Trial of Endovascular Treatment of Acute Basilar-Artery Occlusion.


Journal

The New England journal of medicine
ISSN: 1533-4406
Titre abrégé: N Engl J Med
Pays: United States
ID NLM: 0255562

Informations de publication

Date de publication:
13 10 2022
Historique:
entrez: 14 10 2022
pubmed: 15 10 2022
medline: 19 10 2022
Statut: ppublish

Résumé

Data from trials investigating the effects and risks of endovascular thrombectomy for the treatment of stroke due to basilar-artery occlusion are limited. We conducted a multicenter, prospective, randomized, controlled trial of endovascular thrombectomy for basilar-artery occlusion at 36 centers in China. Patients were assigned, in a 2:1 ratio, within 12 hours after the estimated time of basilar-artery occlusion to receive endovascular thrombectomy or best medical care (control). The primary outcome was good functional status, defined as a score of 0 to 3 on the modified Rankin scale (range, 0 [no symptoms] to 6 [death]), at 90 days. Secondary outcomes included a modified Rankin scale score of 0 to 2, distribution across the modified Rankin scale score categories, and quality of life. Safety outcomes included symptomatic intracranial hemorrhage at 24 to 72 hours, 90-day mortality, and procedural complications. Of the 507 patients who underwent screening, 340 were in the intention-to-treat population, with 226 assigned to the thrombectomy group and 114 to the control group. Intravenous thrombolysis was used in 31% of the patients in the thrombectomy group and in 34% of those in the control group. Good functional status at 90 days occurred in 104 patients (46%) in the thrombectomy group and in 26 (23%) in the control group (adjusted rate ratio, 2.06; 95% confidence interval [CI], 1.46 to 2.91, P<0.001). Symptomatic intracranial hemorrhage occurred in 12 patients (5%) in the thrombectomy group and in none in the control group. Results for the secondary clinical and imaging outcomes were generally in the same direction as those for the primary outcome. Mortality at 90 days was 37% in the thrombectomy group and 55% in the control group (adjusted risk ratio, 0.66; 95% CI, 0.52 to 0.82). Procedural complications occurred in 14% of the patients in the thrombectomy group, including one death due to arterial perforation. In a trial involving Chinese patients with basilar-artery occlusion, approximately one third of whom received intravenous thrombolysis, endovascular thrombectomy within 12 hours after stroke onset led to better functional outcomes at 90 days than best medical care but was associated with procedural complications and intracerebral hemorrhage. (Funded by the Program for Innovative Research Team of the First Affiliated Hospital of USTC and others; ATTENTION ClinicalTrials.gov number, NCT04751708.).

Sections du résumé

BACKGROUND
Data from trials investigating the effects and risks of endovascular thrombectomy for the treatment of stroke due to basilar-artery occlusion are limited.
METHODS
We conducted a multicenter, prospective, randomized, controlled trial of endovascular thrombectomy for basilar-artery occlusion at 36 centers in China. Patients were assigned, in a 2:1 ratio, within 12 hours after the estimated time of basilar-artery occlusion to receive endovascular thrombectomy or best medical care (control). The primary outcome was good functional status, defined as a score of 0 to 3 on the modified Rankin scale (range, 0 [no symptoms] to 6 [death]), at 90 days. Secondary outcomes included a modified Rankin scale score of 0 to 2, distribution across the modified Rankin scale score categories, and quality of life. Safety outcomes included symptomatic intracranial hemorrhage at 24 to 72 hours, 90-day mortality, and procedural complications.
RESULTS
Of the 507 patients who underwent screening, 340 were in the intention-to-treat population, with 226 assigned to the thrombectomy group and 114 to the control group. Intravenous thrombolysis was used in 31% of the patients in the thrombectomy group and in 34% of those in the control group. Good functional status at 90 days occurred in 104 patients (46%) in the thrombectomy group and in 26 (23%) in the control group (adjusted rate ratio, 2.06; 95% confidence interval [CI], 1.46 to 2.91, P<0.001). Symptomatic intracranial hemorrhage occurred in 12 patients (5%) in the thrombectomy group and in none in the control group. Results for the secondary clinical and imaging outcomes were generally in the same direction as those for the primary outcome. Mortality at 90 days was 37% in the thrombectomy group and 55% in the control group (adjusted risk ratio, 0.66; 95% CI, 0.52 to 0.82). Procedural complications occurred in 14% of the patients in the thrombectomy group, including one death due to arterial perforation.
CONCLUSIONS
In a trial involving Chinese patients with basilar-artery occlusion, approximately one third of whom received intravenous thrombolysis, endovascular thrombectomy within 12 hours after stroke onset led to better functional outcomes at 90 days than best medical care but was associated with procedural complications and intracerebral hemorrhage. (Funded by the Program for Innovative Research Team of the First Affiliated Hospital of USTC and others; ATTENTION ClinicalTrials.gov number, NCT04751708.).

Identifiants

pubmed: 36239644
doi: 10.1056/NEJMoa2206317
doi:

Substances chimiques

Fibrinolytic Agents 0

Banques de données

ClinicalTrials.gov
['NCT04751708']

Types de publication

Comparative Study Journal Article Multicenter Study Randomized Controlled Trial Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1361-1372

Investigateurs

Wei Hu (W)
Xinfeng Liu (X)
Guoping Wang (G)
Raul G Nogueira (RG)
Adnan I Qureshi (AI)
Blaise W Baxter (BW)
Gelin Xu (G)
Xiaoyan Yan (X)
Feng Gao (F)
Liqun Jiao (L)
Sen Qun (S)
Zi Wang (Z)
Juan Chen (J)
Ruidong Ye (R)
Yongwei Zhang (Y)
Cangjun Wu (C)
Rui Li (R)
Chuanqing Fang (C)
Kexue Deng (K)
Shuya Yuan (S)
Menglong Zheng (M)
Hongbing Chen (H)
Guang Zhang (G)
Wei Bao (W)
Hongxing Han (H)
Guangxiong Yuan (G)
Changming Wen (C)
Peiyang Zhou (P)
Wenhuo Chen (W)
Guoyong Zeng (G)
Hui Xu (H)
Yuwen Li (Y)
Zhengfei Ma (Z)
Chuanqing Yu (C)
Junfeng Su (J)
Zhiming Zhou (Z)
Zhongjun Chen (Z)
Geng Liao (G)
Yaxuan Sun (Y)
Youquan Ren (Y)
Hui Zhang (H)
Jie Chen (J)
Xincan Yue (X)
Xiuyao Ma (X)
GuoDong Xiao (G)
Li Wang (L)
Rui Liu (R)
Weimin Yang (W)
Wenhua Liu (W)
Yong Liu (Y)
Fuqiang Guo (F)
Xueli Cai (X)
Bo Yin (B)
Jinglun Li (J)
Pu Fang (P)
Chunyun Shen (C)
Chuyuan Ni (C)
Hui Wang (H)
Liang Liu (L)
Kai Li (K)
Tao Cui (T)
Hao Wang (H)
Jun Gao (J)
Tingyu Yi (T)
Youmeng Wang (Y)
Tao Wang (T)
Xueying Shi (X)
Zhihua Cao (Z)
Chen Long (C)
Li Chen (L)
Chi Zhang (C)
Gichao Zhai (G)
Xia Zhang (X)
Xiushan Liang (X)
Qingsong Li (Q)
Yuhan Meng (Y)
Jianbo Tao (J)
Zhenzhu Zhu (Z)
Yuedong Cheng (Y)
Meng Zhang (M)
Tong Zhou (T)
Jing Wang (J)
Yali Zhang (Y)

Commentaires et corrections

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Informations de copyright

Copyright © 2022 Massachusetts Medical Society.

Auteurs

Chunrong Tao (C)

From the Stroke Center and Department of Neurology, First Affiliated Hospital of the University of Science and Technology of China (USTC), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (C.T., Y.Z., J. Sun, Li Wang, C.Z., T.L., J. Song, R. Li, P.X., Y.Y., G.W., X.L., W.H.), the Department of Neurology, Linyi People's Hospital, Linyi (H.H.), the Emergency Department, Xiangtan Central Hospital, Xiangtan (G.Y.), the Department of Neurology, Nanyang Central Hospital, Nanyang (C.W.), the Department of Neurology, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang (P.Z.), the Department of Neurology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou (W.C.), the Department of Neurology, Ganzhou People's Hospital, Ganzhou (G.Z.), the Department of Neurology, Heze Municipal Hospital, Heze (Y. Li), the Department of Neurology, Suzhou Hospital of Anhui Medical University (Z.M.), and the Department of Neurology and Clinical Research Center of Neurologic Disease, Second Affiliated Hospital of Soochow University (G.X.), Suzhou, the Department of Neurology, First Affiliated Hospital of Anhui University of Science and Technology, First People's Hospital of Huainan, Huainan (C.Y.), the Department of Neurology, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou (J. Su), the Department of Neurology, Yijishan Hospital of Wannan Medical College, Wuhu (Z.Z.), the Department of Neurointervention, Dalian Municipal Central Hospital Affiliated with Dalian Medical University, Dalian (Z.C.), the Department of Neurology, Maoming People's Hospital, Maoming (G.L.), the Department of Neurology, Shanxi Provincial People's Hospital, Taiyuan (Y.S.), the Department of Neurology, Linquan Country People's Hospital, Linquan (Y.R.), the Department of Neurosurgery, Second Affiliated Hospital of Bengbu Medical College, Bengbu (H.Z.), the Department of Neurosurgery, Tongling People's Hospital, Tongling (J.C.), the Department of Neurosurgery, Zhoukou Central Hospital of Henan University, Zhoukou (X.Y.), the Department of Neurology, Zigong Third People's Hospital, Zigong (Li Wang), the Department of Neurology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing (R. Liu, X.L.), the Department of Neurology, Wuhan No. 1 Hospital, Wuhan (W.L.), and the Department of Neurology, Lu'an Hospital of Anhui Medical University, Lu'an (Y. Liu) - all in China; the UPMC Stroke Institute, Department of Neurology and Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh (R.G.N.), and Lehigh Valley Health Network, Allentown (B.B.) - both in Pennsylvania; and the Zeenat Qureshi Stroke Institute and Department of Neurology, University of Missouri, Columbia (A.I.Q.).

Raul G Nogueira (RG)

From the Stroke Center and Department of Neurology, First Affiliated Hospital of the University of Science and Technology of China (USTC), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (C.T., Y.Z., J. Sun, Li Wang, C.Z., T.L., J. Song, R. Li, P.X., Y.Y., G.W., X.L., W.H.), the Department of Neurology, Linyi People's Hospital, Linyi (H.H.), the Emergency Department, Xiangtan Central Hospital, Xiangtan (G.Y.), the Department of Neurology, Nanyang Central Hospital, Nanyang (C.W.), the Department of Neurology, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang (P.Z.), the Department of Neurology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou (W.C.), the Department of Neurology, Ganzhou People's Hospital, Ganzhou (G.Z.), the Department of Neurology, Heze Municipal Hospital, Heze (Y. Li), the Department of Neurology, Suzhou Hospital of Anhui Medical University (Z.M.), and the Department of Neurology and Clinical Research Center of Neurologic Disease, Second Affiliated Hospital of Soochow University (G.X.), Suzhou, the Department of Neurology, First Affiliated Hospital of Anhui University of Science and Technology, First People's Hospital of Huainan, Huainan (C.Y.), the Department of Neurology, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou (J. Su), the Department of Neurology, Yijishan Hospital of Wannan Medical College, Wuhu (Z.Z.), the Department of Neurointervention, Dalian Municipal Central Hospital Affiliated with Dalian Medical University, Dalian (Z.C.), the Department of Neurology, Maoming People's Hospital, Maoming (G.L.), the Department of Neurology, Shanxi Provincial People's Hospital, Taiyuan (Y.S.), the Department of Neurology, Linquan Country People's Hospital, Linquan (Y.R.), the Department of Neurosurgery, Second Affiliated Hospital of Bengbu Medical College, Bengbu (H.Z.), the Department of Neurosurgery, Tongling People's Hospital, Tongling (J.C.), the Department of Neurosurgery, Zhoukou Central Hospital of Henan University, Zhoukou (X.Y.), the Department of Neurology, Zigong Third People's Hospital, Zigong (Li Wang), the Department of Neurology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing (R. Liu, X.L.), the Department of Neurology, Wuhan No. 1 Hospital, Wuhan (W.L.), and the Department of Neurology, Lu'an Hospital of Anhui Medical University, Lu'an (Y. Liu) - all in China; the UPMC Stroke Institute, Department of Neurology and Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh (R.G.N.), and Lehigh Valley Health Network, Allentown (B.B.) - both in Pennsylvania; and the Zeenat Qureshi Stroke Institute and Department of Neurology, University of Missouri, Columbia (A.I.Q.).

Yuyou Zhu (Y)

From the Stroke Center and Department of Neurology, First Affiliated Hospital of the University of Science and Technology of China (USTC), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (C.T., Y.Z., J. Sun, Li Wang, C.Z., T.L., J. Song, R. Li, P.X., Y.Y., G.W., X.L., W.H.), the Department of Neurology, Linyi People's Hospital, Linyi (H.H.), the Emergency Department, Xiangtan Central Hospital, Xiangtan (G.Y.), the Department of Neurology, Nanyang Central Hospital, Nanyang (C.W.), the Department of Neurology, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang (P.Z.), the Department of Neurology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou (W.C.), the Department of Neurology, Ganzhou People's Hospital, Ganzhou (G.Z.), the Department of Neurology, Heze Municipal Hospital, Heze (Y. Li), the Department of Neurology, Suzhou Hospital of Anhui Medical University (Z.M.), and the Department of Neurology and Clinical Research Center of Neurologic Disease, Second Affiliated Hospital of Soochow University (G.X.), Suzhou, the Department of Neurology, First Affiliated Hospital of Anhui University of Science and Technology, First People's Hospital of Huainan, Huainan (C.Y.), the Department of Neurology, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou (J. Su), the Department of Neurology, Yijishan Hospital of Wannan Medical College, Wuhu (Z.Z.), the Department of Neurointervention, Dalian Municipal Central Hospital Affiliated with Dalian Medical University, Dalian (Z.C.), the Department of Neurology, Maoming People's Hospital, Maoming (G.L.), the Department of Neurology, Shanxi Provincial People's Hospital, Taiyuan (Y.S.), the Department of Neurology, Linquan Country People's Hospital, Linquan (Y.R.), the Department of Neurosurgery, Second Affiliated Hospital of Bengbu Medical College, Bengbu (H.Z.), the Department of Neurosurgery, Tongling People's Hospital, Tongling (J.C.), the Department of Neurosurgery, Zhoukou Central Hospital of Henan University, Zhoukou (X.Y.), the Department of Neurology, Zigong Third People's Hospital, Zigong (Li Wang), the Department of Neurology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing (R. Liu, X.L.), the Department of Neurology, Wuhan No. 1 Hospital, Wuhan (W.L.), and the Department of Neurology, Lu'an Hospital of Anhui Medical University, Lu'an (Y. Liu) - all in China; the UPMC Stroke Institute, Department of Neurology and Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh (R.G.N.), and Lehigh Valley Health Network, Allentown (B.B.) - both in Pennsylvania; and the Zeenat Qureshi Stroke Institute and Department of Neurology, University of Missouri, Columbia (A.I.Q.).

Jun Sun (J)

From the Stroke Center and Department of Neurology, First Affiliated Hospital of the University of Science and Technology of China (USTC), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (C.T., Y.Z., J. Sun, Li Wang, C.Z., T.L., J. Song, R. Li, P.X., Y.Y., G.W., X.L., W.H.), the Department of Neurology, Linyi People's Hospital, Linyi (H.H.), the Emergency Department, Xiangtan Central Hospital, Xiangtan (G.Y.), the Department of Neurology, Nanyang Central Hospital, Nanyang (C.W.), the Department of Neurology, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang (P.Z.), the Department of Neurology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou (W.C.), the Department of Neurology, Ganzhou People's Hospital, Ganzhou (G.Z.), the Department of Neurology, Heze Municipal Hospital, Heze (Y. Li), the Department of Neurology, Suzhou Hospital of Anhui Medical University (Z.M.), and the Department of Neurology and Clinical Research Center of Neurologic Disease, Second Affiliated Hospital of Soochow University (G.X.), Suzhou, the Department of Neurology, First Affiliated Hospital of Anhui University of Science and Technology, First People's Hospital of Huainan, Huainan (C.Y.), the Department of Neurology, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou (J. Su), the Department of Neurology, Yijishan Hospital of Wannan Medical College, Wuhu (Z.Z.), the Department of Neurointervention, Dalian Municipal Central Hospital Affiliated with Dalian Medical University, Dalian (Z.C.), the Department of Neurology, Maoming People's Hospital, Maoming (G.L.), the Department of Neurology, Shanxi Provincial People's Hospital, Taiyuan (Y.S.), the Department of Neurology, Linquan Country People's Hospital, Linquan (Y.R.), the Department of Neurosurgery, Second Affiliated Hospital of Bengbu Medical College, Bengbu (H.Z.), the Department of Neurosurgery, Tongling People's Hospital, Tongling (J.C.), the Department of Neurosurgery, Zhoukou Central Hospital of Henan University, Zhoukou (X.Y.), the Department of Neurology, Zigong Third People's Hospital, Zigong (Li Wang), the Department of Neurology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing (R. Liu, X.L.), the Department of Neurology, Wuhan No. 1 Hospital, Wuhan (W.L.), and the Department of Neurology, Lu'an Hospital of Anhui Medical University, Lu'an (Y. Liu) - all in China; the UPMC Stroke Institute, Department of Neurology and Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh (R.G.N.), and Lehigh Valley Health Network, Allentown (B.B.) - both in Pennsylvania; and the Zeenat Qureshi Stroke Institute and Department of Neurology, University of Missouri, Columbia (A.I.Q.).

Hongxing Han (H)

From the Stroke Center and Department of Neurology, First Affiliated Hospital of the University of Science and Technology of China (USTC), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (C.T., Y.Z., J. Sun, Li Wang, C.Z., T.L., J. Song, R. Li, P.X., Y.Y., G.W., X.L., W.H.), the Department of Neurology, Linyi People's Hospital, Linyi (H.H.), the Emergency Department, Xiangtan Central Hospital, Xiangtan (G.Y.), the Department of Neurology, Nanyang Central Hospital, Nanyang (C.W.), the Department of Neurology, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang (P.Z.), the Department of Neurology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou (W.C.), the Department of Neurology, Ganzhou People's Hospital, Ganzhou (G.Z.), the Department of Neurology, Heze Municipal Hospital, Heze (Y. Li), the Department of Neurology, Suzhou Hospital of Anhui Medical University (Z.M.), and the Department of Neurology and Clinical Research Center of Neurologic Disease, Second Affiliated Hospital of Soochow University (G.X.), Suzhou, the Department of Neurology, First Affiliated Hospital of Anhui University of Science and Technology, First People's Hospital of Huainan, Huainan (C.Y.), the Department of Neurology, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou (J. Su), the Department of Neurology, Yijishan Hospital of Wannan Medical College, Wuhu (Z.Z.), the Department of Neurointervention, Dalian Municipal Central Hospital Affiliated with Dalian Medical University, Dalian (Z.C.), the Department of Neurology, Maoming People's Hospital, Maoming (G.L.), the Department of Neurology, Shanxi Provincial People's Hospital, Taiyuan (Y.S.), the Department of Neurology, Linquan Country People's Hospital, Linquan (Y.R.), the Department of Neurosurgery, Second Affiliated Hospital of Bengbu Medical College, Bengbu (H.Z.), the Department of Neurosurgery, Tongling People's Hospital, Tongling (J.C.), the Department of Neurosurgery, Zhoukou Central Hospital of Henan University, Zhoukou (X.Y.), the Department of Neurology, Zigong Third People's Hospital, Zigong (Li Wang), the Department of Neurology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing (R. Liu, X.L.), the Department of Neurology, Wuhan No. 1 Hospital, Wuhan (W.L.), and the Department of Neurology, Lu'an Hospital of Anhui Medical University, Lu'an (Y. Liu) - all in China; the UPMC Stroke Institute, Department of Neurology and Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh (R.G.N.), and Lehigh Valley Health Network, Allentown (B.B.) - both in Pennsylvania; and the Zeenat Qureshi Stroke Institute and Department of Neurology, University of Missouri, Columbia (A.I.Q.).

Guangxiong Yuan (G)

From the Stroke Center and Department of Neurology, First Affiliated Hospital of the University of Science and Technology of China (USTC), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (C.T., Y.Z., J. Sun, Li Wang, C.Z., T.L., J. Song, R. Li, P.X., Y.Y., G.W., X.L., W.H.), the Department of Neurology, Linyi People's Hospital, Linyi (H.H.), the Emergency Department, Xiangtan Central Hospital, Xiangtan (G.Y.), the Department of Neurology, Nanyang Central Hospital, Nanyang (C.W.), the Department of Neurology, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang (P.Z.), the Department of Neurology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou (W.C.), the Department of Neurology, Ganzhou People's Hospital, Ganzhou (G.Z.), the Department of Neurology, Heze Municipal Hospital, Heze (Y. Li), the Department of Neurology, Suzhou Hospital of Anhui Medical University (Z.M.), and the Department of Neurology and Clinical Research Center of Neurologic Disease, Second Affiliated Hospital of Soochow University (G.X.), Suzhou, the Department of Neurology, First Affiliated Hospital of Anhui University of Science and Technology, First People's Hospital of Huainan, Huainan (C.Y.), the Department of Neurology, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou (J. Su), the Department of Neurology, Yijishan Hospital of Wannan Medical College, Wuhu (Z.Z.), the Department of Neurointervention, Dalian Municipal Central Hospital Affiliated with Dalian Medical University, Dalian (Z.C.), the Department of Neurology, Maoming People's Hospital, Maoming (G.L.), the Department of Neurology, Shanxi Provincial People's Hospital, Taiyuan (Y.S.), the Department of Neurology, Linquan Country People's Hospital, Linquan (Y.R.), the Department of Neurosurgery, Second Affiliated Hospital of Bengbu Medical College, Bengbu (H.Z.), the Department of Neurosurgery, Tongling People's Hospital, Tongling (J.C.), the Department of Neurosurgery, Zhoukou Central Hospital of Henan University, Zhoukou (X.Y.), the Department of Neurology, Zigong Third People's Hospital, Zigong (Li Wang), the Department of Neurology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing (R. Liu, X.L.), the Department of Neurology, Wuhan No. 1 Hospital, Wuhan (W.L.), and the Department of Neurology, Lu'an Hospital of Anhui Medical University, Lu'an (Y. Liu) - all in China; the UPMC Stroke Institute, Department of Neurology and Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh (R.G.N.), and Lehigh Valley Health Network, Allentown (B.B.) - both in Pennsylvania; and the Zeenat Qureshi Stroke Institute and Department of Neurology, University of Missouri, Columbia (A.I.Q.).

Changming Wen (C)

From the Stroke Center and Department of Neurology, First Affiliated Hospital of the University of Science and Technology of China (USTC), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (C.T., Y.Z., J. Sun, Li Wang, C.Z., T.L., J. Song, R. Li, P.X., Y.Y., G.W., X.L., W.H.), the Department of Neurology, Linyi People's Hospital, Linyi (H.H.), the Emergency Department, Xiangtan Central Hospital, Xiangtan (G.Y.), the Department of Neurology, Nanyang Central Hospital, Nanyang (C.W.), the Department of Neurology, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang (P.Z.), the Department of Neurology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou (W.C.), the Department of Neurology, Ganzhou People's Hospital, Ganzhou (G.Z.), the Department of Neurology, Heze Municipal Hospital, Heze (Y. Li), the Department of Neurology, Suzhou Hospital of Anhui Medical University (Z.M.), and the Department of Neurology and Clinical Research Center of Neurologic Disease, Second Affiliated Hospital of Soochow University (G.X.), Suzhou, the Department of Neurology, First Affiliated Hospital of Anhui University of Science and Technology, First People's Hospital of Huainan, Huainan (C.Y.), the Department of Neurology, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou (J. Su), the Department of Neurology, Yijishan Hospital of Wannan Medical College, Wuhu (Z.Z.), the Department of Neurointervention, Dalian Municipal Central Hospital Affiliated with Dalian Medical University, Dalian (Z.C.), the Department of Neurology, Maoming People's Hospital, Maoming (G.L.), the Department of Neurology, Shanxi Provincial People's Hospital, Taiyuan (Y.S.), the Department of Neurology, Linquan Country People's Hospital, Linquan (Y.R.), the Department of Neurosurgery, Second Affiliated Hospital of Bengbu Medical College, Bengbu (H.Z.), the Department of Neurosurgery, Tongling People's Hospital, Tongling (J.C.), the Department of Neurosurgery, Zhoukou Central Hospital of Henan University, Zhoukou (X.Y.), the Department of Neurology, Zigong Third People's Hospital, Zigong (Li Wang), the Department of Neurology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing (R. Liu, X.L.), the Department of Neurology, Wuhan No. 1 Hospital, Wuhan (W.L.), and the Department of Neurology, Lu'an Hospital of Anhui Medical University, Lu'an (Y. Liu) - all in China; the UPMC Stroke Institute, Department of Neurology and Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh (R.G.N.), and Lehigh Valley Health Network, Allentown (B.B.) - both in Pennsylvania; and the Zeenat Qureshi Stroke Institute and Department of Neurology, University of Missouri, Columbia (A.I.Q.).

Peiyang Zhou (P)

From the Stroke Center and Department of Neurology, First Affiliated Hospital of the University of Science and Technology of China (USTC), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (C.T., Y.Z., J. Sun, Li Wang, C.Z., T.L., J. Song, R. Li, P.X., Y.Y., G.W., X.L., W.H.), the Department of Neurology, Linyi People's Hospital, Linyi (H.H.), the Emergency Department, Xiangtan Central Hospital, Xiangtan (G.Y.), the Department of Neurology, Nanyang Central Hospital, Nanyang (C.W.), the Department of Neurology, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang (P.Z.), the Department of Neurology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou (W.C.), the Department of Neurology, Ganzhou People's Hospital, Ganzhou (G.Z.), the Department of Neurology, Heze Municipal Hospital, Heze (Y. Li), the Department of Neurology, Suzhou Hospital of Anhui Medical University (Z.M.), and the Department of Neurology and Clinical Research Center of Neurologic Disease, Second Affiliated Hospital of Soochow University (G.X.), Suzhou, the Department of Neurology, First Affiliated Hospital of Anhui University of Science and Technology, First People's Hospital of Huainan, Huainan (C.Y.), the Department of Neurology, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou (J. Su), the Department of Neurology, Yijishan Hospital of Wannan Medical College, Wuhu (Z.Z.), the Department of Neurointervention, Dalian Municipal Central Hospital Affiliated with Dalian Medical University, Dalian (Z.C.), the Department of Neurology, Maoming People's Hospital, Maoming (G.L.), the Department of Neurology, Shanxi Provincial People's Hospital, Taiyuan (Y.S.), the Department of Neurology, Linquan Country People's Hospital, Linquan (Y.R.), the Department of Neurosurgery, Second Affiliated Hospital of Bengbu Medical College, Bengbu (H.Z.), the Department of Neurosurgery, Tongling People's Hospital, Tongling (J.C.), the Department of Neurosurgery, Zhoukou Central Hospital of Henan University, Zhoukou (X.Y.), the Department of Neurology, Zigong Third People's Hospital, Zigong (Li Wang), the Department of Neurology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing (R. Liu, X.L.), the Department of Neurology, Wuhan No. 1 Hospital, Wuhan (W.L.), and the Department of Neurology, Lu'an Hospital of Anhui Medical University, Lu'an (Y. Liu) - all in China; the UPMC Stroke Institute, Department of Neurology and Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh (R.G.N.), and Lehigh Valley Health Network, Allentown (B.B.) - both in Pennsylvania; and the Zeenat Qureshi Stroke Institute and Department of Neurology, University of Missouri, Columbia (A.I.Q.).

Wenhuo Chen (W)

From the Stroke Center and Department of Neurology, First Affiliated Hospital of the University of Science and Technology of China (USTC), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (C.T., Y.Z., J. Sun, Li Wang, C.Z., T.L., J. Song, R. Li, P.X., Y.Y., G.W., X.L., W.H.), the Department of Neurology, Linyi People's Hospital, Linyi (H.H.), the Emergency Department, Xiangtan Central Hospital, Xiangtan (G.Y.), the Department of Neurology, Nanyang Central Hospital, Nanyang (C.W.), the Department of Neurology, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang (P.Z.), the Department of Neurology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou (W.C.), the Department of Neurology, Ganzhou People's Hospital, Ganzhou (G.Z.), the Department of Neurology, Heze Municipal Hospital, Heze (Y. Li), the Department of Neurology, Suzhou Hospital of Anhui Medical University (Z.M.), and the Department of Neurology and Clinical Research Center of Neurologic Disease, Second Affiliated Hospital of Soochow University (G.X.), Suzhou, the Department of Neurology, First Affiliated Hospital of Anhui University of Science and Technology, First People's Hospital of Huainan, Huainan (C.Y.), the Department of Neurology, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou (J. Su), the Department of Neurology, Yijishan Hospital of Wannan Medical College, Wuhu (Z.Z.), the Department of Neurointervention, Dalian Municipal Central Hospital Affiliated with Dalian Medical University, Dalian (Z.C.), the Department of Neurology, Maoming People's Hospital, Maoming (G.L.), the Department of Neurology, Shanxi Provincial People's Hospital, Taiyuan (Y.S.), the Department of Neurology, Linquan Country People's Hospital, Linquan (Y.R.), the Department of Neurosurgery, Second Affiliated Hospital of Bengbu Medical College, Bengbu (H.Z.), the Department of Neurosurgery, Tongling People's Hospital, Tongling (J.C.), the Department of Neurosurgery, Zhoukou Central Hospital of Henan University, Zhoukou (X.Y.), the Department of Neurology, Zigong Third People's Hospital, Zigong (Li Wang), the Department of Neurology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing (R. Liu, X.L.), the Department of Neurology, Wuhan No. 1 Hospital, Wuhan (W.L.), and the Department of Neurology, Lu'an Hospital of Anhui Medical University, Lu'an (Y. Liu) - all in China; the UPMC Stroke Institute, Department of Neurology and Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh (R.G.N.), and Lehigh Valley Health Network, Allentown (B.B.) - both in Pennsylvania; and the Zeenat Qureshi Stroke Institute and Department of Neurology, University of Missouri, Columbia (A.I.Q.).

Guoyong Zeng (G)

From the Stroke Center and Department of Neurology, First Affiliated Hospital of the University of Science and Technology of China (USTC), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (C.T., Y.Z., J. Sun, Li Wang, C.Z., T.L., J. Song, R. Li, P.X., Y.Y., G.W., X.L., W.H.), the Department of Neurology, Linyi People's Hospital, Linyi (H.H.), the Emergency Department, Xiangtan Central Hospital, Xiangtan (G.Y.), the Department of Neurology, Nanyang Central Hospital, Nanyang (C.W.), the Department of Neurology, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang (P.Z.), the Department of Neurology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou (W.C.), the Department of Neurology, Ganzhou People's Hospital, Ganzhou (G.Z.), the Department of Neurology, Heze Municipal Hospital, Heze (Y. Li), the Department of Neurology, Suzhou Hospital of Anhui Medical University (Z.M.), and the Department of Neurology and Clinical Research Center of Neurologic Disease, Second Affiliated Hospital of Soochow University (G.X.), Suzhou, the Department of Neurology, First Affiliated Hospital of Anhui University of Science and Technology, First People's Hospital of Huainan, Huainan (C.Y.), the Department of Neurology, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou (J. Su), the Department of Neurology, Yijishan Hospital of Wannan Medical College, Wuhu (Z.Z.), the Department of Neurointervention, Dalian Municipal Central Hospital Affiliated with Dalian Medical University, Dalian (Z.C.), the Department of Neurology, Maoming People's Hospital, Maoming (G.L.), the Department of Neurology, Shanxi Provincial People's Hospital, Taiyuan (Y.S.), the Department of Neurology, Linquan Country People's Hospital, Linquan (Y.R.), the Department of Neurosurgery, Second Affiliated Hospital of Bengbu Medical College, Bengbu (H.Z.), the Department of Neurosurgery, Tongling People's Hospital, Tongling (J.C.), the Department of Neurosurgery, Zhoukou Central Hospital of Henan University, Zhoukou (X.Y.), the Department of Neurology, Zigong Third People's Hospital, Zigong (Li Wang), the Department of Neurology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing (R. Liu, X.L.), the Department of Neurology, Wuhan No. 1 Hospital, Wuhan (W.L.), and the Department of Neurology, Lu'an Hospital of Anhui Medical University, Lu'an (Y. Liu) - all in China; the UPMC Stroke Institute, Department of Neurology and Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh (R.G.N.), and Lehigh Valley Health Network, Allentown (B.B.) - both in Pennsylvania; and the Zeenat Qureshi Stroke Institute and Department of Neurology, University of Missouri, Columbia (A.I.Q.).

Yuwen Li (Y)

From the Stroke Center and Department of Neurology, First Affiliated Hospital of the University of Science and Technology of China (USTC), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (C.T., Y.Z., J. Sun, Li Wang, C.Z., T.L., J. Song, R. Li, P.X., Y.Y., G.W., X.L., W.H.), the Department of Neurology, Linyi People's Hospital, Linyi (H.H.), the Emergency Department, Xiangtan Central Hospital, Xiangtan (G.Y.), the Department of Neurology, Nanyang Central Hospital, Nanyang (C.W.), the Department of Neurology, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang (P.Z.), the Department of Neurology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou (W.C.), the Department of Neurology, Ganzhou People's Hospital, Ganzhou (G.Z.), the Department of Neurology, Heze Municipal Hospital, Heze (Y. Li), the Department of Neurology, Suzhou Hospital of Anhui Medical University (Z.M.), and the Department of Neurology and Clinical Research Center of Neurologic Disease, Second Affiliated Hospital of Soochow University (G.X.), Suzhou, the Department of Neurology, First Affiliated Hospital of Anhui University of Science and Technology, First People's Hospital of Huainan, Huainan (C.Y.), the Department of Neurology, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou (J. Su), the Department of Neurology, Yijishan Hospital of Wannan Medical College, Wuhu (Z.Z.), the Department of Neurointervention, Dalian Municipal Central Hospital Affiliated with Dalian Medical University, Dalian (Z.C.), the Department of Neurology, Maoming People's Hospital, Maoming (G.L.), the Department of Neurology, Shanxi Provincial People's Hospital, Taiyuan (Y.S.), the Department of Neurology, Linquan Country People's Hospital, Linquan (Y.R.), the Department of Neurosurgery, Second Affiliated Hospital of Bengbu Medical College, Bengbu (H.Z.), the Department of Neurosurgery, Tongling People's Hospital, Tongling (J.C.), the Department of Neurosurgery, Zhoukou Central Hospital of Henan University, Zhoukou (X.Y.), the Department of Neurology, Zigong Third People's Hospital, Zigong (Li Wang), the Department of Neurology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing (R. Liu, X.L.), the Department of Neurology, Wuhan No. 1 Hospital, Wuhan (W.L.), and the Department of Neurology, Lu'an Hospital of Anhui Medical University, Lu'an (Y. Liu) - all in China; the UPMC Stroke Institute, Department of Neurology and Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh (R.G.N.), and Lehigh Valley Health Network, Allentown (B.B.) - both in Pennsylvania; and the Zeenat Qureshi Stroke Institute and Department of Neurology, University of Missouri, Columbia (A.I.Q.).

Zhengfei Ma (Z)

From the Stroke Center and Department of Neurology, First Affiliated Hospital of the University of Science and Technology of China (USTC), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (C.T., Y.Z., J. Sun, Li Wang, C.Z., T.L., J. Song, R. Li, P.X., Y.Y., G.W., X.L., W.H.), the Department of Neurology, Linyi People's Hospital, Linyi (H.H.), the Emergency Department, Xiangtan Central Hospital, Xiangtan (G.Y.), the Department of Neurology, Nanyang Central Hospital, Nanyang (C.W.), the Department of Neurology, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang (P.Z.), the Department of Neurology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou (W.C.), the Department of Neurology, Ganzhou People's Hospital, Ganzhou (G.Z.), the Department of Neurology, Heze Municipal Hospital, Heze (Y. Li), the Department of Neurology, Suzhou Hospital of Anhui Medical University (Z.M.), and the Department of Neurology and Clinical Research Center of Neurologic Disease, Second Affiliated Hospital of Soochow University (G.X.), Suzhou, the Department of Neurology, First Affiliated Hospital of Anhui University of Science and Technology, First People's Hospital of Huainan, Huainan (C.Y.), the Department of Neurology, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou (J. Su), the Department of Neurology, Yijishan Hospital of Wannan Medical College, Wuhu (Z.Z.), the Department of Neurointervention, Dalian Municipal Central Hospital Affiliated with Dalian Medical University, Dalian (Z.C.), the Department of Neurology, Maoming People's Hospital, Maoming (G.L.), the Department of Neurology, Shanxi Provincial People's Hospital, Taiyuan (Y.S.), the Department of Neurology, Linquan Country People's Hospital, Linquan (Y.R.), the Department of Neurosurgery, Second Affiliated Hospital of Bengbu Medical College, Bengbu (H.Z.), the Department of Neurosurgery, Tongling People's Hospital, Tongling (J.C.), the Department of Neurosurgery, Zhoukou Central Hospital of Henan University, Zhoukou (X.Y.), the Department of Neurology, Zigong Third People's Hospital, Zigong (Li Wang), the Department of Neurology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing (R. Liu, X.L.), the Department of Neurology, Wuhan No. 1 Hospital, Wuhan (W.L.), and the Department of Neurology, Lu'an Hospital of Anhui Medical University, Lu'an (Y. Liu) - all in China; the UPMC Stroke Institute, Department of Neurology and Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh (R.G.N.), and Lehigh Valley Health Network, Allentown (B.B.) - both in Pennsylvania; and the Zeenat Qureshi Stroke Institute and Department of Neurology, University of Missouri, Columbia (A.I.Q.).

Chuanqing Yu (C)

From the Stroke Center and Department of Neurology, First Affiliated Hospital of the University of Science and Technology of China (USTC), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (C.T., Y.Z., J. Sun, Li Wang, C.Z., T.L., J. Song, R. Li, P.X., Y.Y., G.W., X.L., W.H.), the Department of Neurology, Linyi People's Hospital, Linyi (H.H.), the Emergency Department, Xiangtan Central Hospital, Xiangtan (G.Y.), the Department of Neurology, Nanyang Central Hospital, Nanyang (C.W.), the Department of Neurology, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang (P.Z.), the Department of Neurology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou (W.C.), the Department of Neurology, Ganzhou People's Hospital, Ganzhou (G.Z.), the Department of Neurology, Heze Municipal Hospital, Heze (Y. Li), the Department of Neurology, Suzhou Hospital of Anhui Medical University (Z.M.), and the Department of Neurology and Clinical Research Center of Neurologic Disease, Second Affiliated Hospital of Soochow University (G.X.), Suzhou, the Department of Neurology, First Affiliated Hospital of Anhui University of Science and Technology, First People's Hospital of Huainan, Huainan (C.Y.), the Department of Neurology, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou (J. Su), the Department of Neurology, Yijishan Hospital of Wannan Medical College, Wuhu (Z.Z.), the Department of Neurointervention, Dalian Municipal Central Hospital Affiliated with Dalian Medical University, Dalian (Z.C.), the Department of Neurology, Maoming People's Hospital, Maoming (G.L.), the Department of Neurology, Shanxi Provincial People's Hospital, Taiyuan (Y.S.), the Department of Neurology, Linquan Country People's Hospital, Linquan (Y.R.), the Department of Neurosurgery, Second Affiliated Hospital of Bengbu Medical College, Bengbu (H.Z.), the Department of Neurosurgery, Tongling People's Hospital, Tongling (J.C.), the Department of Neurosurgery, Zhoukou Central Hospital of Henan University, Zhoukou (X.Y.), the Department of Neurology, Zigong Third People's Hospital, Zigong (Li Wang), the Department of Neurology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing (R. Liu, X.L.), the Department of Neurology, Wuhan No. 1 Hospital, Wuhan (W.L.), and the Department of Neurology, Lu'an Hospital of Anhui Medical University, Lu'an (Y. Liu) - all in China; the UPMC Stroke Institute, Department of Neurology and Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh (R.G.N.), and Lehigh Valley Health Network, Allentown (B.B.) - both in Pennsylvania; and the Zeenat Qureshi Stroke Institute and Department of Neurology, University of Missouri, Columbia (A.I.Q.).

Junfeng Su (J)

From the Stroke Center and Department of Neurology, First Affiliated Hospital of the University of Science and Technology of China (USTC), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (C.T., Y.Z., J. Sun, Li Wang, C.Z., T.L., J. Song, R. Li, P.X., Y.Y., G.W., X.L., W.H.), the Department of Neurology, Linyi People's Hospital, Linyi (H.H.), the Emergency Department, Xiangtan Central Hospital, Xiangtan (G.Y.), the Department of Neurology, Nanyang Central Hospital, Nanyang (C.W.), the Department of Neurology, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang (P.Z.), the Department of Neurology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou (W.C.), the Department of Neurology, Ganzhou People's Hospital, Ganzhou (G.Z.), the Department of Neurology, Heze Municipal Hospital, Heze (Y. Li), the Department of Neurology, Suzhou Hospital of Anhui Medical University (Z.M.), and the Department of Neurology and Clinical Research Center of Neurologic Disease, Second Affiliated Hospital of Soochow University (G.X.), Suzhou, the Department of Neurology, First Affiliated Hospital of Anhui University of Science and Technology, First People's Hospital of Huainan, Huainan (C.Y.), the Department of Neurology, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou (J. Su), the Department of Neurology, Yijishan Hospital of Wannan Medical College, Wuhu (Z.Z.), the Department of Neurointervention, Dalian Municipal Central Hospital Affiliated with Dalian Medical University, Dalian (Z.C.), the Department of Neurology, Maoming People's Hospital, Maoming (G.L.), the Department of Neurology, Shanxi Provincial People's Hospital, Taiyuan (Y.S.), the Department of Neurology, Linquan Country People's Hospital, Linquan (Y.R.), the Department of Neurosurgery, Second Affiliated Hospital of Bengbu Medical College, Bengbu (H.Z.), the Department of Neurosurgery, Tongling People's Hospital, Tongling (J.C.), the Department of Neurosurgery, Zhoukou Central Hospital of Henan University, Zhoukou (X.Y.), the Department of Neurology, Zigong Third People's Hospital, Zigong (Li Wang), the Department of Neurology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing (R. Liu, X.L.), the Department of Neurology, Wuhan No. 1 Hospital, Wuhan (W.L.), and the Department of Neurology, Lu'an Hospital of Anhui Medical University, Lu'an (Y. Liu) - all in China; the UPMC Stroke Institute, Department of Neurology and Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh (R.G.N.), and Lehigh Valley Health Network, Allentown (B.B.) - both in Pennsylvania; and the Zeenat Qureshi Stroke Institute and Department of Neurology, University of Missouri, Columbia (A.I.Q.).

Zhiming Zhou (Z)

From the Stroke Center and Department of Neurology, First Affiliated Hospital of the University of Science and Technology of China (USTC), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (C.T., Y.Z., J. Sun, Li Wang, C.Z., T.L., J. Song, R. Li, P.X., Y.Y., G.W., X.L., W.H.), the Department of Neurology, Linyi People's Hospital, Linyi (H.H.), the Emergency Department, Xiangtan Central Hospital, Xiangtan (G.Y.), the Department of Neurology, Nanyang Central Hospital, Nanyang (C.W.), the Department of Neurology, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang (P.Z.), the Department of Neurology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou (W.C.), the Department of Neurology, Ganzhou People's Hospital, Ganzhou (G.Z.), the Department of Neurology, Heze Municipal Hospital, Heze (Y. Li), the Department of Neurology, Suzhou Hospital of Anhui Medical University (Z.M.), and the Department of Neurology and Clinical Research Center of Neurologic Disease, Second Affiliated Hospital of Soochow University (G.X.), Suzhou, the Department of Neurology, First Affiliated Hospital of Anhui University of Science and Technology, First People's Hospital of Huainan, Huainan (C.Y.), the Department of Neurology, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou (J. Su), the Department of Neurology, Yijishan Hospital of Wannan Medical College, Wuhu (Z.Z.), the Department of Neurointervention, Dalian Municipal Central Hospital Affiliated with Dalian Medical University, Dalian (Z.C.), the Department of Neurology, Maoming People's Hospital, Maoming (G.L.), the Department of Neurology, Shanxi Provincial People's Hospital, Taiyuan (Y.S.), the Department of Neurology, Linquan Country People's Hospital, Linquan (Y.R.), the Department of Neurosurgery, Second Affiliated Hospital of Bengbu Medical College, Bengbu (H.Z.), the Department of Neurosurgery, Tongling People's Hospital, Tongling (J.C.), the Department of Neurosurgery, Zhoukou Central Hospital of Henan University, Zhoukou (X.Y.), the Department of Neurology, Zigong Third People's Hospital, Zigong (Li Wang), the Department of Neurology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing (R. Liu, X.L.), the Department of Neurology, Wuhan No. 1 Hospital, Wuhan (W.L.), and the Department of Neurology, Lu'an Hospital of Anhui Medical University, Lu'an (Y. Liu) - all in China; the UPMC Stroke Institute, Department of Neurology and Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh (R.G.N.), and Lehigh Valley Health Network, Allentown (B.B.) - both in Pennsylvania; and the Zeenat Qureshi Stroke Institute and Department of Neurology, University of Missouri, Columbia (A.I.Q.).

Zhongjun Chen (Z)

From the Stroke Center and Department of Neurology, First Affiliated Hospital of the University of Science and Technology of China (USTC), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (C.T., Y.Z., J. Sun, Li Wang, C.Z., T.L., J. Song, R. Li, P.X., Y.Y., G.W., X.L., W.H.), the Department of Neurology, Linyi People's Hospital, Linyi (H.H.), the Emergency Department, Xiangtan Central Hospital, Xiangtan (G.Y.), the Department of Neurology, Nanyang Central Hospital, Nanyang (C.W.), the Department of Neurology, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang (P.Z.), the Department of Neurology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou (W.C.), the Department of Neurology, Ganzhou People's Hospital, Ganzhou (G.Z.), the Department of Neurology, Heze Municipal Hospital, Heze (Y. Li), the Department of Neurology, Suzhou Hospital of Anhui Medical University (Z.M.), and the Department of Neurology and Clinical Research Center of Neurologic Disease, Second Affiliated Hospital of Soochow University (G.X.), Suzhou, the Department of Neurology, First Affiliated Hospital of Anhui University of Science and Technology, First People's Hospital of Huainan, Huainan (C.Y.), the Department of Neurology, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou (J. Su), the Department of Neurology, Yijishan Hospital of Wannan Medical College, Wuhu (Z.Z.), the Department of Neurointervention, Dalian Municipal Central Hospital Affiliated with Dalian Medical University, Dalian (Z.C.), the Department of Neurology, Maoming People's Hospital, Maoming (G.L.), the Department of Neurology, Shanxi Provincial People's Hospital, Taiyuan (Y.S.), the Department of Neurology, Linquan Country People's Hospital, Linquan (Y.R.), the Department of Neurosurgery, Second Affiliated Hospital of Bengbu Medical College, Bengbu (H.Z.), the Department of Neurosurgery, Tongling People's Hospital, Tongling (J.C.), the Department of Neurosurgery, Zhoukou Central Hospital of Henan University, Zhoukou (X.Y.), the Department of Neurology, Zigong Third People's Hospital, Zigong (Li Wang), the Department of Neurology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing (R. Liu, X.L.), the Department of Neurology, Wuhan No. 1 Hospital, Wuhan (W.L.), and the Department of Neurology, Lu'an Hospital of Anhui Medical University, Lu'an (Y. Liu) - all in China; the UPMC Stroke Institute, Department of Neurology and Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh (R.G.N.), and Lehigh Valley Health Network, Allentown (B.B.) - both in Pennsylvania; and the Zeenat Qureshi Stroke Institute and Department of Neurology, University of Missouri, Columbia (A.I.Q.).

Geng Liao (G)

From the Stroke Center and Department of Neurology, First Affiliated Hospital of the University of Science and Technology of China (USTC), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (C.T., Y.Z., J. Sun, Li Wang, C.Z., T.L., J. Song, R. Li, P.X., Y.Y., G.W., X.L., W.H.), the Department of Neurology, Linyi People's Hospital, Linyi (H.H.), the Emergency Department, Xiangtan Central Hospital, Xiangtan (G.Y.), the Department of Neurology, Nanyang Central Hospital, Nanyang (C.W.), the Department of Neurology, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang (P.Z.), the Department of Neurology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou (W.C.), the Department of Neurology, Ganzhou People's Hospital, Ganzhou (G.Z.), the Department of Neurology, Heze Municipal Hospital, Heze (Y. Li), the Department of Neurology, Suzhou Hospital of Anhui Medical University (Z.M.), and the Department of Neurology and Clinical Research Center of Neurologic Disease, Second Affiliated Hospital of Soochow University (G.X.), Suzhou, the Department of Neurology, First Affiliated Hospital of Anhui University of Science and Technology, First People's Hospital of Huainan, Huainan (C.Y.), the Department of Neurology, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou (J. Su), the Department of Neurology, Yijishan Hospital of Wannan Medical College, Wuhu (Z.Z.), the Department of Neurointervention, Dalian Municipal Central Hospital Affiliated with Dalian Medical University, Dalian (Z.C.), the Department of Neurology, Maoming People's Hospital, Maoming (G.L.), the Department of Neurology, Shanxi Provincial People's Hospital, Taiyuan (Y.S.), the Department of Neurology, Linquan Country People's Hospital, Linquan (Y.R.), the Department of Neurosurgery, Second Affiliated Hospital of Bengbu Medical College, Bengbu (H.Z.), the Department of Neurosurgery, Tongling People's Hospital, Tongling (J.C.), the Department of Neurosurgery, Zhoukou Central Hospital of Henan University, Zhoukou (X.Y.), the Department of Neurology, Zigong Third People's Hospital, Zigong (Li Wang), the Department of Neurology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing (R. Liu, X.L.), the Department of Neurology, Wuhan No. 1 Hospital, Wuhan (W.L.), and the Department of Neurology, Lu'an Hospital of Anhui Medical University, Lu'an (Y. Liu) - all in China; the UPMC Stroke Institute, Department of Neurology and Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh (R.G.N.), and Lehigh Valley Health Network, Allentown (B.B.) - both in Pennsylvania; and the Zeenat Qureshi Stroke Institute and Department of Neurology, University of Missouri, Columbia (A.I.Q.).

Yaxuan Sun (Y)

From the Stroke Center and Department of Neurology, First Affiliated Hospital of the University of Science and Technology of China (USTC), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (C.T., Y.Z., J. Sun, Li Wang, C.Z., T.L., J. Song, R. Li, P.X., Y.Y., G.W., X.L., W.H.), the Department of Neurology, Linyi People's Hospital, Linyi (H.H.), the Emergency Department, Xiangtan Central Hospital, Xiangtan (G.Y.), the Department of Neurology, Nanyang Central Hospital, Nanyang (C.W.), the Department of Neurology, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang (P.Z.), the Department of Neurology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou (W.C.), the Department of Neurology, Ganzhou People's Hospital, Ganzhou (G.Z.), the Department of Neurology, Heze Municipal Hospital, Heze (Y. Li), the Department of Neurology, Suzhou Hospital of Anhui Medical University (Z.M.), and the Department of Neurology and Clinical Research Center of Neurologic Disease, Second Affiliated Hospital of Soochow University (G.X.), Suzhou, the Department of Neurology, First Affiliated Hospital of Anhui University of Science and Technology, First People's Hospital of Huainan, Huainan (C.Y.), the Department of Neurology, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou (J. Su), the Department of Neurology, Yijishan Hospital of Wannan Medical College, Wuhu (Z.Z.), the Department of Neurointervention, Dalian Municipal Central Hospital Affiliated with Dalian Medical University, Dalian (Z.C.), the Department of Neurology, Maoming People's Hospital, Maoming (G.L.), the Department of Neurology, Shanxi Provincial People's Hospital, Taiyuan (Y.S.), the Department of Neurology, Linquan Country People's Hospital, Linquan (Y.R.), the Department of Neurosurgery, Second Affiliated Hospital of Bengbu Medical College, Bengbu (H.Z.), the Department of Neurosurgery, Tongling People's Hospital, Tongling (J.C.), the Department of Neurosurgery, Zhoukou Central Hospital of Henan University, Zhoukou (X.Y.), the Department of Neurology, Zigong Third People's Hospital, Zigong (Li Wang), the Department of Neurology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing (R. Liu, X.L.), the Department of Neurology, Wuhan No. 1 Hospital, Wuhan (W.L.), and the Department of Neurology, Lu'an Hospital of Anhui Medical University, Lu'an (Y. Liu) - all in China; the UPMC Stroke Institute, Department of Neurology and Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh (R.G.N.), and Lehigh Valley Health Network, Allentown (B.B.) - both in Pennsylvania; and the Zeenat Qureshi Stroke Institute and Department of Neurology, University of Missouri, Columbia (A.I.Q.).

Youquan Ren (Y)

From the Stroke Center and Department of Neurology, First Affiliated Hospital of the University of Science and Technology of China (USTC), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (C.T., Y.Z., J. Sun, Li Wang, C.Z., T.L., J. Song, R. Li, P.X., Y.Y., G.W., X.L., W.H.), the Department of Neurology, Linyi People's Hospital, Linyi (H.H.), the Emergency Department, Xiangtan Central Hospital, Xiangtan (G.Y.), the Department of Neurology, Nanyang Central Hospital, Nanyang (C.W.), the Department of Neurology, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang (P.Z.), the Department of Neurology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou (W.C.), the Department of Neurology, Ganzhou People's Hospital, Ganzhou (G.Z.), the Department of Neurology, Heze Municipal Hospital, Heze (Y. Li), the Department of Neurology, Suzhou Hospital of Anhui Medical University (Z.M.), and the Department of Neurology and Clinical Research Center of Neurologic Disease, Second Affiliated Hospital of Soochow University (G.X.), Suzhou, the Department of Neurology, First Affiliated Hospital of Anhui University of Science and Technology, First People's Hospital of Huainan, Huainan (C.Y.), the Department of Neurology, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou (J. Su), the Department of Neurology, Yijishan Hospital of Wannan Medical College, Wuhu (Z.Z.), the Department of Neurointervention, Dalian Municipal Central Hospital Affiliated with Dalian Medical University, Dalian (Z.C.), the Department of Neurology, Maoming People's Hospital, Maoming (G.L.), the Department of Neurology, Shanxi Provincial People's Hospital, Taiyuan (Y.S.), the Department of Neurology, Linquan Country People's Hospital, Linquan (Y.R.), the Department of Neurosurgery, Second Affiliated Hospital of Bengbu Medical College, Bengbu (H.Z.), the Department of Neurosurgery, Tongling People's Hospital, Tongling (J.C.), the Department of Neurosurgery, Zhoukou Central Hospital of Henan University, Zhoukou (X.Y.), the Department of Neurology, Zigong Third People's Hospital, Zigong (Li Wang), the Department of Neurology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing (R. Liu, X.L.), the Department of Neurology, Wuhan No. 1 Hospital, Wuhan (W.L.), and the Department of Neurology, Lu'an Hospital of Anhui Medical University, Lu'an (Y. Liu) - all in China; the UPMC Stroke Institute, Department of Neurology and Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh (R.G.N.), and Lehigh Valley Health Network, Allentown (B.B.) - both in Pennsylvania; and the Zeenat Qureshi Stroke Institute and Department of Neurology, University of Missouri, Columbia (A.I.Q.).

Hui Zhang (H)

From the Stroke Center and Department of Neurology, First Affiliated Hospital of the University of Science and Technology of China (USTC), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (C.T., Y.Z., J. Sun, Li Wang, C.Z., T.L., J. Song, R. Li, P.X., Y.Y., G.W., X.L., W.H.), the Department of Neurology, Linyi People's Hospital, Linyi (H.H.), the Emergency Department, Xiangtan Central Hospital, Xiangtan (G.Y.), the Department of Neurology, Nanyang Central Hospital, Nanyang (C.W.), the Department of Neurology, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang (P.Z.), the Department of Neurology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou (W.C.), the Department of Neurology, Ganzhou People's Hospital, Ganzhou (G.Z.), the Department of Neurology, Heze Municipal Hospital, Heze (Y. Li), the Department of Neurology, Suzhou Hospital of Anhui Medical University (Z.M.), and the Department of Neurology and Clinical Research Center of Neurologic Disease, Second Affiliated Hospital of Soochow University (G.X.), Suzhou, the Department of Neurology, First Affiliated Hospital of Anhui University of Science and Technology, First People's Hospital of Huainan, Huainan (C.Y.), the Department of Neurology, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou (J. Su), the Department of Neurology, Yijishan Hospital of Wannan Medical College, Wuhu (Z.Z.), the Department of Neurointervention, Dalian Municipal Central Hospital Affiliated with Dalian Medical University, Dalian (Z.C.), the Department of Neurology, Maoming People's Hospital, Maoming (G.L.), the Department of Neurology, Shanxi Provincial People's Hospital, Taiyuan (Y.S.), the Department of Neurology, Linquan Country People's Hospital, Linquan (Y.R.), the Department of Neurosurgery, Second Affiliated Hospital of Bengbu Medical College, Bengbu (H.Z.), the Department of Neurosurgery, Tongling People's Hospital, Tongling (J.C.), the Department of Neurosurgery, Zhoukou Central Hospital of Henan University, Zhoukou (X.Y.), the Department of Neurology, Zigong Third People's Hospital, Zigong (Li Wang), the Department of Neurology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing (R. Liu, X.L.), the Department of Neurology, Wuhan No. 1 Hospital, Wuhan (W.L.), and the Department of Neurology, Lu'an Hospital of Anhui Medical University, Lu'an (Y. Liu) - all in China; the UPMC Stroke Institute, Department of Neurology and Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh (R.G.N.), and Lehigh Valley Health Network, Allentown (B.B.) - both in Pennsylvania; and the Zeenat Qureshi Stroke Institute and Department of Neurology, University of Missouri, Columbia (A.I.Q.).

Jie Chen (J)

From the Stroke Center and Department of Neurology, First Affiliated Hospital of the University of Science and Technology of China (USTC), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (C.T., Y.Z., J. Sun, Li Wang, C.Z., T.L., J. Song, R. Li, P.X., Y.Y., G.W., X.L., W.H.), the Department of Neurology, Linyi People's Hospital, Linyi (H.H.), the Emergency Department, Xiangtan Central Hospital, Xiangtan (G.Y.), the Department of Neurology, Nanyang Central Hospital, Nanyang (C.W.), the Department of Neurology, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang (P.Z.), the Department of Neurology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou (W.C.), the Department of Neurology, Ganzhou People's Hospital, Ganzhou (G.Z.), the Department of Neurology, Heze Municipal Hospital, Heze (Y. Li), the Department of Neurology, Suzhou Hospital of Anhui Medical University (Z.M.), and the Department of Neurology and Clinical Research Center of Neurologic Disease, Second Affiliated Hospital of Soochow University (G.X.), Suzhou, the Department of Neurology, First Affiliated Hospital of Anhui University of Science and Technology, First People's Hospital of Huainan, Huainan (C.Y.), the Department of Neurology, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou (J. Su), the Department of Neurology, Yijishan Hospital of Wannan Medical College, Wuhu (Z.Z.), the Department of Neurointervention, Dalian Municipal Central Hospital Affiliated with Dalian Medical University, Dalian (Z.C.), the Department of Neurology, Maoming People's Hospital, Maoming (G.L.), the Department of Neurology, Shanxi Provincial People's Hospital, Taiyuan (Y.S.), the Department of Neurology, Linquan Country People's Hospital, Linquan (Y.R.), the Department of Neurosurgery, Second Affiliated Hospital of Bengbu Medical College, Bengbu (H.Z.), the Department of Neurosurgery, Tongling People's Hospital, Tongling (J.C.), the Department of Neurosurgery, Zhoukou Central Hospital of Henan University, Zhoukou (X.Y.), the Department of Neurology, Zigong Third People's Hospital, Zigong (Li Wang), the Department of Neurology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing (R. Liu, X.L.), the Department of Neurology, Wuhan No. 1 Hospital, Wuhan (W.L.), and the Department of Neurology, Lu'an Hospital of Anhui Medical University, Lu'an (Y. Liu) - all in China; the UPMC Stroke Institute, Department of Neurology and Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh (R.G.N.), and Lehigh Valley Health Network, Allentown (B.B.) - both in Pennsylvania; and the Zeenat Qureshi Stroke Institute and Department of Neurology, University of Missouri, Columbia (A.I.Q.).

Xincan Yue (X)

From the Stroke Center and Department of Neurology, First Affiliated Hospital of the University of Science and Technology of China (USTC), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (C.T., Y.Z., J. Sun, Li Wang, C.Z., T.L., J. Song, R. Li, P.X., Y.Y., G.W., X.L., W.H.), the Department of Neurology, Linyi People's Hospital, Linyi (H.H.), the Emergency Department, Xiangtan Central Hospital, Xiangtan (G.Y.), the Department of Neurology, Nanyang Central Hospital, Nanyang (C.W.), the Department of Neurology, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang (P.Z.), the Department of Neurology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou (W.C.), the Department of Neurology, Ganzhou People's Hospital, Ganzhou (G.Z.), the Department of Neurology, Heze Municipal Hospital, Heze (Y. Li), the Department of Neurology, Suzhou Hospital of Anhui Medical University (Z.M.), and the Department of Neurology and Clinical Research Center of Neurologic Disease, Second Affiliated Hospital of Soochow University (G.X.), Suzhou, the Department of Neurology, First Affiliated Hospital of Anhui University of Science and Technology, First People's Hospital of Huainan, Huainan (C.Y.), the Department of Neurology, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou (J. Su), the Department of Neurology, Yijishan Hospital of Wannan Medical College, Wuhu (Z.Z.), the Department of Neurointervention, Dalian Municipal Central Hospital Affiliated with Dalian Medical University, Dalian (Z.C.), the Department of Neurology, Maoming People's Hospital, Maoming (G.L.), the Department of Neurology, Shanxi Provincial People's Hospital, Taiyuan (Y.S.), the Department of Neurology, Linquan Country People's Hospital, Linquan (Y.R.), the Department of Neurosurgery, Second Affiliated Hospital of Bengbu Medical College, Bengbu (H.Z.), the Department of Neurosurgery, Tongling People's Hospital, Tongling (J.C.), the Department of Neurosurgery, Zhoukou Central Hospital of Henan University, Zhoukou (X.Y.), the Department of Neurology, Zigong Third People's Hospital, Zigong (Li Wang), the Department of Neurology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing (R. Liu, X.L.), the Department of Neurology, Wuhan No. 1 Hospital, Wuhan (W.L.), and the Department of Neurology, Lu'an Hospital of Anhui Medical University, Lu'an (Y. Liu) - all in China; the UPMC Stroke Institute, Department of Neurology and Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh (R.G.N.), and Lehigh Valley Health Network, Allentown (B.B.) - both in Pennsylvania; and the Zeenat Qureshi Stroke Institute and Department of Neurology, University of Missouri, Columbia (A.I.Q.).

Guodong Xiao (G)

From the Stroke Center and Department of Neurology, First Affiliated Hospital of the University of Science and Technology of China (USTC), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (C.T., Y.Z., J. Sun, Li Wang, C.Z., T.L., J. Song, R. Li, P.X., Y.Y., G.W., X.L., W.H.), the Department of Neurology, Linyi People's Hospital, Linyi (H.H.), the Emergency Department, Xiangtan Central Hospital, Xiangtan (G.Y.), the Department of Neurology, Nanyang Central Hospital, Nanyang (C.W.), the Department of Neurology, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang (P.Z.), the Department of Neurology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou (W.C.), the Department of Neurology, Ganzhou People's Hospital, Ganzhou (G.Z.), the Department of Neurology, Heze Municipal Hospital, Heze (Y. Li), the Department of Neurology, Suzhou Hospital of Anhui Medical University (Z.M.), and the Department of Neurology and Clinical Research Center of Neurologic Disease, Second Affiliated Hospital of Soochow University (G.X.), Suzhou, the Department of Neurology, First Affiliated Hospital of Anhui University of Science and Technology, First People's Hospital of Huainan, Huainan (C.Y.), the Department of Neurology, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou (J. Su), the Department of Neurology, Yijishan Hospital of Wannan Medical College, Wuhu (Z.Z.), the Department of Neurointervention, Dalian Municipal Central Hospital Affiliated with Dalian Medical University, Dalian (Z.C.), the Department of Neurology, Maoming People's Hospital, Maoming (G.L.), the Department of Neurology, Shanxi Provincial People's Hospital, Taiyuan (Y.S.), the Department of Neurology, Linquan Country People's Hospital, Linquan (Y.R.), the Department of Neurosurgery, Second Affiliated Hospital of Bengbu Medical College, Bengbu (H.Z.), the Department of Neurosurgery, Tongling People's Hospital, Tongling (J.C.), the Department of Neurosurgery, Zhoukou Central Hospital of Henan University, Zhoukou (X.Y.), the Department of Neurology, Zigong Third People's Hospital, Zigong (Li Wang), the Department of Neurology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing (R. Liu, X.L.), the Department of Neurology, Wuhan No. 1 Hospital, Wuhan (W.L.), and the Department of Neurology, Lu'an Hospital of Anhui Medical University, Lu'an (Y. Liu) - all in China; the UPMC Stroke Institute, Department of Neurology and Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh (R.G.N.), and Lehigh Valley Health Network, Allentown (B.B.) - both in Pennsylvania; and the Zeenat Qureshi Stroke Institute and Department of Neurology, University of Missouri, Columbia (A.I.Q.).

Li Wang (L)

From the Stroke Center and Department of Neurology, First Affiliated Hospital of the University of Science and Technology of China (USTC), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (C.T., Y.Z., J. Sun, Li Wang, C.Z., T.L., J. Song, R. Li, P.X., Y.Y., G.W., X.L., W.H.), the Department of Neurology, Linyi People's Hospital, Linyi (H.H.), the Emergency Department, Xiangtan Central Hospital, Xiangtan (G.Y.), the Department of Neurology, Nanyang Central Hospital, Nanyang (C.W.), the Department of Neurology, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang (P.Z.), the Department of Neurology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou (W.C.), the Department of Neurology, Ganzhou People's Hospital, Ganzhou (G.Z.), the Department of Neurology, Heze Municipal Hospital, Heze (Y. Li), the Department of Neurology, Suzhou Hospital of Anhui Medical University (Z.M.), and the Department of Neurology and Clinical Research Center of Neurologic Disease, Second Affiliated Hospital of Soochow University (G.X.), Suzhou, the Department of Neurology, First Affiliated Hospital of Anhui University of Science and Technology, First People's Hospital of Huainan, Huainan (C.Y.), the Department of Neurology, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou (J. Su), the Department of Neurology, Yijishan Hospital of Wannan Medical College, Wuhu (Z.Z.), the Department of Neurointervention, Dalian Municipal Central Hospital Affiliated with Dalian Medical University, Dalian (Z.C.), the Department of Neurology, Maoming People's Hospital, Maoming (G.L.), the Department of Neurology, Shanxi Provincial People's Hospital, Taiyuan (Y.S.), the Department of Neurology, Linquan Country People's Hospital, Linquan (Y.R.), the Department of Neurosurgery, Second Affiliated Hospital of Bengbu Medical College, Bengbu (H.Z.), the Department of Neurosurgery, Tongling People's Hospital, Tongling (J.C.), the Department of Neurosurgery, Zhoukou Central Hospital of Henan University, Zhoukou (X.Y.), the Department of Neurology, Zigong Third People's Hospital, Zigong (Li Wang), the Department of Neurology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing (R. Liu, X.L.), the Department of Neurology, Wuhan No. 1 Hospital, Wuhan (W.L.), and the Department of Neurology, Lu'an Hospital of Anhui Medical University, Lu'an (Y. Liu) - all in China; the UPMC Stroke Institute, Department of Neurology and Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh (R.G.N.), and Lehigh Valley Health Network, Allentown (B.B.) - both in Pennsylvania; and the Zeenat Qureshi Stroke Institute and Department of Neurology, University of Missouri, Columbia (A.I.Q.).

Rui Liu (R)

From the Stroke Center and Department of Neurology, First Affiliated Hospital of the University of Science and Technology of China (USTC), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (C.T., Y.Z., J. Sun, Li Wang, C.Z., T.L., J. Song, R. Li, P.X., Y.Y., G.W., X.L., W.H.), the Department of Neurology, Linyi People's Hospital, Linyi (H.H.), the Emergency Department, Xiangtan Central Hospital, Xiangtan (G.Y.), the Department of Neurology, Nanyang Central Hospital, Nanyang (C.W.), the Department of Neurology, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang (P.Z.), the Department of Neurology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou (W.C.), the Department of Neurology, Ganzhou People's Hospital, Ganzhou (G.Z.), the Department of Neurology, Heze Municipal Hospital, Heze (Y. Li), the Department of Neurology, Suzhou Hospital of Anhui Medical University (Z.M.), and the Department of Neurology and Clinical Research Center of Neurologic Disease, Second Affiliated Hospital of Soochow University (G.X.), Suzhou, the Department of Neurology, First Affiliated Hospital of Anhui University of Science and Technology, First People's Hospital of Huainan, Huainan (C.Y.), the Department of Neurology, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou (J. Su), the Department of Neurology, Yijishan Hospital of Wannan Medical College, Wuhu (Z.Z.), the Department of Neurointervention, Dalian Municipal Central Hospital Affiliated with Dalian Medical University, Dalian (Z.C.), the Department of Neurology, Maoming People's Hospital, Maoming (G.L.), the Department of Neurology, Shanxi Provincial People's Hospital, Taiyuan (Y.S.), the Department of Neurology, Linquan Country People's Hospital, Linquan (Y.R.), the Department of Neurosurgery, Second Affiliated Hospital of Bengbu Medical College, Bengbu (H.Z.), the Department of Neurosurgery, Tongling People's Hospital, Tongling (J.C.), the Department of Neurosurgery, Zhoukou Central Hospital of Henan University, Zhoukou (X.Y.), the Department of Neurology, Zigong Third People's Hospital, Zigong (Li Wang), the Department of Neurology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing (R. Liu, X.L.), the Department of Neurology, Wuhan No. 1 Hospital, Wuhan (W.L.), and the Department of Neurology, Lu'an Hospital of Anhui Medical University, Lu'an (Y. Liu) - all in China; the UPMC Stroke Institute, Department of Neurology and Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh (R.G.N.), and Lehigh Valley Health Network, Allentown (B.B.) - both in Pennsylvania; and the Zeenat Qureshi Stroke Institute and Department of Neurology, University of Missouri, Columbia (A.I.Q.).

Wenhua Liu (W)

From the Stroke Center and Department of Neurology, First Affiliated Hospital of the University of Science and Technology of China (USTC), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (C.T., Y.Z., J. Sun, Li Wang, C.Z., T.L., J. Song, R. Li, P.X., Y.Y., G.W., X.L., W.H.), the Department of Neurology, Linyi People's Hospital, Linyi (H.H.), the Emergency Department, Xiangtan Central Hospital, Xiangtan (G.Y.), the Department of Neurology, Nanyang Central Hospital, Nanyang (C.W.), the Department of Neurology, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang (P.Z.), the Department of Neurology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou (W.C.), the Department of Neurology, Ganzhou People's Hospital, Ganzhou (G.Z.), the Department of Neurology, Heze Municipal Hospital, Heze (Y. Li), the Department of Neurology, Suzhou Hospital of Anhui Medical University (Z.M.), and the Department of Neurology and Clinical Research Center of Neurologic Disease, Second Affiliated Hospital of Soochow University (G.X.), Suzhou, the Department of Neurology, First Affiliated Hospital of Anhui University of Science and Technology, First People's Hospital of Huainan, Huainan (C.Y.), the Department of Neurology, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou (J. Su), the Department of Neurology, Yijishan Hospital of Wannan Medical College, Wuhu (Z.Z.), the Department of Neurointervention, Dalian Municipal Central Hospital Affiliated with Dalian Medical University, Dalian (Z.C.), the Department of Neurology, Maoming People's Hospital, Maoming (G.L.), the Department of Neurology, Shanxi Provincial People's Hospital, Taiyuan (Y.S.), the Department of Neurology, Linquan Country People's Hospital, Linquan (Y.R.), the Department of Neurosurgery, Second Affiliated Hospital of Bengbu Medical College, Bengbu (H.Z.), the Department of Neurosurgery, Tongling People's Hospital, Tongling (J.C.), the Department of Neurosurgery, Zhoukou Central Hospital of Henan University, Zhoukou (X.Y.), the Department of Neurology, Zigong Third People's Hospital, Zigong (Li Wang), the Department of Neurology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing (R. Liu, X.L.), the Department of Neurology, Wuhan No. 1 Hospital, Wuhan (W.L.), and the Department of Neurology, Lu'an Hospital of Anhui Medical University, Lu'an (Y. Liu) - all in China; the UPMC Stroke Institute, Department of Neurology and Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh (R.G.N.), and Lehigh Valley Health Network, Allentown (B.B.) - both in Pennsylvania; and the Zeenat Qureshi Stroke Institute and Department of Neurology, University of Missouri, Columbia (A.I.Q.).

Yong Liu (Y)

From the Stroke Center and Department of Neurology, First Affiliated Hospital of the University of Science and Technology of China (USTC), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (C.T., Y.Z., J. Sun, Li Wang, C.Z., T.L., J. Song, R. Li, P.X., Y.Y., G.W., X.L., W.H.), the Department of Neurology, Linyi People's Hospital, Linyi (H.H.), the Emergency Department, Xiangtan Central Hospital, Xiangtan (G.Y.), the Department of Neurology, Nanyang Central Hospital, Nanyang (C.W.), the Department of Neurology, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang (P.Z.), the Department of Neurology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou (W.C.), the Department of Neurology, Ganzhou People's Hospital, Ganzhou (G.Z.), the Department of Neurology, Heze Municipal Hospital, Heze (Y. Li), the Department of Neurology, Suzhou Hospital of Anhui Medical University (Z.M.), and the Department of Neurology and Clinical Research Center of Neurologic Disease, Second Affiliated Hospital of Soochow University (G.X.), Suzhou, the Department of Neurology, First Affiliated Hospital of Anhui University of Science and Technology, First People's Hospital of Huainan, Huainan (C.Y.), the Department of Neurology, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou (J. Su), the Department of Neurology, Yijishan Hospital of Wannan Medical College, Wuhu (Z.Z.), the Department of Neurointervention, Dalian Municipal Central Hospital Affiliated with Dalian Medical University, Dalian (Z.C.), the Department of Neurology, Maoming People's Hospital, Maoming (G.L.), the Department of Neurology, Shanxi Provincial People's Hospital, Taiyuan (Y.S.), the Department of Neurology, Linquan Country People's Hospital, Linquan (Y.R.), the Department of Neurosurgery, Second Affiliated Hospital of Bengbu Medical College, Bengbu (H.Z.), the Department of Neurosurgery, Tongling People's Hospital, Tongling (J.C.), the Department of Neurosurgery, Zhoukou Central Hospital of Henan University, Zhoukou (X.Y.), the Department of Neurology, Zigong Third People's Hospital, Zigong (Li Wang), the Department of Neurology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing (R. Liu, X.L.), the Department of Neurology, Wuhan No. 1 Hospital, Wuhan (W.L.), and the Department of Neurology, Lu'an Hospital of Anhui Medical University, Lu'an (Y. Liu) - all in China; the UPMC Stroke Institute, Department of Neurology and Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh (R.G.N.), and Lehigh Valley Health Network, Allentown (B.B.) - both in Pennsylvania; and the Zeenat Qureshi Stroke Institute and Department of Neurology, University of Missouri, Columbia (A.I.Q.).

Li Wang (L)

From the Stroke Center and Department of Neurology, First Affiliated Hospital of the University of Science and Technology of China (USTC), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (C.T., Y.Z., J. Sun, Li Wang, C.Z., T.L., J. Song, R. Li, P.X., Y.Y., G.W., X.L., W.H.), the Department of Neurology, Linyi People's Hospital, Linyi (H.H.), the Emergency Department, Xiangtan Central Hospital, Xiangtan (G.Y.), the Department of Neurology, Nanyang Central Hospital, Nanyang (C.W.), the Department of Neurology, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang (P.Z.), the Department of Neurology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou (W.C.), the Department of Neurology, Ganzhou People's Hospital, Ganzhou (G.Z.), the Department of Neurology, Heze Municipal Hospital, Heze (Y. Li), the Department of Neurology, Suzhou Hospital of Anhui Medical University (Z.M.), and the Department of Neurology and Clinical Research Center of Neurologic Disease, Second Affiliated Hospital of Soochow University (G.X.), Suzhou, the Department of Neurology, First Affiliated Hospital of Anhui University of Science and Technology, First People's Hospital of Huainan, Huainan (C.Y.), the Department of Neurology, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou (J. Su), the Department of Neurology, Yijishan Hospital of Wannan Medical College, Wuhu (Z.Z.), the Department of Neurointervention, Dalian Municipal Central Hospital Affiliated with Dalian Medical University, Dalian (Z.C.), the Department of Neurology, Maoming People's Hospital, Maoming (G.L.), the Department of Neurology, Shanxi Provincial People's Hospital, Taiyuan (Y.S.), the Department of Neurology, Linquan Country People's Hospital, Linquan (Y.R.), the Department of Neurosurgery, Second Affiliated Hospital of Bengbu Medical College, Bengbu (H.Z.), the Department of Neurosurgery, Tongling People's Hospital, Tongling (J.C.), the Department of Neurosurgery, Zhoukou Central Hospital of Henan University, Zhoukou (X.Y.), the Department of Neurology, Zigong Third People's Hospital, Zigong (Li Wang), the Department of Neurology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing (R. Liu, X.L.), the Department of Neurology, Wuhan No. 1 Hospital, Wuhan (W.L.), and the Department of Neurology, Lu'an Hospital of Anhui Medical University, Lu'an (Y. Liu) - all in China; the UPMC Stroke Institute, Department of Neurology and Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh (R.G.N.), and Lehigh Valley Health Network, Allentown (B.B.) - both in Pennsylvania; and the Zeenat Qureshi Stroke Institute and Department of Neurology, University of Missouri, Columbia (A.I.Q.).

Chao Zhang (C)

From the Stroke Center and Department of Neurology, First Affiliated Hospital of the University of Science and Technology of China (USTC), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (C.T., Y.Z., J. Sun, Li Wang, C.Z., T.L., J. Song, R. Li, P.X., Y.Y., G.W., X.L., W.H.), the Department of Neurology, Linyi People's Hospital, Linyi (H.H.), the Emergency Department, Xiangtan Central Hospital, Xiangtan (G.Y.), the Department of Neurology, Nanyang Central Hospital, Nanyang (C.W.), the Department of Neurology, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang (P.Z.), the Department of Neurology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou (W.C.), the Department of Neurology, Ganzhou People's Hospital, Ganzhou (G.Z.), the Department of Neurology, Heze Municipal Hospital, Heze (Y. Li), the Department of Neurology, Suzhou Hospital of Anhui Medical University (Z.M.), and the Department of Neurology and Clinical Research Center of Neurologic Disease, Second Affiliated Hospital of Soochow University (G.X.), Suzhou, the Department of Neurology, First Affiliated Hospital of Anhui University of Science and Technology, First People's Hospital of Huainan, Huainan (C.Y.), the Department of Neurology, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou (J. Su), the Department of Neurology, Yijishan Hospital of Wannan Medical College, Wuhu (Z.Z.), the Department of Neurointervention, Dalian Municipal Central Hospital Affiliated with Dalian Medical University, Dalian (Z.C.), the Department of Neurology, Maoming People's Hospital, Maoming (G.L.), the Department of Neurology, Shanxi Provincial People's Hospital, Taiyuan (Y.S.), the Department of Neurology, Linquan Country People's Hospital, Linquan (Y.R.), the Department of Neurosurgery, Second Affiliated Hospital of Bengbu Medical College, Bengbu (H.Z.), the Department of Neurosurgery, Tongling People's Hospital, Tongling (J.C.), the Department of Neurosurgery, Zhoukou Central Hospital of Henan University, Zhoukou (X.Y.), the Department of Neurology, Zigong Third People's Hospital, Zigong (Li Wang), the Department of Neurology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing (R. Liu, X.L.), the Department of Neurology, Wuhan No. 1 Hospital, Wuhan (W.L.), and the Department of Neurology, Lu'an Hospital of Anhui Medical University, Lu'an (Y. Liu) - all in China; the UPMC Stroke Institute, Department of Neurology and Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh (R.G.N.), and Lehigh Valley Health Network, Allentown (B.B.) - both in Pennsylvania; and the Zeenat Qureshi Stroke Institute and Department of Neurology, University of Missouri, Columbia (A.I.Q.).

Tianlong Liu (T)

From the Stroke Center and Department of Neurology, First Affiliated Hospital of the University of Science and Technology of China (USTC), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (C.T., Y.Z., J. Sun, Li Wang, C.Z., T.L., J. Song, R. Li, P.X., Y.Y., G.W., X.L., W.H.), the Department of Neurology, Linyi People's Hospital, Linyi (H.H.), the Emergency Department, Xiangtan Central Hospital, Xiangtan (G.Y.), the Department of Neurology, Nanyang Central Hospital, Nanyang (C.W.), the Department of Neurology, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang (P.Z.), the Department of Neurology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou (W.C.), the Department of Neurology, Ganzhou People's Hospital, Ganzhou (G.Z.), the Department of Neurology, Heze Municipal Hospital, Heze (Y. Li), the Department of Neurology, Suzhou Hospital of Anhui Medical University (Z.M.), and the Department of Neurology and Clinical Research Center of Neurologic Disease, Second Affiliated Hospital of Soochow University (G.X.), Suzhou, the Department of Neurology, First Affiliated Hospital of Anhui University of Science and Technology, First People's Hospital of Huainan, Huainan (C.Y.), the Department of Neurology, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou (J. Su), the Department of Neurology, Yijishan Hospital of Wannan Medical College, Wuhu (Z.Z.), the Department of Neurointervention, Dalian Municipal Central Hospital Affiliated with Dalian Medical University, Dalian (Z.C.), the Department of Neurology, Maoming People's Hospital, Maoming (G.L.), the Department of Neurology, Shanxi Provincial People's Hospital, Taiyuan (Y.S.), the Department of Neurology, Linquan Country People's Hospital, Linquan (Y.R.), the Department of Neurosurgery, Second Affiliated Hospital of Bengbu Medical College, Bengbu (H.Z.), the Department of Neurosurgery, Tongling People's Hospital, Tongling (J.C.), the Department of Neurosurgery, Zhoukou Central Hospital of Henan University, Zhoukou (X.Y.), the Department of Neurology, Zigong Third People's Hospital, Zigong (Li Wang), the Department of Neurology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing (R. Liu, X.L.), the Department of Neurology, Wuhan No. 1 Hospital, Wuhan (W.L.), and the Department of Neurology, Lu'an Hospital of Anhui Medical University, Lu'an (Y. Liu) - all in China; the UPMC Stroke Institute, Department of Neurology and Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh (R.G.N.), and Lehigh Valley Health Network, Allentown (B.B.) - both in Pennsylvania; and the Zeenat Qureshi Stroke Institute and Department of Neurology, University of Missouri, Columbia (A.I.Q.).

Jianlong Song (J)

From the Stroke Center and Department of Neurology, First Affiliated Hospital of the University of Science and Technology of China (USTC), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (C.T., Y.Z., J. Sun, Li Wang, C.Z., T.L., J. Song, R. Li, P.X., Y.Y., G.W., X.L., W.H.), the Department of Neurology, Linyi People's Hospital, Linyi (H.H.), the Emergency Department, Xiangtan Central Hospital, Xiangtan (G.Y.), the Department of Neurology, Nanyang Central Hospital, Nanyang (C.W.), the Department of Neurology, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang (P.Z.), the Department of Neurology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou (W.C.), the Department of Neurology, Ganzhou People's Hospital, Ganzhou (G.Z.), the Department of Neurology, Heze Municipal Hospital, Heze (Y. Li), the Department of Neurology, Suzhou Hospital of Anhui Medical University (Z.M.), and the Department of Neurology and Clinical Research Center of Neurologic Disease, Second Affiliated Hospital of Soochow University (G.X.), Suzhou, the Department of Neurology, First Affiliated Hospital of Anhui University of Science and Technology, First People's Hospital of Huainan, Huainan (C.Y.), the Department of Neurology, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou (J. Su), the Department of Neurology, Yijishan Hospital of Wannan Medical College, Wuhu (Z.Z.), the Department of Neurointervention, Dalian Municipal Central Hospital Affiliated with Dalian Medical University, Dalian (Z.C.), the Department of Neurology, Maoming People's Hospital, Maoming (G.L.), the Department of Neurology, Shanxi Provincial People's Hospital, Taiyuan (Y.S.), the Department of Neurology, Linquan Country People's Hospital, Linquan (Y.R.), the Department of Neurosurgery, Second Affiliated Hospital of Bengbu Medical College, Bengbu (H.Z.), the Department of Neurosurgery, Tongling People's Hospital, Tongling (J.C.), the Department of Neurosurgery, Zhoukou Central Hospital of Henan University, Zhoukou (X.Y.), the Department of Neurology, Zigong Third People's Hospital, Zigong (Li Wang), the Department of Neurology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing (R. Liu, X.L.), the Department of Neurology, Wuhan No. 1 Hospital, Wuhan (W.L.), and the Department of Neurology, Lu'an Hospital of Anhui Medical University, Lu'an (Y. Liu) - all in China; the UPMC Stroke Institute, Department of Neurology and Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh (R.G.N.), and Lehigh Valley Health Network, Allentown (B.B.) - both in Pennsylvania; and the Zeenat Qureshi Stroke Institute and Department of Neurology, University of Missouri, Columbia (A.I.Q.).

Rui Li (R)

From the Stroke Center and Department of Neurology, First Affiliated Hospital of the University of Science and Technology of China (USTC), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (C.T., Y.Z., J. Sun, Li Wang, C.Z., T.L., J. Song, R. Li, P.X., Y.Y., G.W., X.L., W.H.), the Department of Neurology, Linyi People's Hospital, Linyi (H.H.), the Emergency Department, Xiangtan Central Hospital, Xiangtan (G.Y.), the Department of Neurology, Nanyang Central Hospital, Nanyang (C.W.), the Department of Neurology, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang (P.Z.), the Department of Neurology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou (W.C.), the Department of Neurology, Ganzhou People's Hospital, Ganzhou (G.Z.), the Department of Neurology, Heze Municipal Hospital, Heze (Y. Li), the Department of Neurology, Suzhou Hospital of Anhui Medical University (Z.M.), and the Department of Neurology and Clinical Research Center of Neurologic Disease, Second Affiliated Hospital of Soochow University (G.X.), Suzhou, the Department of Neurology, First Affiliated Hospital of Anhui University of Science and Technology, First People's Hospital of Huainan, Huainan (C.Y.), the Department of Neurology, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou (J. Su), the Department of Neurology, Yijishan Hospital of Wannan Medical College, Wuhu (Z.Z.), the Department of Neurointervention, Dalian Municipal Central Hospital Affiliated with Dalian Medical University, Dalian (Z.C.), the Department of Neurology, Maoming People's Hospital, Maoming (G.L.), the Department of Neurology, Shanxi Provincial People's Hospital, Taiyuan (Y.S.), the Department of Neurology, Linquan Country People's Hospital, Linquan (Y.R.), the Department of Neurosurgery, Second Affiliated Hospital of Bengbu Medical College, Bengbu (H.Z.), the Department of Neurosurgery, Tongling People's Hospital, Tongling (J.C.), the Department of Neurosurgery, Zhoukou Central Hospital of Henan University, Zhoukou (X.Y.), the Department of Neurology, Zigong Third People's Hospital, Zigong (Li Wang), the Department of Neurology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing (R. Liu, X.L.), the Department of Neurology, Wuhan No. 1 Hospital, Wuhan (W.L.), and the Department of Neurology, Lu'an Hospital of Anhui Medical University, Lu'an (Y. Liu) - all in China; the UPMC Stroke Institute, Department of Neurology and Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh (R.G.N.), and Lehigh Valley Health Network, Allentown (B.B.) - both in Pennsylvania; and the Zeenat Qureshi Stroke Institute and Department of Neurology, University of Missouri, Columbia (A.I.Q.).

Pengfei Xu (P)

From the Stroke Center and Department of Neurology, First Affiliated Hospital of the University of Science and Technology of China (USTC), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (C.T., Y.Z., J. Sun, Li Wang, C.Z., T.L., J. Song, R. Li, P.X., Y.Y., G.W., X.L., W.H.), the Department of Neurology, Linyi People's Hospital, Linyi (H.H.), the Emergency Department, Xiangtan Central Hospital, Xiangtan (G.Y.), the Department of Neurology, Nanyang Central Hospital, Nanyang (C.W.), the Department of Neurology, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang (P.Z.), the Department of Neurology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou (W.C.), the Department of Neurology, Ganzhou People's Hospital, Ganzhou (G.Z.), the Department of Neurology, Heze Municipal Hospital, Heze (Y. Li), the Department of Neurology, Suzhou Hospital of Anhui Medical University (Z.M.), and the Department of Neurology and Clinical Research Center of Neurologic Disease, Second Affiliated Hospital of Soochow University (G.X.), Suzhou, the Department of Neurology, First Affiliated Hospital of Anhui University of Science and Technology, First People's Hospital of Huainan, Huainan (C.Y.), the Department of Neurology, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou (J. Su), the Department of Neurology, Yijishan Hospital of Wannan Medical College, Wuhu (Z.Z.), the Department of Neurointervention, Dalian Municipal Central Hospital Affiliated with Dalian Medical University, Dalian (Z.C.), the Department of Neurology, Maoming People's Hospital, Maoming (G.L.), the Department of Neurology, Shanxi Provincial People's Hospital, Taiyuan (Y.S.), the Department of Neurology, Linquan Country People's Hospital, Linquan (Y.R.), the Department of Neurosurgery, Second Affiliated Hospital of Bengbu Medical College, Bengbu (H.Z.), the Department of Neurosurgery, Tongling People's Hospital, Tongling (J.C.), the Department of Neurosurgery, Zhoukou Central Hospital of Henan University, Zhoukou (X.Y.), the Department of Neurology, Zigong Third People's Hospital, Zigong (Li Wang), the Department of Neurology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing (R. Liu, X.L.), the Department of Neurology, Wuhan No. 1 Hospital, Wuhan (W.L.), and the Department of Neurology, Lu'an Hospital of Anhui Medical University, Lu'an (Y. Liu) - all in China; the UPMC Stroke Institute, Department of Neurology and Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh (R.G.N.), and Lehigh Valley Health Network, Allentown (B.B.) - both in Pennsylvania; and the Zeenat Qureshi Stroke Institute and Department of Neurology, University of Missouri, Columbia (A.I.Q.).

Yamei Yin (Y)

From the Stroke Center and Department of Neurology, First Affiliated Hospital of the University of Science and Technology of China (USTC), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (C.T., Y.Z., J. Sun, Li Wang, C.Z., T.L., J. Song, R. Li, P.X., Y.Y., G.W., X.L., W.H.), the Department of Neurology, Linyi People's Hospital, Linyi (H.H.), the Emergency Department, Xiangtan Central Hospital, Xiangtan (G.Y.), the Department of Neurology, Nanyang Central Hospital, Nanyang (C.W.), the Department of Neurology, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang (P.Z.), the Department of Neurology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou (W.C.), the Department of Neurology, Ganzhou People's Hospital, Ganzhou (G.Z.), the Department of Neurology, Heze Municipal Hospital, Heze (Y. Li), the Department of Neurology, Suzhou Hospital of Anhui Medical University (Z.M.), and the Department of Neurology and Clinical Research Center of Neurologic Disease, Second Affiliated Hospital of Soochow University (G.X.), Suzhou, the Department of Neurology, First Affiliated Hospital of Anhui University of Science and Technology, First People's Hospital of Huainan, Huainan (C.Y.), the Department of Neurology, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou (J. Su), the Department of Neurology, Yijishan Hospital of Wannan Medical College, Wuhu (Z.Z.), the Department of Neurointervention, Dalian Municipal Central Hospital Affiliated with Dalian Medical University, Dalian (Z.C.), the Department of Neurology, Maoming People's Hospital, Maoming (G.L.), the Department of Neurology, Shanxi Provincial People's Hospital, Taiyuan (Y.S.), the Department of Neurology, Linquan Country People's Hospital, Linquan (Y.R.), the Department of Neurosurgery, Second Affiliated Hospital of Bengbu Medical College, Bengbu (H.Z.), the Department of Neurosurgery, Tongling People's Hospital, Tongling (J.C.), the Department of Neurosurgery, Zhoukou Central Hospital of Henan University, Zhoukou (X.Y.), the Department of Neurology, Zigong Third People's Hospital, Zigong (Li Wang), the Department of Neurology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing (R. Liu, X.L.), the Department of Neurology, Wuhan No. 1 Hospital, Wuhan (W.L.), and the Department of Neurology, Lu'an Hospital of Anhui Medical University, Lu'an (Y. Liu) - all in China; the UPMC Stroke Institute, Department of Neurology and Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh (R.G.N.), and Lehigh Valley Health Network, Allentown (B.B.) - both in Pennsylvania; and the Zeenat Qureshi Stroke Institute and Department of Neurology, University of Missouri, Columbia (A.I.Q.).

Guoping Wang (G)

From the Stroke Center and Department of Neurology, First Affiliated Hospital of the University of Science and Technology of China (USTC), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (C.T., Y.Z., J. Sun, Li Wang, C.Z., T.L., J. Song, R. Li, P.X., Y.Y., G.W., X.L., W.H.), the Department of Neurology, Linyi People's Hospital, Linyi (H.H.), the Emergency Department, Xiangtan Central Hospital, Xiangtan (G.Y.), the Department of Neurology, Nanyang Central Hospital, Nanyang (C.W.), the Department of Neurology, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang (P.Z.), the Department of Neurology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou (W.C.), the Department of Neurology, Ganzhou People's Hospital, Ganzhou (G.Z.), the Department of Neurology, Heze Municipal Hospital, Heze (Y. Li), the Department of Neurology, Suzhou Hospital of Anhui Medical University (Z.M.), and the Department of Neurology and Clinical Research Center of Neurologic Disease, Second Affiliated Hospital of Soochow University (G.X.), Suzhou, the Department of Neurology, First Affiliated Hospital of Anhui University of Science and Technology, First People's Hospital of Huainan, Huainan (C.Y.), the Department of Neurology, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou (J. Su), the Department of Neurology, Yijishan Hospital of Wannan Medical College, Wuhu (Z.Z.), the Department of Neurointervention, Dalian Municipal Central Hospital Affiliated with Dalian Medical University, Dalian (Z.C.), the Department of Neurology, Maoming People's Hospital, Maoming (G.L.), the Department of Neurology, Shanxi Provincial People's Hospital, Taiyuan (Y.S.), the Department of Neurology, Linquan Country People's Hospital, Linquan (Y.R.), the Department of Neurosurgery, Second Affiliated Hospital of Bengbu Medical College, Bengbu (H.Z.), the Department of Neurosurgery, Tongling People's Hospital, Tongling (J.C.), the Department of Neurosurgery, Zhoukou Central Hospital of Henan University, Zhoukou (X.Y.), the Department of Neurology, Zigong Third People's Hospital, Zigong (Li Wang), the Department of Neurology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing (R. Liu, X.L.), the Department of Neurology, Wuhan No. 1 Hospital, Wuhan (W.L.), and the Department of Neurology, Lu'an Hospital of Anhui Medical University, Lu'an (Y. Liu) - all in China; the UPMC Stroke Institute, Department of Neurology and Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh (R.G.N.), and Lehigh Valley Health Network, Allentown (B.B.) - both in Pennsylvania; and the Zeenat Qureshi Stroke Institute and Department of Neurology, University of Missouri, Columbia (A.I.Q.).

Blaise Baxter (B)

From the Stroke Center and Department of Neurology, First Affiliated Hospital of the University of Science and Technology of China (USTC), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (C.T., Y.Z., J. Sun, Li Wang, C.Z., T.L., J. Song, R. Li, P.X., Y.Y., G.W., X.L., W.H.), the Department of Neurology, Linyi People's Hospital, Linyi (H.H.), the Emergency Department, Xiangtan Central Hospital, Xiangtan (G.Y.), the Department of Neurology, Nanyang Central Hospital, Nanyang (C.W.), the Department of Neurology, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang (P.Z.), the Department of Neurology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou (W.C.), the Department of Neurology, Ganzhou People's Hospital, Ganzhou (G.Z.), the Department of Neurology, Heze Municipal Hospital, Heze (Y. Li), the Department of Neurology, Suzhou Hospital of Anhui Medical University (Z.M.), and the Department of Neurology and Clinical Research Center of Neurologic Disease, Second Affiliated Hospital of Soochow University (G.X.), Suzhou, the Department of Neurology, First Affiliated Hospital of Anhui University of Science and Technology, First People's Hospital of Huainan, Huainan (C.Y.), the Department of Neurology, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou (J. Su), the Department of Neurology, Yijishan Hospital of Wannan Medical College, Wuhu (Z.Z.), the Department of Neurointervention, Dalian Municipal Central Hospital Affiliated with Dalian Medical University, Dalian (Z.C.), the Department of Neurology, Maoming People's Hospital, Maoming (G.L.), the Department of Neurology, Shanxi Provincial People's Hospital, Taiyuan (Y.S.), the Department of Neurology, Linquan Country People's Hospital, Linquan (Y.R.), the Department of Neurosurgery, Second Affiliated Hospital of Bengbu Medical College, Bengbu (H.Z.), the Department of Neurosurgery, Tongling People's Hospital, Tongling (J.C.), the Department of Neurosurgery, Zhoukou Central Hospital of Henan University, Zhoukou (X.Y.), the Department of Neurology, Zigong Third People's Hospital, Zigong (Li Wang), the Department of Neurology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing (R. Liu, X.L.), the Department of Neurology, Wuhan No. 1 Hospital, Wuhan (W.L.), and the Department of Neurology, Lu'an Hospital of Anhui Medical University, Lu'an (Y. Liu) - all in China; the UPMC Stroke Institute, Department of Neurology and Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh (R.G.N.), and Lehigh Valley Health Network, Allentown (B.B.) - both in Pennsylvania; and the Zeenat Qureshi Stroke Institute and Department of Neurology, University of Missouri, Columbia (A.I.Q.).

Adnan I Qureshi (AI)

From the Stroke Center and Department of Neurology, First Affiliated Hospital of the University of Science and Technology of China (USTC), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (C.T., Y.Z., J. Sun, Li Wang, C.Z., T.L., J. Song, R. Li, P.X., Y.Y., G.W., X.L., W.H.), the Department of Neurology, Linyi People's Hospital, Linyi (H.H.), the Emergency Department, Xiangtan Central Hospital, Xiangtan (G.Y.), the Department of Neurology, Nanyang Central Hospital, Nanyang (C.W.), the Department of Neurology, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang (P.Z.), the Department of Neurology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou (W.C.), the Department of Neurology, Ganzhou People's Hospital, Ganzhou (G.Z.), the Department of Neurology, Heze Municipal Hospital, Heze (Y. Li), the Department of Neurology, Suzhou Hospital of Anhui Medical University (Z.M.), and the Department of Neurology and Clinical Research Center of Neurologic Disease, Second Affiliated Hospital of Soochow University (G.X.), Suzhou, the Department of Neurology, First Affiliated Hospital of Anhui University of Science and Technology, First People's Hospital of Huainan, Huainan (C.Y.), the Department of Neurology, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou (J. Su), the Department of Neurology, Yijishan Hospital of Wannan Medical College, Wuhu (Z.Z.), the Department of Neurointervention, Dalian Municipal Central Hospital Affiliated with Dalian Medical University, Dalian (Z.C.), the Department of Neurology, Maoming People's Hospital, Maoming (G.L.), the Department of Neurology, Shanxi Provincial People's Hospital, Taiyuan (Y.S.), the Department of Neurology, Linquan Country People's Hospital, Linquan (Y.R.), the Department of Neurosurgery, Second Affiliated Hospital of Bengbu Medical College, Bengbu (H.Z.), the Department of Neurosurgery, Tongling People's Hospital, Tongling (J.C.), the Department of Neurosurgery, Zhoukou Central Hospital of Henan University, Zhoukou (X.Y.), the Department of Neurology, Zigong Third People's Hospital, Zigong (Li Wang), the Department of Neurology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing (R. Liu, X.L.), the Department of Neurology, Wuhan No. 1 Hospital, Wuhan (W.L.), and the Department of Neurology, Lu'an Hospital of Anhui Medical University, Lu'an (Y. Liu) - all in China; the UPMC Stroke Institute, Department of Neurology and Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh (R.G.N.), and Lehigh Valley Health Network, Allentown (B.B.) - both in Pennsylvania; and the Zeenat Qureshi Stroke Institute and Department of Neurology, University of Missouri, Columbia (A.I.Q.).

Xinfeng Liu (X)

From the Stroke Center and Department of Neurology, First Affiliated Hospital of the University of Science and Technology of China (USTC), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (C.T., Y.Z., J. Sun, Li Wang, C.Z., T.L., J. Song, R. Li, P.X., Y.Y., G.W., X.L., W.H.), the Department of Neurology, Linyi People's Hospital, Linyi (H.H.), the Emergency Department, Xiangtan Central Hospital, Xiangtan (G.Y.), the Department of Neurology, Nanyang Central Hospital, Nanyang (C.W.), the Department of Neurology, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang (P.Z.), the Department of Neurology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou (W.C.), the Department of Neurology, Ganzhou People's Hospital, Ganzhou (G.Z.), the Department of Neurology, Heze Municipal Hospital, Heze (Y. Li), the Department of Neurology, Suzhou Hospital of Anhui Medical University (Z.M.), and the Department of Neurology and Clinical Research Center of Neurologic Disease, Second Affiliated Hospital of Soochow University (G.X.), Suzhou, the Department of Neurology, First Affiliated Hospital of Anhui University of Science and Technology, First People's Hospital of Huainan, Huainan (C.Y.), the Department of Neurology, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou (J. Su), the Department of Neurology, Yijishan Hospital of Wannan Medical College, Wuhu (Z.Z.), the Department of Neurointervention, Dalian Municipal Central Hospital Affiliated with Dalian Medical University, Dalian (Z.C.), the Department of Neurology, Maoming People's Hospital, Maoming (G.L.), the Department of Neurology, Shanxi Provincial People's Hospital, Taiyuan (Y.S.), the Department of Neurology, Linquan Country People's Hospital, Linquan (Y.R.), the Department of Neurosurgery, Second Affiliated Hospital of Bengbu Medical College, Bengbu (H.Z.), the Department of Neurosurgery, Tongling People's Hospital, Tongling (J.C.), the Department of Neurosurgery, Zhoukou Central Hospital of Henan University, Zhoukou (X.Y.), the Department of Neurology, Zigong Third People's Hospital, Zigong (Li Wang), the Department of Neurology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing (R. Liu, X.L.), the Department of Neurology, Wuhan No. 1 Hospital, Wuhan (W.L.), and the Department of Neurology, Lu'an Hospital of Anhui Medical University, Lu'an (Y. Liu) - all in China; the UPMC Stroke Institute, Department of Neurology and Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh (R.G.N.), and Lehigh Valley Health Network, Allentown (B.B.) - both in Pennsylvania; and the Zeenat Qureshi Stroke Institute and Department of Neurology, University of Missouri, Columbia (A.I.Q.).

Wei Hu (W)

From the Stroke Center and Department of Neurology, First Affiliated Hospital of the University of Science and Technology of China (USTC), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei (C.T., Y.Z., J. Sun, Li Wang, C.Z., T.L., J. Song, R. Li, P.X., Y.Y., G.W., X.L., W.H.), the Department of Neurology, Linyi People's Hospital, Linyi (H.H.), the Emergency Department, Xiangtan Central Hospital, Xiangtan (G.Y.), the Department of Neurology, Nanyang Central Hospital, Nanyang (C.W.), the Department of Neurology, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang (P.Z.), the Department of Neurology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou (W.C.), the Department of Neurology, Ganzhou People's Hospital, Ganzhou (G.Z.), the Department of Neurology, Heze Municipal Hospital, Heze (Y. Li), the Department of Neurology, Suzhou Hospital of Anhui Medical University (Z.M.), and the Department of Neurology and Clinical Research Center of Neurologic Disease, Second Affiliated Hospital of Soochow University (G.X.), Suzhou, the Department of Neurology, First Affiliated Hospital of Anhui University of Science and Technology, First People's Hospital of Huainan, Huainan (C.Y.), the Department of Neurology, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou (J. Su), the Department of Neurology, Yijishan Hospital of Wannan Medical College, Wuhu (Z.Z.), the Department of Neurointervention, Dalian Municipal Central Hospital Affiliated with Dalian Medical University, Dalian (Z.C.), the Department of Neurology, Maoming People's Hospital, Maoming (G.L.), the Department of Neurology, Shanxi Provincial People's Hospital, Taiyuan (Y.S.), the Department of Neurology, Linquan Country People's Hospital, Linquan (Y.R.), the Department of Neurosurgery, Second Affiliated Hospital of Bengbu Medical College, Bengbu (H.Z.), the Department of Neurosurgery, Tongling People's Hospital, Tongling (J.C.), the Department of Neurosurgery, Zhoukou Central Hospital of Henan University, Zhoukou (X.Y.), the Department of Neurology, Zigong Third People's Hospital, Zigong (Li Wang), the Department of Neurology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing (R. Liu, X.L.), the Department of Neurology, Wuhan No. 1 Hospital, Wuhan (W.L.), and the Department of Neurology, Lu'an Hospital of Anhui Medical University, Lu'an (Y. Liu) - all in China; the UPMC Stroke Institute, Department of Neurology and Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh (R.G.N.), and Lehigh Valley Health Network, Allentown (B.B.) - both in Pennsylvania; and the Zeenat Qureshi Stroke Institute and Department of Neurology, University of Missouri, Columbia (A.I.Q.).

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