In vivo fluorescence imaging: success in preclinical imaging paves the way for clinical applications.
Antibody conjugates
Fluorescence imaging
ICG
Near-infrared
Targeted imaging
Journal
Journal of nanobiotechnology
ISSN: 1477-3155
Titre abrégé: J Nanobiotechnology
Pays: England
ID NLM: 101152208
Informations de publication
Date de publication:
15 Oct 2022
15 Oct 2022
Historique:
received:
25
06
2022
accepted:
23
09
2022
entrez:
15
10
2022
pubmed:
16
10
2022
medline:
19
10
2022
Statut:
epublish
Résumé
Advances in diagnostic imaging have provided unprecedented opportunities to detect diseases at early stages and with high reliability. Diagnostic imaging is also crucial to monitoring the progress or remission of disease and thus is often the central basis of therapeutic decision-making. Currently, several diagnostic imaging modalities (computed tomography, magnetic resonance imaging, and positron emission tomography, among others) are routinely used in clinics and present their own advantages and limitations. In vivo near-infrared (NIR) fluorescence imaging has recently emerged as an attractive imaging modality combining low cost, high sensitivity, and relative safety. As a preclinical tool, it can be used to investigate disease mechanisms and for testing novel diagnostics and therapeutics prior to their clinical use. However, the limited depth of tissue penetration is a major challenge to efficient clinical use. Therefore, the current clinical use of fluorescence imaging is limited to a few applications such as image-guided surgery on tumors and retinal angiography, using FDA-approved dyes. Progress in fluorophore development and NIR imaging technologies holds promise to extend their clinical application to oncology, cardiovascular diseases, plastic surgery, and brain imaging, among others. Nanotechnology is expected to revolutionize diagnostic in vivo fluorescence imaging through targeted delivery of NIR fluorescent probes using antibody conjugation. In this review, we discuss the latest advances in in vivo fluorescence imaging technologies, NIR fluorescent probes, and current and future clinical applications.
Identifiants
pubmed: 36243718
doi: 10.1186/s12951-022-01648-7
pii: 10.1186/s12951-022-01648-7
pmc: PMC9571426
doi:
Substances chimiques
Fluorescent Dyes
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
450Subventions
Organisme : Australian Research Council
ID : DE200100985
Organisme : National Heart Foundation Future Leader Fellowship
ID : 101932
Organisme : National Health and Medical Research Council Investigator L3 Fellowship
ID : GNT1174098
Informations de copyright
© 2022. The Author(s).
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