Kinetin induces microtubular breakdown, cell cycle arrest and programmed cell death in tobacco BY-2 cells.
Callose
Cell cycle arrest
Kinetin
Microtubules
Programmed cell death
Tobacco BY-2
Journal
Protoplasma
ISSN: 1615-6102
Titre abrégé: Protoplasma
Pays: Austria
ID NLM: 9806853
Informations de publication
Date de publication:
May 2023
May 2023
Historique:
received:
05
06
2022
accepted:
04
10
2022
medline:
26
4
2023
pubmed:
15
10
2022
entrez:
14
10
2022
Statut:
ppublish
Résumé
Plant cells can undergo regulated cell death in response to exogenous factors (often in a stress context), but also as regular element of development (often regulated by phytohormones). The cellular aspects of these death responses differ, which implies that the early signalling must be different. We use cytokinin-induced programmed cell death as paradigm to get insight into the role of the cytoskeleton for the regulation of developmentally induced cell death, using tobacco BY-2 cells as experimental model. We show that this PCD in response to kinetin correlates with an arrest of the cell cycle, a deregulation of DNA replication, a loss of plasma membrane integrity, a subsequent permeabilisation of the nuclear envelope, an increase of cytosolic calcium correlated with calcium depletion in the culture medium, an increase of callose deposition and the loss of microtubule and actin integrity. We discuss these findings in the context of a working model, where kinetin, mediated by calcium, causes the breakdown of the cytoskeleton, which, either by release of executing proteins or by mitotic catastrophe, will result in PCD.
Identifiants
pubmed: 36239807
doi: 10.1007/s00709-022-01814-6
pii: 10.1007/s00709-022-01814-6
pmc: PMC10125952
doi:
Substances chimiques
Kinetin
P39Y9652YJ
Calcium
SY7Q814VUP
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
787-806Subventions
Organisme : University of Łódź
ID : 1409
Informations de copyright
© 2022. The Author(s).
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