Small-Molecule Inhibitor of Flaviviral NS3-NS5 Interaction with Broad-Spectrum Activity and Efficacy
NS3-NS5 interaction
West-Nile virus
Zika virus
antiviral agents
antiviral drugs
dengue virus
dissociative inhibitors
flavivirus
Journal
mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231
Informations de publication
Date de publication:
28 02 2023
28 02 2023
Historique:
pubmed:
10
1
2023
medline:
3
3
2023
entrez:
9
1
2023
Statut:
ppublish
Résumé
Every year, dengue virus (DENV) causes one hundred million infections worldwide that can result in dengue disease and severe dengue. Two other mosquito-borne flaviviruses, i.e., Zika virus (ZIKV) and West Nile virus (WNV), are responsible of prolonged outbreaks and are associated with severe neurological diseases, congenital defects, and eventually death. These three viruses, despite their importance for global public health, still lack specific drug treatments. Here, we describe the structure-guided discovery of small molecules with pan-flavivirus antiviral potential by a virtual screening of ~1 million structures targeting the NS3-NS5 interaction surface of different flaviviruses. Two molecules inhibited the interaction between DENV NS3 and NS5
Identifiants
pubmed: 36622141
doi: 10.1128/mbio.03097-22
pmc: PMC9973282
doi:
Substances chimiques
Antiviral Agents
0
Viral Nonstructural Proteins
0
NS3 protein, flavivirus
0
NS5 protein, flavivirus
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0309722Références
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