Immunopeptidomics-based design of mRNA vaccine formulations against Listeria monocytogenes.
Animals
Bacterial Proteins
/ genetics
Bacterial Vaccines
/ genetics
CD8-Positive T-Lymphocytes
Humans
Immunodominant Epitopes
Liposomes
Listeria
/ genetics
Listeria monocytogenes
/ genetics
Listeriosis
/ prevention & control
Membrane Proteins
Mice
Nanoparticles
Vaccines, Attenuated
Vaccines, Synthetic
/ genetics
mRNA Vaccines
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
14 10 2022
14 10 2022
Historique:
received:
15
07
2022
accepted:
29
09
2022
entrez:
14
10
2022
pubmed:
15
10
2022
medline:
19
10
2022
Statut:
epublish
Résumé
Listeria monocytogenes is a foodborne intracellular bacterial pathogen leading to human listeriosis. Despite a high mortality rate and increasing antibiotic resistance no clinically approved vaccine against Listeria is available. Attenuated Listeria strains offer protection and are tested as antitumor vaccine vectors, but would benefit from a better knowledge on immunodominant vector antigens. To identify novel antigens, we screen for Listeria peptides presented on the surface of infected human cell lines by mass spectrometry-based immunopeptidomics. In between more than 15,000 human self-peptides, we detect 68 Listeria immunopeptides from 42 different bacterial proteins, including several known antigens. Peptides presented on different cell lines are often derived from the same bacterial surface proteins, classifying these antigens as potential vaccine candidates. Encoding these highly presented antigens in lipid nanoparticle mRNA vaccine formulations results in specific CD8
Identifiants
pubmed: 36241641
doi: 10.1038/s41467-022-33721-y
pii: 10.1038/s41467-022-33721-y
pmc: PMC9562072
doi:
Substances chimiques
Bacterial Proteins
0
Bacterial Vaccines
0
Immunodominant Epitopes
0
Lipid Nanoparticles
0
Liposomes
0
Membrane Proteins
0
Vaccines, Attenuated
0
Vaccines, Synthetic
0
mRNA Vaccines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
6075Informations de copyright
© 2022. The Author(s).
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