Norbert Sträter

Affiliations

Center for Biotechnology and Biomedicine, Leipzig University, Deutscher Platz 5, 04103 Leipzig, Germany.

ORCID: 0000-0002-2001-0500

Publications (30)

Structure-Activity Relationship of 3-Methylcytidine-5'-α,β-methylenediphosphates as CD73 Inhibitors.

Journal of medicinal chemistry

Avec: Mirko Scortichini , Riham Mohammed Idris , Susanne Moschütz , Antje Keim , Veronica Salmaso , Clemens Dobelmann , Paola Oliva , Karolina Losenkova , Heikki Irjala , Samuli Vaittinen , Jouko Sandholm , Gennady G Yegutkin , Norbert Sträter , Anna Junker , Christa E Müller , Kenneth A Jacobson

Development of an active-site titrant for SARS-CoV-2 main protease as an indispensable tool for evaluating enzyme kinetics.

Acta pharmaceutica Sinica. B

Avec: Rabea Voget , Julian Breidenbach , Tobias Claff , Alexandra Hingst , Katharina Sylvester , Christian Steinebach , Lan Phuong Vu , Renato H Weiße , Ulrike Bartz , Norbert Sträter , Christa E Müller , Michael Gütschow

Ribosomal Target-Binding Sites of Antimicrobial Peptides Api137 and Onc112 Are Conserved among Pathogens Indicating New Lead Structures To Develop Novel Broad-Spectrum Antibiotics.

Chembiochem : a European journal of chemical biology

Avec: Lisa Kolano , Daniel Knappe , Daniela Volke , Norbert Sträter , Ralf Hoffmann

Substrate binding modes of purine and pyrimidine nucleotides to human ecto-5'-nucleotidase (CD73) and inhibition by their bisphosphonic acid derivatives.

Purinergic signalling

Avec: Emma Scaletti , Franziska U Huschmann , Uwe Mueller , Manfred S Weiss , Norbert Sträter

Discovery and Crystallographic Studies of Nonpeptidic Piperazine Derivatives as Covalent SARS-CoV-2 Main Protease Inhibitors.

Journal of medicinal chemistry

Avec: Shenghua Gao , Letian Song , Tobias Claff , Molly Woodson , Katharina Sylvester , Lanlan Jing , Renato H Weiße , Yusen Cheng , Norbert Sträter , Laura Schäkel , Michael Gütschow , Bing Ye , Mianling Yang , Tao Zhang , Dongwei Kang , Karoly Toth , John Tavis , Ann E Tollefson , Christa E Müller , Peng Zhan , Xinyong Liu

PTK7 is a positive allosteric modulator of GPR133 signaling in glioblastoma.

Cell reports

Avec: Joshua D Frenster , Hediye Erdjument-Bromage , Gabriele Stephan , Niklas Ravn-Boess , Shuai Wang , Wenke Liu , Devin Bready , Jordan Wilcox , Björn Kieslich , Manuel Jankovic , Caroline Wilde , Susanne Horn , Norbert Sträter , Ines Liebscher , Torsten Schöneberg , David Fenyo , Thomas A Neubert , Dimitris G Placantonakis

Discovery of Potent and Selective Methylenephosphonic Acid CD73 Inhibitors.

Journal of medicinal chemistry

Avec: Ehesan U Sharif , Jaroslaw Kalisiak , Kenneth V Lawson , Dillon H Miles , Eric Newcomb , Erick A Lindsey , Brandon R Rosen , Laurent P P Debien , Ada Chen , Xiaoning Zhao , Stephen W Young , Nigel P Walker , Norbert Sträter , Emma R Scaletti , Lixia Jin , Guifen Xu , Manmohan R Leleti , Jay P Powers

Discovery of AB680: A Potent and Selective Inhibitor of CD73.

Journal of medicinal chemistry

Avec: Kenneth V Lawson , Jaroslaw Kalisiak , Erick A Lindsey , Eric T Newcomb , Manmohan Reddy Leleti , Laurent Debien , Brandon R Rosen , Dillon H Miles , Ehesan U Sharif , Jenna L Jeffrey , Joanne B L Tan , Ada Chen , Sharon Zhao , Guifen Xu , Lijuan Fu , Lixia Jin , Tim W Park , Wade Berry , Susanne Moschütz , Emma Scaletti , Norbert Sträter , Nigel P Walker , Stephen W Young , Matthew J Walters , Uli Schindler , Jay P Powers

Low Carbon Footprint Recycling of Post-Consumer PET Plastic with a Metagenomic Polyester Hydrolase.

ChemSusChem

Avec: Christian Sonnendecker , Juliane Oeser , P Konstantin Richter , Patrick Hille , Ziyue Zhao , Cornelius Fischer , Holger Lippold , Paula Blázquez-Sánchez , Felipe Engelberger , César A Ramírez-Sarmiento , Thorsten Oeser , Yuliia Lihanova , Ronny Frank , Heinz-Georg Jahnke , Susan Billig , Bernd Abel , Norbert Sträter , Jörg Matysik , Wolfgang Zimmermann

Mono-ADP-ribosylation sites of human CD73 inhibit its adenosine-generating enzymatic activity.

Purinergic signalling

Avec: Julia Hesse , Mona K Rosse , Bodo Steckel , Bernhard Blank-Landeshammer , Svenja Idel , Yvonne Reinders , Albert Sickmann , Norbert Sträter , Jürgen Schrader

Macrocyclic Azapeptide Nitriles: Structure-Based Discovery of Potent SARS-CoV-2 Main Protease Inhibitors as Antiviral Drugs.

Journal of medicinal chemistry

Avec: Julian Breidenbach , Rabea Voget , Yaoyao Si , Alexandra Hingst , Tobias Claff , Katharina Sylvester , Valentina Wolf , Vesa Krasniqi , Abibe Useini , Norbert Sträter , Yukino Ogura , Atsushi Kawaguchi , Christa E Müller , Michael Gütschow

Crystal structure of adenosine A

Communications chemistry

Avec: Tobias Claff , Jonathan G Schlegel , Jan H Voss , Victoria J Vaaßen , Renato H Weiße , Robert K Y Cheng , Sandra Markovic-Mueller , Denis Bucher , Norbert Sträter , Christa E Müller

The dimerized pentraxin-like domain of the adhesion G protein-coupled receptor 112 (ADGRG4) suggests function in sensing mechanical forces.

The Journal of biological chemistry

Avec: Björn Kieslich , Renato H Weiße , Jana Brendler , Albert Ricken , Torsten Schöneberg , Norbert Sträter

Membrane Phospholipids and Polyphosphates as Cofactors and Binding Molecules of SERPINA12 (vaspin).

Molecules (Basel, Switzerland)

Avec: Catherine A Tindall , Sebastian Dommel , Veronika Riedl , David Ulbricht , Stefanie Hanke , Norbert Sträter , John T Heiker

Structural Studies on the Inhibitory Binding Mode of Aromatic Coumarinic Esters to Human Kallikrein-Related Peptidase 7.

Journal of medicinal chemistry

Avec: Stefanie Hanke , Catherine A Tindall , Jan Pippel , David Ulbricht , Bernard Pirotte , Michèle Reboud-Ravaux , John T Heiker , Norbert Sträter

Calcium-sensing receptor-mediated NLRP3 inflammasome response to calciprotein particles drives inflammation in rheumatoid arthritis.

Nature communications

Avec: Elisabeth Jäger , Supriya Murthy , Caroline Schmidt , Magdalena Hahn , Sarah Strobel , Anna Peters , Claudia Stäubert , Pelin Sungur , Tom Venus , Mandy Geisler , Veselina Radusheva , Stefanie Raps , Kathrin Rothe , Roger Scholz , Sebastian Jung , Sylke Wagner , Matthias Pierer , Olga Seifert , Wenhan Chang , Irina Estrela-Lopis , Nora Raulien , Knut Krohn , Norbert Sträter , Stephanie Hoeppener , Torsten Schöneberg , Manuela Rossol , Ulf Wagner

2-Substituted α,β-Methylene-ADP Derivatives: Potent Competitive Ecto-5'-nucleotidase (CD73) Inhibitors with Variable Binding Modes.

Journal of medicinal chemistry

Avec: Sanjay Bhattarai , Jan Pippel , Emma Scaletti , Riham Idris , Marianne Freundlieb , Georg Rolshoven , Christian Renn , Sang-Yong Lee , Aliaa Abdelrahman , Herbert Zimmermann , Ali El-Tayeb , Christa E Müller , Norbert Sträter

Structures of 2-Hydroxyisobutyric Acid-CoA Ligase Reveal Determinants of Substrate Specificity and Describe a Multi-Conformational Catalytic Cycle.

Journal of molecular biology

Avec: Michael Zahn , Nadya Kurteva-Yaneva , Judith Schuster , Ulrike Krug , Tina Georgi , Roland H Müller , Thore Rohwerder , Norbert Sträter

Functional impact of intramolecular cleavage and dissociation of adhesion G protein-coupled receptor GPR133 (ADGRD1) on canonical signaling.

The Journal of biological chemistry

Avec: Joshua D Frenster , Gabriele Stephan , Niklas Ravn-Boess , Devin Bready , Jordan Wilcox , Bjoern Kieslich , Caroline Wilde , Norbert Sträter , Giselle R Wiggin , Ines Liebscher , Torsten Schöneberg , Dimitris G Placantonakis

Analysis of double-emulsion droplets with ESI mass spectrometry for monitoring lipase-catalyzed ester hydrolysis at nanoliter scale.

Analytical and bioanalytical chemistry

Avec: Laura Heiligenthal , Marie van der Loh , Matthias Polack , Maximilian E Blaha , Susanne Moschütz , Antje Keim , Norbert Sträter , Detlev Belder

Design, Synthesis, and Biological Evaluation of Trisubstituted Piperazine Derivatives as Noncovalent Severe Acute Respiratory Syndrome Coronavirus 2 Main Protease Inhibitors with Improved Antiviral Activity and Favorable Druggability.

Journal of medicinal chemistry

Avec: Shenghua Gao , Letian Song , Katharina Sylvester , Beatrice Mercorelli , Arianna Loregian , Karoly Toth , Renato H Weiße , Abibe Useini , Norbert Sträter , Mianling Yang , Bing Ye , Ann E Tollefson , Christa E Müller , Xinyong Liu , Peng Zhan

Structure and function of the metagenomic plastic-degrading polyester hydrolase PHL7 bound to its product.

Nature communications

Avec: P Konstantin Richter , Paula Blázquez-Sánchez , Ziyue Zhao , Felipe Engelberger , Christian Wiebeler , Georg Künze , Ronny Frank , Dana Krinke , Emanuele Frezzotti , Yuliia Lihanova , Patricia Falkenstein , Jörg Matysik , Wolfgang Zimmermann , Norbert Sträter , Christian Sonnendecker

Discovery of Potent and Selective Non-Nucleotide Small Molecule Inhibitors of CD73.

Journal of medicinal chemistry

Avec: Joel W Beatty , Erick A Lindsey , Rhiannon Thomas-Tran , Laurent Debien , Debashis Mandal , Jenna L Jeffrey , Anh T Tran , Jeremy Fournier , Steven D Jacob , Xuelei Yan , Samuel L Drew , Elaine Ginn , Ada Chen , Amber T Pham , Sharon Zhao , Lixia Jin , Stephen W Young , Nigel P Walker , Manmohan Reddy Leleti , Susanne Moschütz , Norbert Sträter , Jay P Powers , Kenneth V Lawson

Structural and Mechanistic Studies on Substrate and Stereoselectivity of the Indole Monooxygenase VpIndA1: New Avenues for Biocatalytic Epoxidations and Sulfoxidations.

Angewandte Chemie (International ed. in English)

Avec: Julia Kratky , Daniel Eggerichs , Thomas Heine , Sarah Hofmann , Philipp Sowa , Renato H Weiße , Dirk Tischler , Norbert Sträter

Discovery and Crystallographic Studies of Trisubstituted Piperazine Derivatives as Non-Covalent SARS-CoV-2 Main Protease Inhibitors with High Target Specificity and Low Toxicity.

Journal of medicinal chemistry

Avec: Shenghua Gao , Katharina Sylvester , Letian Song , Tobias Claff , Lanlan Jing , Molly Woodson , Renato H Weiße , Yusen Cheng , Laura Schäkel , Marvin Petry , Michael Gütschow , Anke C Schiedel , Norbert Sträter , Dongwei Kang , Shujing Xu , Karoly Toth , John Tavis , Ann E Tollefson , Christa E Müller , Xinyong Liu , Peng Zhan

Structural basis of the activation of PPARγ by the plasticizer metabolites MEHP and MINCH.

Environment international

Avec: Abibe Useini , Felipe Engelberger , Georg Künze , Norbert Sträter

Structural Insights into Partial Activation of the Prototypic G Protein-Coupled Adenosine A

ACS pharmacology & translational science

Avec: Tobias Claff , Andhika B Mahardhika , Victoria J Vaaßen , Jonathan G Schlegel , Christin Vielmuth , Renato H Weiße , Norbert Sträter , Christa E Müller

Structural Studies on the Binding Mode of Bisphenols to PPARγ.

Biomolecules

Avec: Abibe Useini , Inken Kaja Schwerin , Georg Künze , Norbert Sträter

Nonpeptidic Irreversible Inhibitors of SARS-CoV-2 Main Protease with Potent Antiviral Activity.

Journal of medicinal chemistry

Avec: Angelo Oneto , Ghazl Al Hamwi , Laura Schäkel , Nadine Krüger , Katharina Sylvester , Marvin Petry , Rasha Abu Shamleh , Thanigaimalai Pillaiyar , Tobias Claff , Anke C Schiedel , Norbert Sträter , Michael Gütschow , Christa E Müller

Miniaturized Modular Click Chemistry-enabled Rapid Discovery of Unique SARS-CoV-2 M

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Avec: Mianling Yang , Myoung Kyu Lee , Shenghua Gao , Letian Song , Hye-Yeon Jang , Inseong Jo , Chun-Chiao Yang , Katharina Sylvester , Chunkyu Ko , Shuo Wang , Bing Ye , Kai Tang , Junyi Li , Manyu Gu , Christa E Müller , Norbert Sträter , Xinyong Liu , Meehyein Kim , Peng Zhan

Réseau de co-auteurs

Christa E Müller 11 collaborations

Renato H Weiße 8 collaborations

Tobias Claff 7 collaborations

Katharina Sylvester 7 collaborations

Michael Gütschow 5 collaborations

Susanne Moschütz 4 collaborations

Shenghua Gao 4 collaborations

Letian Song 4 collaborations

Peng Zhan 4 collaborations

Xinyong Liu 4 collaborations

Torsten Schöneberg 4 collaborations

Abibe Useini 4 collaborations

Emma Scaletti 3 collaborations

Laura Schäkel 3 collaborations

Bing Ye 3 collaborations

Mianling Yang 3 collaborations

Karoly Toth 3 collaborations

Ann E Tollefson 3 collaborations

Kenneth V Lawson 3 collaborations

Erick A Lindsey 3 collaborations

Ada Chen 3 collaborations

Stephen W Young 3 collaborations

Nigel P Walker 3 collaborations

Lixia Jin 3 collaborations

Jay P Powers 3 collaborations

Felipe Engelberger 3 collaborations

Georg Künze 3 collaborations

Antje Keim 2 collaborations

Rabea Voget 2 collaborations

Julian Breidenbach 2 collaborations

Alexandra Hingst 2 collaborations

Molly Woodson 2 collaborations

Lanlan Jing 2 collaborations

Yusen Cheng 2 collaborations

Dongwei Kang 2 collaborations

John Tavis 2 collaborations

Joshua D Frenster 2 collaborations

Gabriele Stephan 2 collaborations

Niklas Ravn-Boess 2 collaborations

Devin Bready 2 collaborations

Jordan Wilcox 2 collaborations

Björn Kieslich 2 collaborations

Caroline Wilde 2 collaborations

Ines Liebscher 2 collaborations

Dimitris G Placantonakis 2 collaborations

Ehesan U Sharif 2 collaborations

Jaroslaw Kalisiak 2 collaborations

Dillon H Miles 2 collaborations

Brandon R Rosen 2 collaborations

Guifen Xu 2 collaborations

Manmohan Reddy Leleti 2 collaborations

Laurent Debien 2 collaborations

Jenna L Jeffrey 2 collaborations

Sharon Zhao 2 collaborations

Christian Sonnendecker 2 collaborations

P Konstantin Richter 2 collaborations

Ziyue Zhao 2 collaborations

Paula Blázquez-Sánchez 2 collaborations

Yuliia Lihanova 2 collaborations

Ronny Frank 2 collaborations

Jörg Matysik 2 collaborations

Wolfgang Zimmermann 2 collaborations

Jonathan G Schlegel 2 collaborations

Victoria J Vaaßen 2 collaborations

Catherine A Tindall 2 collaborations

David Ulbricht 2 collaborations

Stefanie Hanke 2 collaborations

John T Heiker 2 collaborations

Jan Pippel 2 collaborations

Marvin Petry 2 collaborations

Anke C Schiedel 2 collaborations

Mirko Scortichini 1 collaboration

Riham Mohammed Idris 1 collaboration

Veronica Salmaso 1 collaboration

Clemens Dobelmann 1 collaboration

Paola Oliva 1 collaboration

Karolina Losenkova 1 collaboration

Heikki Irjala 1 collaboration

Samuli Vaittinen 1 collaboration

Jouko Sandholm 1 collaboration

Gennady G Yegutkin 1 collaboration

Anna Junker 1 collaboration

Kenneth A Jacobson 1 collaboration

Christian Steinebach 1 collaboration

Lan Phuong Vu 1 collaboration

Ulrike Bartz 1 collaboration

Lisa Kolano 1 collaboration

Daniel Knappe 1 collaboration

Daniela Volke 1 collaboration

Ralf Hoffmann 1 collaboration

Franziska U Huschmann 1 collaboration

Uwe Mueller 1 collaboration

Manfred S Weiss 1 collaboration

Tao Zhang 1 collaboration

Hediye Erdjument-Bromage 1 collaboration

Shuai Wang 1 collaboration

Wenke Liu 1 collaboration

Manuel Jankovic 1 collaboration

Susanne Horn 1 collaboration

David Fenyo 1 collaboration

Thomas A Neubert 1 collaboration

Eric Newcomb 1 collaboration

Laurent P P Debien 1 collaboration

Xiaoning Zhao 1 collaboration

Emma R Scaletti 1 collaboration

Manmohan R Leleti 1 collaboration

Eric T Newcomb 1 collaboration

Joanne B L Tan 1 collaboration

Lijuan Fu 1 collaboration

Tim W Park 1 collaboration

Wade Berry 1 collaboration

Matthew J Walters 1 collaboration

Uli Schindler 1 collaboration

Juliane Oeser 1 collaboration

Patrick Hille 1 collaboration

Cornelius Fischer 1 collaboration

Holger Lippold 1 collaboration

César A Ramírez-Sarmiento 1 collaboration

Thorsten Oeser 1 collaboration

Heinz-Georg Jahnke 1 collaboration

Susan Billig 1 collaboration

Bernd Abel 1 collaboration

Julia Hesse 1 collaboration

Mona K Rosse 1 collaboration

Bodo Steckel 1 collaboration

Bernhard Blank-Landeshammer 1 collaboration

Svenja Idel 1 collaboration

Yvonne Reinders 1 collaboration

Albert Sickmann 1 collaboration

Jürgen Schrader 1 collaboration

Yaoyao Si 1 collaboration

Valentina Wolf 1 collaboration

Vesa Krasniqi 1 collaboration

Yukino Ogura 1 collaboration

Atsushi Kawaguchi 1 collaboration

Jan H Voss 1 collaboration

Robert K Y Cheng 1 collaboration

Sandra Markovic-Mueller 1 collaboration

Denis Bucher 1 collaboration

Jana Brendler 1 collaboration

Albert Ricken 1 collaboration

Sebastian Dommel 1 collaboration

Veronika Riedl 1 collaboration

Bernard Pirotte 1 collaboration

Michèle Reboud-Ravaux 1 collaboration

Elisabeth Jäger 1 collaboration

Supriya Murthy 1 collaboration

Caroline Schmidt 1 collaboration

Magdalena Hahn 1 collaboration

Sarah Strobel 1 collaboration

Anna Peters 1 collaboration

Claudia Stäubert 1 collaboration

Pelin Sungur 1 collaboration

Tom Venus 1 collaboration

Mandy Geisler 1 collaboration

Veselina Radusheva 1 collaboration

Stefanie Raps 1 collaboration

Kathrin Rothe 1 collaboration

Roger Scholz 1 collaboration

Sebastian Jung 1 collaboration

Sylke Wagner 1 collaboration

Matthias Pierer 1 collaboration

Olga Seifert 1 collaboration

Wenhan Chang 1 collaboration

Irina Estrela-Lopis 1 collaboration

Nora Raulien 1 collaboration

Knut Krohn 1 collaboration

Stephanie Hoeppener 1 collaboration

Manuela Rossol 1 collaboration

Ulf Wagner 1 collaboration

Sanjay Bhattarai 1 collaboration

Riham Idris 1 collaboration

Marianne Freundlieb 1 collaboration

Georg Rolshoven 1 collaboration

Christian Renn 1 collaboration

Sang-Yong Lee 1 collaboration

Aliaa Abdelrahman 1 collaboration

Herbert Zimmermann 1 collaboration

Ali El-Tayeb 1 collaboration

Michael Zahn 1 collaboration

Nadya Kurteva-Yaneva 1 collaboration

Judith Schuster 1 collaboration

Ulrike Krug 1 collaboration

Tina Georgi 1 collaboration

Roland H Müller 1 collaboration

Thore Rohwerder 1 collaboration

Bjoern Kieslich 1 collaboration

Giselle R Wiggin 1 collaboration

Laura Heiligenthal 1 collaboration

Marie van der Loh 1 collaboration

Matthias Polack 1 collaboration

Maximilian E Blaha 1 collaboration

Detlev Belder 1 collaboration

Beatrice Mercorelli 1 collaboration

Arianna Loregian 1 collaboration

Christian Wiebeler 1 collaboration

Dana Krinke 1 collaboration

Emanuele Frezzotti 1 collaboration

Patricia Falkenstein 1 collaboration

Joel W Beatty 1 collaboration

Rhiannon Thomas-Tran 1 collaboration

Debashis Mandal 1 collaboration

Anh T Tran 1 collaboration

Jeremy Fournier 1 collaboration

Steven D Jacob 1 collaboration

Xuelei Yan 1 collaboration

Samuel L Drew 1 collaboration

Elaine Ginn 1 collaboration

Amber T Pham 1 collaboration

Julia Kratky 1 collaboration

Daniel Eggerichs 1 collaboration

Thomas Heine 1 collaboration

Sarah Hofmann 1 collaboration

Philipp Sowa 1 collaboration

Dirk Tischler 1 collaboration

Shujing Xu 1 collaboration

Andhika B Mahardhika 1 collaboration

Christin Vielmuth 1 collaboration

Inken Kaja Schwerin 1 collaboration

Angelo Oneto 1 collaboration

Ghazl Al Hamwi 1 collaboration

Nadine Krüger 1 collaboration

Rasha Abu Shamleh 1 collaboration

Thanigaimalai Pillaiyar 1 collaboration

Myoung Kyu Lee 1 collaboration

Hye-Yeon Jang 1 collaboration

Inseong Jo 1 collaboration

Chun-Chiao Yang 1 collaboration

Chunkyu Ko 1 collaboration

Shuo Wang 1 collaboration

Kai Tang 1 collaboration

Junyi Li 1 collaboration

Manyu Gu 1 collaboration

Meehyein Kim 1 collaboration