Jenny Desantis

Affiliations

Department of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, Italy.
Department of Chemistry, Biology, and Biotechnology, University of Perugia, 06123 Perugia, Italy.

Publications (18)

1,2,4-Triazolo[1,5-

Molecules (Basel, Switzerland)

Avec: Jenny Desantis , Serena Massari , Angela Corona , Andrea Astolfi , Stefano Sabatini , Giuseppe Manfroni , Deborah Palazzotti , Violetta Cecchetti , Christophe Pannecouque , Enzo Tramontano , Oriana Tabarrini

Indomethacin-based PROTACs as pan-coronavirus antiviral agents.

European journal of medicinal chemistry

Avec: Jenny Desantis , Beatrice Mercorelli , Marta Celegato , Federico Croci , Alessandro Bazzacco , Massimo Baroni , Lydia Siragusa , Gabriele Cruciani , Arianna Loregian , Laura Goracci

Automatic Identification of Lansoprazole Degradants under Stress Conditions by LC-HRMS with MassChemSite and WebChembase.

Journal of chemical information and modeling

Avec: Stefano Bonciarelli , Jenny Desantis , Laura Goracci , Lydia Siragusa , Ismael Zamora , Elisabeth Ortega-Carrasco

Use of ionic liquids in amidation reactions for proteolysis targeting chimera synthesis.

Organic & biomolecular chemistry

Avec: Michela Eleuteri , Jenny Desantis , Gabriele Cruciani , Raimondo Germani , Laura Goracci

CROMATIC:

Journal of chemical information and modeling

Avec: Lydia Siragusa , Gabriele Menna , Fabrizio Buratta , Massimo Baroni , Jenny Desantis , Gabriele Cruciani , Laura Goracci

Discovery of novel SARS-CoV-2 inhibitors targeting the main protease M

Antiviral research

Avec: Beatrice Mercorelli , Jenny Desantis , Marta Celegato , Alessandro Bazzacco , Lydia Siragusa , Paolo Benedetti , Michela Eleuteri , Federico Croci , Gabriele Cruciani , Laura Goracci , Arianna Loregian

Understanding the Metabolism of Proteolysis Targeting Chimeras (PROTACs): The Next Step toward Pharmaceutical Applications.

Journal of medicinal chemistry

Avec: Laura Goracci , Jenny Desantis , Aurora Valeri , Beatrice Castellani , Michela Eleuteri , Gabriele Cruciani

PROTACs bearing piperazine-containing linkers: what effect on their protonation state?

RSC advances

Avec: Jenny Desantis , Andrea Mammoli , Michela Eleuteri , Alice Coletti , Federico Croci , Antonio Macchiarulo , Laura Goracci

From cycloheptathiophene-3-carboxamide to oxazinone-based derivatives as allosteric HIV-1 ribonuclease H inhibitors.

Journal of enzyme inhibition and medicinal chemistry

Avec: Serena Massari , Angela Corona , Simona Distinto , Jenny Desantis , Alessia Caredda , Stefano Sabatini , Giuseppe Manfroni , Tommaso Felicetti , Violetta Cecchetti , Christophe Pannecouque , Elias Maccioni , Enzo Tramontano , Oriana Tabarrini

Potent and broad-spectrum cycloheptathiophene-3-carboxamide compounds that target the PA-PB1 interaction of influenza virus RNA polymerase and possess a high barrier to drug resistance.

Antiviral research

Avec: Giulio Nannetti , Serena Massari , Beatrice Mercorelli , Chiara Bertagnin , Jenny Desantis , Giorgio Palù , Oriana Tabarrini , Arianna Loregian

Inhibition of Influenza Virus Polymerase by Interfering with Its Protein-Protein Interactions.

ACS infectious diseases

Avec: Serena Massari , Jenny Desantis , Maria Giulia Nizi , Violetta Cecchetti , Oriana Tabarrini

MassChemSite for In-Depth Forced Degradation Analysis of PARP Inhibitors Olaparib, Rucaparib, and Niraparib.

ACS omega

Avec: Stefano Bonciarelli , Jenny Desantis , Simone Cerquiglini , Laura Goracci

Antitubercular polyhalogenated phenothiazines and phenoselenazine with reduced binding to CNS receptors.

European journal of medicinal chemistry

Avec: Maria Giulia Nizi , Jenny Desantis , Yoshio Nakatani , Serena Massari , Maria Angela Mazzarella , Gauri Shetye , Stefano Sabatini , Maria Letizia Barreca , Giuseppe Manfroni , Tommaso Felicetti , Rowena Rushton-Green , Kiel Hards , Gniewomir Latacz , Grzegorz Satała , Andrzej J Bojarski , Violetta Cecchetti , Michal H Kolář , Jadwiga Handzlik , Gregory M Cook , Scott G Franzblau , Oriana Tabarrini

An overview on small molecules acting as broad-spectrum agents for yellow fever infection.

Expert opinion on drug discovery

Avec: Jenny Desantis , Tommaso Felicetti , Rolando Cannalire

Exploiting ELIOT for Scaffold-Repurposing Opportunities: TRIM33 a Possible Novel E3 Ligase to Expand the Toolbox for PROTAC Design.

International journal of molecular sciences

Avec: Tommaso Palomba , Giusy Tassone , Carmine Vacca , Matteo Bartalucci , Aurora Valeri , Cecilia Pozzi , Simon Cross , Lydia Siragusa , Jenny Desantis

Design, synthesis, and biological evaluation of first-in-class indomethacin-based PROTACs degrading SARS-CoV-2 main protease and with broad-spectrum antiviral activity.

European journal of medicinal chemistry

Avec: Jenny Desantis , Alessandro Bazzacco , Michela Eleuteri , Sara Tuci , Elisa Bianconi , Antonio Macchiarulo , Beatrice Mercorelli , Arianna Loregian , Laura Goracci

Between Theory and Practice: Computational/Experimental Integrated Approaches to Understand the Solubility and Lipophilicity of PROTACs.

Journal of medicinal chemistry

Avec: Andrea Venturi , Stefano Di Bona , Jenny Desantis , Michela Eleuteri , Matteo Bartalucci , Massimo Baroni , Paolo Benedetti , Laura Goracci , Gabriele Cruciani

Effects of MTX-23, a Novel PROTAC of Androgen Receptor Splice Variant-7 and Androgen Receptor, on CRPC Resistant to Second-Line Antiandrogen Therapy.

Molecular cancer therapeutics

Avec: Geun Taek Lee , Naoya Nagaya , Jenny Desantis , Kiran Madura , Hatem E Sabaawy , Wun-Jae Kim , Roy J Vaz , Gabriele Cruciani , Isaac Yi Kim

Réseau de co-auteurs

Laura Goracci 10 collaborations

Gabriele Cruciani 7 collaborations

Michela Eleuteri 6 collaborations

Serena Massari 5 collaborations

Oriana Tabarrini 5 collaborations

Lydia Siragusa 5 collaborations

Violetta Cecchetti 4 collaborations

Beatrice Mercorelli 4 collaborations

Arianna Loregian 4 collaborations

Stefano Sabatini 3 collaborations

Giuseppe Manfroni 3 collaborations

Federico Croci 3 collaborations

Alessandro Bazzacco 3 collaborations

Massimo Baroni 3 collaborations

Tommaso Felicetti 3 collaborations

Angela Corona 2 collaborations

Christophe Pannecouque 2 collaborations

Enzo Tramontano 2 collaborations

Marta Celegato 2 collaborations

Stefano Bonciarelli 2 collaborations

Paolo Benedetti 2 collaborations

Aurora Valeri 2 collaborations

Antonio Macchiarulo 2 collaborations

Maria Giulia Nizi 2 collaborations

Matteo Bartalucci 2 collaborations

Andrea Astolfi 1 collaboration

Deborah Palazzotti 1 collaboration

Ismael Zamora 1 collaboration

Elisabeth Ortega-Carrasco 1 collaboration

Raimondo Germani 1 collaboration

Gabriele Menna 1 collaboration

Fabrizio Buratta 1 collaboration

Beatrice Castellani 1 collaboration

Andrea Mammoli 1 collaboration

Alice Coletti 1 collaboration

Simona Distinto 1 collaboration

Alessia Caredda 1 collaboration

Elias Maccioni 1 collaboration

Giulio Nannetti 1 collaboration

Chiara Bertagnin 1 collaboration

Giorgio Palù 1 collaboration

Simone Cerquiglini 1 collaboration

Yoshio Nakatani 1 collaboration

Maria Angela Mazzarella 1 collaboration

Gauri Shetye 1 collaboration

Maria Letizia Barreca 1 collaboration

Rowena Rushton-Green 1 collaboration

Kiel Hards 1 collaboration

Gniewomir Latacz 1 collaboration

Grzegorz Satała 1 collaboration

Andrzej J Bojarski 1 collaboration

Michal H Kolář 1 collaboration

Jadwiga Handzlik 1 collaboration

Gregory M Cook 1 collaboration

Scott G Franzblau 1 collaboration

Rolando Cannalire 1 collaboration

Tommaso Palomba 1 collaboration

Giusy Tassone 1 collaboration

Carmine Vacca 1 collaboration

Cecilia Pozzi 1 collaboration

Simon Cross 1 collaboration

Sara Tuci 1 collaboration

Elisa Bianconi 1 collaboration

Andrea Venturi 1 collaboration

Stefano Di Bona 1 collaboration

Geun Taek Lee 1 collaboration

Naoya Nagaya 1 collaboration

Kiran Madura 1 collaboration

Hatem E Sabaawy 1 collaboration

Wun-Jae Kim 1 collaboration

Roy J Vaz 1 collaboration

Isaac Yi Kim 1 collaboration