Arianna Loregian

Affiliations

Department of Molecular Medicine, University of Padua, 35121 Padua, Italy.

Publications (31)

The Dimeric Form of HPV16 E6 Is Crucial to Drive YAP/TAZ Upregulation through the Targeting of hScrib.

Cancers

Avec: Lorenzo Messa , Marta Celegato , Chiara Bertagnin , Beatrice Mercorelli , Gualtiero Alvisi , Lawrence Banks , Giorgio Palù , Arianna Loregian

Small-Molecule Inhibitor of Flaviviral NS3-NS5 Interaction with Broad-Spectrum Activity and Efficacy

mBio

Avec: Marta Celegato , Mattia Sturlese , Vivian Vasconcelos Costa , Marta Trevisan , Angélica Samer Lallo Dias , Ingredy Beatriz Souza Passos , Celso Martins Queiroz-Junior , Lorenzo Messa , Annagiulia Favaro , Stefano Moro , Mauro Martins Teixeira , Arianna Loregian , Beatrice Mercorelli

A novel

Journal of enzyme inhibition and medicinal chemistry

Avec: Jiwei Zhang , Chuanfeng Liu , Ruifang Jia , Xujie Zhang , Jian Zhang , Chiara Bertagnin , Anna Bonomini , Laura Guizzo , Yuanmin Jiang , Huinan Jia , Shuzhen Jia , Xiuli Ma , Arianna Loregian , Bing Huang , Peng Zhan , Xinyong Liu

Synthesis and characterization of 1,2,4-triazolo[1,5-a]pyrimidine-2-carboxamide-based compounds targeting the PA-PB1 interface of influenza A virus polymerase.

European journal of medicinal chemistry

Avec: Serena Massari , Chiara Bertagnin , Maria Chiara Pismataro , Anna Donnadio , Giulio Nannetti , Tommaso Felicetti , Stefano Di Bona , Maria Giulia Nizi , Leonardo Tensi , Giuseppe Manfroni , Maria Isabel Loza , Stefano Sabatini , Violetta Cecchetti , Jose Brea , Laura Goracci , Arianna Loregian , Oriana Tabarrini

Design, Synthesis, and Biological Evaluation of Trisubstituted Piperazine Derivatives as Noncovalent Severe Acute Respiratory Syndrome Coronavirus 2 Main Protease Inhibitors with Improved Antiviral Activity and Favorable Druggability.

Journal of medicinal chemistry

Avec: Shenghua Gao , Letian Song , Katharina Sylvester , Beatrice Mercorelli , Arianna Loregian , Karoly Toth , Renato H Weiße , Abibe Useini , Norbert Sträter , Mianling Yang , Bing Ye , Ann E Tollefson , Christa E Müller , Xinyong Liu , Peng Zhan

Discovery of N-substituted oseltamivir derivatives as novel neuraminidase inhibitors with improved drug resistance profiles and favorable drug-like properties.

European journal of medicinal chemistry

Avec: Ruifang Jia , Jiwei Zhang , Fangyuan Shi , Anna Bonomini , Camilla Lucca , Chiara Bertagnin , Jian Zhang , Chuanfeng Liu , Huinan Jia , Yuanmin Jiang , Xiuli Ma , Arianna Loregian , Bing Huang , Peng Zhan , Xinyong Liu

Design, synthesis, and biological evaluation of first-in-class indomethacin-based PROTACs degrading SARS-CoV-2 main protease and with broad-spectrum antiviral activity.

European journal of medicinal chemistry

Avec: Jenny Desantis , Alessandro Bazzacco , Michela Eleuteri , Sara Tuci , Elisa Bianconi , Antonio Macchiarulo , Beatrice Mercorelli , Arianna Loregian , Laura Goracci

Suppression of a SARS-CoV-2 outbreak in the Italian municipality of Vo'.

Nature

Avec: Enrico Lavezzo , Elisa Franchin , Constanze Ciavarella , Gina Cuomo-Dannenburg , Luisa Barzon , Claudia Del Vecchio , Lucia Rossi , Riccardo Manganelli , Arianna Loregian , Nicolò Navarin , Davide Abate , Manuela Sciro , Stefano Merigliano , Ettore De Canale , Maria Cristina Vanuzzo , Valeria Besutti , Francesca Saluzzo , Francesco Onelia , Monia Pacenti , Saverio G Parisi , Giovanni Carretta , Daniele Donato , Luciano Flor , Silvia Cocchio , Giulia Masi , Alessandro Sperduti , Lorenzo Cattarino , Renato Salvador , Michele Nicoletti , Federico Caldart , Gioele Castelli , Eleonora Nieddu , Beatrice Labella , Ludovico Fava , Matteo Drigo , Katy A M Gaythorpe , Auteur inconnu , Alessandra R Brazzale , Stefano Toppo , Marta Trevisan , Vincenzo Baldo , Christl A Donnelly , Neil M Ferguson , Ilaria Dorigatti , Andrea Crisanti , Auteur inconnu

Potent and broad-spectrum cycloheptathiophene-3-carboxamide compounds that target the PA-PB1 interaction of influenza virus RNA polymerase and possess a high barrier to drug resistance.

Antiviral research

Avec: Giulio Nannetti , Serena Massari , Beatrice Mercorelli , Chiara Bertagnin , Jenny Desantis , Giorgio Palù , Oriana Tabarrini , Arianna Loregian

1,2,4-Triazolo[1,5-a]pyrimidines: Efficient one-step synthesis and functionalization as influenza polymerase PA-PB1 interaction disruptors.

European journal of medicinal chemistry

Avec: Maria Chiara Pismataro , Tommaso Felicetti , Chiara Bertagnin , Maria Giulia Nizi , Anna Bonomini , Maria Letizia Barreca , Violetta Cecchetti , Dirk Jochmans , Steven De Jonghe , Johan Neyts , Arianna Loregian , Oriana Tabarrini , Serena Massari

Contemporary medicinal chemistry strategies for the discovery and optimization of influenza inhibitors targeting vRNP constituent proteins.

Acta pharmaceutica Sinica. B

Avec: Lingxin Hou , Ying Zhang , Han Ju , Srinivasulu Cherukupalli , Ruifang Jia , Jian Zhang , Bing Huang , Arianna Loregian , Xinyong Liu , Peng Zhan

Optimization of potent, broad-spectrum, and specific anti-influenza compounds targeting RNA polymerase PA-PB1 heterodimerization.

European journal of medicinal chemistry

Avec: Anna Bonomini , Tommaso Felicetti , Martina Pacetti , Chiara Bertagnin , Alice Coletti , Federica Giammarino , Marta De Angelis , Federica Poggialini , Antonio Macchiarulo , Stefano Sabatini , Beatrice Mercorelli , Lucia Nencioni , Ilaria Vicenti , Elena Dreassi , Violetta Cecchetti , Oriana Tabarrini , Arianna Loregian , Serena Massari

Exploring a New Generation of Pyrimidine and Pyridine Derivatives as Anti-Influenza Agents Targeting the Polymerase PA-PB1 Subunits Interaction.

Pharmaceutics

Avec: Ilaria Giacchello , Annarita Cianciusi , Chiara Bertagnin , Anna Bonomini , Valeria Francesconi , Mattia Mori , Anna Carbone , Francesca Musumeci , Arianna Loregian , Silvia Schenone

A novel small-molecule inhibitor of the human papillomavirus E6-p53 interaction that reactivates p53 function and blocks cancer cells growth.

Cancer letters

Avec: Marta Celegato , Lorenzo Messa , Laura Goracci , Beatrice Mercorelli , Chiara Bertagnin , Francesca Spyrakis , Irina Suarez , Alexandra Cousido-Siah , Gilles Travé , Lawrence Banks , Gabriele Cruciani , Giorgio Palù , Arianna Loregian

The isoquinoline alkaloid berberine inhibits human cytomegalovirus replication by interfering with the viral Immediate Early-2 (IE2) protein transactivating activity.

Antiviral research

Avec: Anna Luganini , Beatrice Mercorelli , Lorenzo Messa , Giorgio Palù , Giorgio Gribaudo , Arianna Loregian

HPV-induced cancers: preclinical therapeutic advancements.

Expert opinion on investigational drugs

Avec: Lorenzo Messa , Arianna Loregian

The antifungal drug isavuconazole inhibits the replication of human cytomegalovirus (HCMV) and acts synergistically with anti-HCMV drugs.

Antiviral research

Avec: Beatrice Mercorelli , Marta Celegato , Anna Luganini , Giorgio Gribaudo , Galina I Lepesheva , Arianna Loregian

Discovery of highly potent and selective influenza virus neuraminidase inhibitors targeting 150-cavity.

European journal of medicinal chemistry

Avec: Ruifang Jia , Jian Zhang , Chiara Bertagnin , Srinivasulu Cherukupalli , Wei Ai , Xiao Ding , Zhuo Li , Jiwei Zhang , Han Ju , Xiuli Ma , Arianna Loregian , Bing Huang , Peng Zhan , Xinyong Liu

Human neural progenitor cell models to study the antiviral effects and neuroprotective potential of approved and investigational human cytomegalovirus inhibitors.

Antiviral research

Avec: Marta Trevisan , Anna Pianezzola , Marco Onorati , Lorenzo Apolloni , Mauro Pistello , Ravit Arav-Boger , Giorgio Palù , Beatrice Mercorelli , Arianna Loregian

Switching the three-component Biginelli-like reaction conditions for the regioselective synthesis of new 2-amino[1,2,4]triazolo[1,5-

Organic & biomolecular chemistry

Avec: Martina Pacetti , Maria Chiara Pismataro , Tommaso Felicetti , Federica Giammarino , Anna Bonomini , Matteo Tiecco , Chiara Bertagnin , Maria Letizia Barreca , Raimondo Germani , Violetta Cecchetti , Ilaria Vicenti , Oriana Tabarrini , Maurizio Zazzi , Arianna Loregian , Serena Massari

Synergistic activity of an RNA polymerase PA-PB1 interaction inhibitor with oseltamivir against human and avian influenza viruses in cell culture and in ovo.

Antiviral research

Avec: Anna Bonomini , Jiwei Zhang , Han Ju , Alessia Zago , Martina Pacetti , Oriana Tabarrini , Serena Massari , Xinyong Liu , Beatrice Mercorelli , Peng Zhan , Arianna Loregian

Drug Repurposing Campaigns for Human Cytomegalovirus Identify a Natural Compound Targeting the Immediate-Early 2 (IE2) Protein: A Comment on "The Natural Flavonoid Compound Deguelin Inhibits HCMV Lytic Replication within Fibroblasts".

Viruses

Avec: Beatrice Mercorelli , Anna Luganini , Giorgio Palù , Giorgio Gribaudo , Arianna Loregian

The Clinically Approved Antifungal Drug Posaconazole Inhibits Human Cytomegalovirus Replication.

Antimicrobial agents and chemotherapy

Avec: Beatrice Mercorelli , Anna Luganini , Marta Celegato , Giorgio Palù , Giorgio Gribaudo , Galina I Lepesheva , Arianna Loregian

Indomethacin-based PROTACs as pan-coronavirus antiviral agents.

European journal of medicinal chemistry

Avec: Jenny Desantis , Beatrice Mercorelli , Marta Celegato , Federico Croci , Alessandro Bazzacco , Massimo Baroni , Lydia Siragusa , Gabriele Cruciani , Arianna Loregian , Laura Goracci

Identification of C5-NH

Journal of medicinal chemistry

Avec: Han Ju , N Arul Murugan , Lingxin Hou , Ping Li , Laura Guizzo , Ying Zhang , Chiara Bertagnin , Xiujie Kong , Dongwei Kang , Ruifang Jia , Xiuli Ma , Ruikun Du , Vasanthanathan Poongavanam , Arianna Loregian , Bing Huang , Xinyong Liu , Peng Zhan

Viruses

Avec: Hanieh Ghassabian , Federico Falchi , Martina Timmoneri , Beatrice Mercorelli , Arianna Loregian , Giorgio Palù , Gualtiero Alvisi

Targeted Disruption of E6/p53 Binding Exerts Broad Activity and Synergism with Paclitaxel and Topotecan against HPV-Transformed Cancer Cells.

Cancers

Avec: Marta Celegato , Lorenzo Messa , Chiara Bertagnin , Beatrice Mercorelli , Arianna Loregian

Discovery of Novel Boron-Containing

Molecules (Basel, Switzerland)

Avec: Ruifang Jia , Jiwei Zhang , Jian Zhang , Chiara Bertagnin , Anna Bonomini , Laura Guizzo , Zhen Gao , Xiangkai Ji , Zhuo Li , Chuanfeng Liu , Han Ju , Xiuli Ma , Arianna Loregian , Bing Huang , Peng Zhan , Xinyong Liu

Iterative Optimization and Structure-Activity Relationship Studies of Oseltamivir Amino Derivatives as Potent and Selective Neuraminidase Inhibitors

Journal of medicinal chemistry

Avec: Han Ju , Lingxin Hou , Fabao Zhao , Ying Zhang , Ruifang Jia , Laura Guizzo , Anna Bonomini , Jiwei Zhang , Zhen Gao , Ruipeng Liang , Chiara Bertagnin , Xiujie Kong , Xiuli Ma , Dongwei Kang , Arianna Loregian , Bing Huang , Xinyong Liu , Peng Zhan

Discovery of novel SARS-CoV-2 inhibitors targeting the main protease M

Antiviral research

Avec: Beatrice Mercorelli , Jenny Desantis , Marta Celegato , Alessandro Bazzacco , Lydia Siragusa , Paolo Benedetti , Michela Eleuteri , Federico Croci , Gabriele Cruciani , Laura Goracci , Arianna Loregian

A small molecule targeting the interaction between human papillomavirus E7 oncoprotein and cellular phosphatase PTPN14 exerts antitumoral activity in cervical cancer cells.

Cancer letters

Avec: Chiara Bertagnin , Lorenzo Messa , Matteo Pavan , Marta Celegato , Mattia Sturlese , Beatrice Mercorelli , Stefano Moro , Arianna Loregian

Réseau de co-auteurs

Beatrice Mercorelli 18 collaborations

Chiara Bertagnin 16 collaborations

Marta Celegato 9 collaborations

Anna Bonomini 9 collaborations

Peng Zhan 9 collaborations

Xinyong Liu 9 collaborations

Giorgio Palù 8 collaborations

Lorenzo Messa 7 collaborations

Ruifang Jia 7 collaborations

Bing Huang 7 collaborations

Jiwei Zhang 6 collaborations

Xiuli Ma 6 collaborations

Serena Massari 6 collaborations

Oriana Tabarrini 6 collaborations

Han Ju 6 collaborations

Jian Zhang 5 collaborations

Laura Goracci 5 collaborations

Laura Guizzo 4 collaborations

Tommaso Felicetti 4 collaborations

Violetta Cecchetti 4 collaborations

Jenny Desantis 4 collaborations

Anna Luganini 4 collaborations

Giorgio Gribaudo 4 collaborations

Marta Trevisan 3 collaborations

Chuanfeng Liu 3 collaborations

Maria Chiara Pismataro 3 collaborations

Alessandro Bazzacco 3 collaborations

Lingxin Hou 3 collaborations

Ying Zhang 3 collaborations

Martina Pacetti 3 collaborations

Gabriele Cruciani 3 collaborations

Gualtiero Alvisi 2 collaborations

Lawrence Banks 2 collaborations

Mattia Sturlese 2 collaborations

Stefano Moro 2 collaborations

Yuanmin Jiang 2 collaborations

Huinan Jia 2 collaborations

Giulio Nannetti 2 collaborations

Maria Giulia Nizi 2 collaborations

Stefano Sabatini 2 collaborations

Michela Eleuteri 2 collaborations

Antonio Macchiarulo 2 collaborations

None None 2 collaborations

Maria Letizia Barreca 2 collaborations

Srinivasulu Cherukupalli 2 collaborations

Federica Giammarino 2 collaborations

Ilaria Vicenti 2 collaborations

Galina I Lepesheva 2 collaborations

Zhuo Li 2 collaborations

Federico Croci 2 collaborations

Lydia Siragusa 2 collaborations

Xiujie Kong 2 collaborations

Dongwei Kang 2 collaborations

Zhen Gao 2 collaborations

Vivian Vasconcelos Costa 1 collaboration

Angélica Samer Lallo Dias 1 collaboration

Ingredy Beatriz Souza Passos 1 collaboration

Celso Martins Queiroz-Junior 1 collaboration

Annagiulia Favaro 1 collaboration

Mauro Martins Teixeira 1 collaboration

Xujie Zhang 1 collaboration

Shuzhen Jia 1 collaboration

Anna Donnadio 1 collaboration

Stefano Di Bona 1 collaboration

Leonardo Tensi 1 collaboration

Giuseppe Manfroni 1 collaboration

Maria Isabel Loza 1 collaboration

Jose Brea 1 collaboration

Shenghua Gao 1 collaboration

Letian Song 1 collaboration

Katharina Sylvester 1 collaboration

Karoly Toth 1 collaboration

Renato H Weiße 1 collaboration

Abibe Useini 1 collaboration

Norbert Sträter 1 collaboration

Mianling Yang 1 collaboration

Bing Ye 1 collaboration

Ann E Tollefson 1 collaboration

Christa E Müller 1 collaboration

Fangyuan Shi 1 collaboration

Camilla Lucca 1 collaboration

Sara Tuci 1 collaboration

Elisa Bianconi 1 collaboration

Enrico Lavezzo 1 collaboration

Elisa Franchin 1 collaboration

Constanze Ciavarella 1 collaboration

Gina Cuomo-Dannenburg 1 collaboration

Luisa Barzon 1 collaboration

Claudia Del Vecchio 1 collaboration

Lucia Rossi 1 collaboration

Riccardo Manganelli 1 collaboration

Nicolò Navarin 1 collaboration

Davide Abate 1 collaboration

Manuela Sciro 1 collaboration

Stefano Merigliano 1 collaboration

Ettore De Canale 1 collaboration

Maria Cristina Vanuzzo 1 collaboration

Valeria Besutti 1 collaboration

Francesca Saluzzo 1 collaboration

Francesco Onelia 1 collaboration

Monia Pacenti 1 collaboration

Saverio G Parisi 1 collaboration

Giovanni Carretta 1 collaboration

Daniele Donato 1 collaboration

Luciano Flor 1 collaboration

Silvia Cocchio 1 collaboration

Giulia Masi 1 collaboration

Alessandro Sperduti 1 collaboration

Lorenzo Cattarino 1 collaboration

Renato Salvador 1 collaboration

Michele Nicoletti 1 collaboration

Federico Caldart 1 collaboration

Gioele Castelli 1 collaboration

Eleonora Nieddu 1 collaboration

Beatrice Labella 1 collaboration

Ludovico Fava 1 collaboration

Matteo Drigo 1 collaboration

Katy A M Gaythorpe 1 collaboration

Alessandra R Brazzale 1 collaboration

Stefano Toppo 1 collaboration

Vincenzo Baldo 1 collaboration

Christl A Donnelly 1 collaboration

Neil M Ferguson 1 collaboration

Ilaria Dorigatti 1 collaboration

Andrea Crisanti 1 collaboration

Dirk Jochmans 1 collaboration

Steven De Jonghe 1 collaboration

Johan Neyts 1 collaboration

Alice Coletti 1 collaboration

Marta De Angelis 1 collaboration

Federica Poggialini 1 collaboration

Lucia Nencioni 1 collaboration

Elena Dreassi 1 collaboration

Ilaria Giacchello 1 collaboration

Annarita Cianciusi 1 collaboration

Valeria Francesconi 1 collaboration

Mattia Mori 1 collaboration

Anna Carbone 1 collaboration

Francesca Musumeci 1 collaboration

Silvia Schenone 1 collaboration

Francesca Spyrakis 1 collaboration

Irina Suarez 1 collaboration

Alexandra Cousido-Siah 1 collaboration

Gilles Travé 1 collaboration

Wei Ai 1 collaboration

Xiao Ding 1 collaboration

Anna Pianezzola 1 collaboration

Marco Onorati 1 collaboration

Lorenzo Apolloni 1 collaboration

Mauro Pistello 1 collaboration

Ravit Arav-Boger 1 collaboration

Matteo Tiecco 1 collaboration

Raimondo Germani 1 collaboration

Maurizio Zazzi 1 collaboration

Alessia Zago 1 collaboration

Massimo Baroni 1 collaboration

N Arul Murugan 1 collaboration

Ping Li 1 collaboration

Ruikun Du 1 collaboration

Vasanthanathan Poongavanam 1 collaboration

Hanieh Ghassabian 1 collaboration

Federico Falchi 1 collaboration

Martina Timmoneri 1 collaboration

Xiangkai Ji 1 collaboration

Fabao Zhao 1 collaboration

Ruipeng Liang 1 collaboration

Paolo Benedetti 1 collaboration

Matteo Pavan 1 collaboration