shandong Academy of Agricultural Sciences
ID : CXGC2021A12
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : grants IG 2016 - ID. 18855 and IG 2021 - ID. 25899
Organisme : British Society for Antimicrobial Chemotherapy
ID : BSAC-2018-0064
Organisme : Ministero dell'Istruzione, dell'Università e della Ricerca
ID : PRIN 2017-cod. 2017KM79NN

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Auteurs

Ruifang Jia (R)

Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, Jinan 250012, China.

Jiwei Zhang (J)

Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, Jinan 250012, China.

Jian Zhang (J)

Institute of Medical Sciences, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250033, China.

Chiara Bertagnin (C)

Department of Molecular Medicine, University of Padova, Via Gabelli 63, 35121 Padova, Italy.
ORCID: 0000-0003-2985-3392

Anna Bonomini (A)

Department of Molecular Medicine, University of Padova, Via Gabelli 63, 35121 Padova, Italy.
ORCID: 0000-0001-9022-9551

Laura Guizzo (L)

Department of Molecular Medicine, University of Padova, Via Gabelli 63, 35121 Padova, Italy.

Zhen Gao (Z)

Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, Jinan 250012, China.

Xiangkai Ji (X)

Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, Jinan 250012, China.

Zhuo Li (Z)

Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, Jinan 250012, China.

Chuanfeng Liu (C)

Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, Jinan 250012, China.

Han Ju (H)

Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, Jinan 250012, China.

Xiuli Ma (X)

Institute of Poultry Science, Shandong Academy of Agricultural Sciences, 1 Jiaoxiao Road, Jinan 250023, China.

Arianna Loregian (A)

Department of Molecular Medicine, University of Padova, Via Gabelli 63, 35121 Padova, Italy.
ORCID: 0000-0002-8900-861X

Bing Huang (B)

Institute of Poultry Science, Shandong Academy of Agricultural Sciences, 1 Jiaoxiao Road, Jinan 250023, China.

Peng Zhan (P)

Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, Jinan 250012, China.
China-Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province, 44 West Culture Road, Jinan 250012, China.

Xinyong Liu (X)

Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, Jinan 250012, China.
China-Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province, 44 West Culture Road, Jinan 250012, China.
ORCID: 0000-0002-7302-2214

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Discovery of Novel Boron-Containing
questionsmedicales.fr › Eucaryotes › Animaux › Discovery of Novel Boron-Containing
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiviraux › Discovery of Novel Boron-Containing
questionsmedicales.fr › Produits chimiques inorganiques › Éléments › Métalloïdes › Bore › Discovery of Novel Boron-Containing
questionsmedicales.fr › Composés chimiques organiques › Composés du bore › Acides boroniques › Discovery of Novel Boron-Containing
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance microbienne aux médicaments › Résistance virale aux médicaments › Discovery of Novel Boron-Containing
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Discovery of Novel Boron-Containing
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN de polarité négative › Orthomyxoviridae › Influenzavirus A › Virus de la grippe A › Sous-type H1N1 du virus de la grippe A › Discovery of Novel Boron-Containing
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN de polarité négative › Orthomyxoviridae › Influenzavirus A › Virus de la grippe A › Sous-type H5N1 du virus de la grippe A › Discovery of Novel Boron-Containing
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN de polarité négative › Orthomyxoviridae › Influenzavirus A › Virus de la grippe A › Discovery of Novel Boron-Containing
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Discovery of Novel Boron-Containing
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Discovery of Novel Boron-Containing
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Glycosidases › Sialidase › Discovery of Novel Boron-Containing
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures alicycliques › Cyclohexanes › Cyclohexènes › Oséltamivir › Discovery of Novel Boron-Containing