Design, Synthesis, and Biological Evaluation of Trisubstituted Piperazine Derivatives as Noncovalent Severe Acute Respiratory Syndrome Coronavirus 2 Main Protease Inhibitors with Improved Antiviral Activity and Favorable Druggability.

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
14 Dec 2023
Historique:
pubmed: 22 11 2023
medline: 22 11 2023
entrez: 22 11 2023
Statut: ppublish

Résumé

The ongoing transmission of SARS-CoV-2 necessitates the development of additional potent antiviral agents capable of combating the current highly infectious variants and future coronaviruses. Here, we present the discovery of potent nonpeptide main protease (M

Identifiants

DOI: 10.1021/acs.jmedchem.3c01876 PMID: 37992202
pubmed: 37992202
doi: 10.1021/acs.jmedchem.3c01876
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

16426-16440

Auteurs

Shenghua Gao (S)

Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Ji'nan 250012, China.
Shenzhen Research Institute of Shandong University, A301 Virtual University Park in South District of Shenzhen, Shenzhen, Guangdong 518057, PR China.

Letian Song (L)

Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Ji'nan 250012, China.

Katharina Sylvester (K)

PharmaCenter Bonn & Pharmaceutical Institute, Department of Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, 53113 Bonn, Germany.

Beatrice Mercorelli (B)

Department of Molecular Medicine, University of Padua, Via Gabelli 63, 35121 Padua, Italy.
ORCID: 0000-0003-0654-8045

Arianna Loregian (A)

Department of Molecular Medicine, University of Padua, Via Gabelli 63, 35121 Padua, Italy.
ORCID: 0000-0002-8900-861X

Karoly Toth (K)

Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St. Louis, Missouri 63103, United States.

Renato H Weiße (RH)

Institute of Bioanalytical Chemistry, Center for Biotechnology and Biomedicine, Leipzig University, Deutscher Platz 5, Leipzig 04103, Germany.
ORCID: 0000-0002-1736-8085

Abibe Useini (A)

Institute of Bioanalytical Chemistry, Center for Biotechnology and Biomedicine, Leipzig University, Deutscher Platz 5, Leipzig 04103, Germany.
ORCID: 0000-0001-9183-9634

Norbert Sträter (N)

Institute of Bioanalytical Chemistry, Center for Biotechnology and Biomedicine, Leipzig University, Deutscher Platz 5, Leipzig 04103, Germany.
ORCID: 0000-0002-2001-0500

Mianling Yang (M)

Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Ji'nan 250012, China.

Bing Ye (B)

Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Ji'nan 250012, China.

Ann E Tollefson (AE)

Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St. Louis, Missouri 63103, United States.

Christa E Müller (CE)

PharmaCenter Bonn & Pharmaceutical Institute, Department of Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, 53113 Bonn, Germany.
ORCID: 0000-0002-0013-6624

Xinyong Liu (X)

Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Ji'nan 250012, China.
ORCID: 0000-0002-7302-2214

Peng Zhan (P)

Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Ji'nan 250012, China.
ORCID: 0000-0002-9675-6026

Classifications MeSH