Underlying mechanisms in the relationship between stress and alcohol consumption in regular and risky drinkers (MESA): methods and design of a randomized laboratory study.
AUD
Acute stress
Ad-libitum taste-test
Risky alcohol consumption
TSST
Journal
BMC psychology
ISSN: 2050-7283
Titre abrégé: BMC Psychol
Pays: England
ID NLM: 101627676
Informations de publication
Date de publication:
15 Oct 2022
15 Oct 2022
Historique:
received:
08
06
2022
accepted:
05
10
2022
entrez:
15
10
2022
pubmed:
16
10
2022
medline:
19
10
2022
Statut:
epublish
Résumé
Excessive alcohol consumption and alcohol use disorders (AUD) are among the leading preventable causes of premature morbidity and mortality and are considered a major public health concern. In order to reduce the individual and societal burden of excessive alcohol use, it is crucial to identify high-risk individuals at earlier stages and to provide effective interventions to prevent further progression. Stressful experiences are important risk factors for excessive alcohol consumption and AUDs. However, the underlying biological and psychological mechanisms are still poorly understood. The project "Underlying mechanisms in the relationship between stress and alcohol consumption in regular and risky drinkers (MESA)" is a randomized controlled study that started in December 2018 and is conducted in a laboratory setting, which aims to identify moderators and mediators of the relationship between acute stress and alcohol consumption among regular and risky drinkers. Regular and risky drinkers are randomly assigned to a stress induction or a control condition. Several processes that may mediate (emotional distress, endocrine and autonomic stress reactivity, impulsivity, inhibitory control, motivational sensitization) or moderate (trait impulsivity, childhood maltreatment, basal HPA-axis activity) the relation between stress and alcohol consumption are investigated. As primary dependent variable, the motivation to consume alcohol following psychosocial stress is measured. The results of this study could help to provide valuable targets for future research on tailored interventions to prevent stress-related alcohol consumption.
Sections du résumé
BACKGROUND
BACKGROUND
Excessive alcohol consumption and alcohol use disorders (AUD) are among the leading preventable causes of premature morbidity and mortality and are considered a major public health concern. In order to reduce the individual and societal burden of excessive alcohol use, it is crucial to identify high-risk individuals at earlier stages and to provide effective interventions to prevent further progression. Stressful experiences are important risk factors for excessive alcohol consumption and AUDs. However, the underlying biological and psychological mechanisms are still poorly understood.
METHODS
METHODS
The project "Underlying mechanisms in the relationship between stress and alcohol consumption in regular and risky drinkers (MESA)" is a randomized controlled study that started in December 2018 and is conducted in a laboratory setting, which aims to identify moderators and mediators of the relationship between acute stress and alcohol consumption among regular and risky drinkers. Regular and risky drinkers are randomly assigned to a stress induction or a control condition. Several processes that may mediate (emotional distress, endocrine and autonomic stress reactivity, impulsivity, inhibitory control, motivational sensitization) or moderate (trait impulsivity, childhood maltreatment, basal HPA-axis activity) the relation between stress and alcohol consumption are investigated. As primary dependent variable, the motivation to consume alcohol following psychosocial stress is measured.
DISCUSSION
CONCLUSIONS
The results of this study could help to provide valuable targets for future research on tailored interventions to prevent stress-related alcohol consumption.
Identifiants
pubmed: 36243742
doi: 10.1186/s40359-022-00942-1
pii: 10.1186/s40359-022-00942-1
pmc: PMC9568994
doi:
Substances chimiques
Ethanol
3K9958V90M
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
233Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : TR 1489/1-1
Informations de copyright
© 2022. The Author(s).
Références
Addiction. 2007 Mar;102(3):399-405
pubmed: 17298647
BMC Fam Pract. 2015 Jul 29;16:90
pubmed: 26219430
J Behav Ther Exp Psychiatry. 2011 Jun;42(2):225-32
pubmed: 21315886
Alcohol Alcohol. 2007 Nov-Dec;42(6):560-6
pubmed: 17766316
Annu Rev Med. 2011;62:431-45
pubmed: 20707675
J Exp Psychol Gen. 2016 Dec;145(12):1635-1653
pubmed: 27736135
Trends Neurosci. 2014 Apr;37(4):219-27
pubmed: 24636458
Behav Ther. 2011 Dec;42(4):676-88
pubmed: 22035996
Am J Drug Alcohol Abuse. 2008;34(3):339-45
pubmed: 18428076
Curr Psychiatry Rep. 2019 Feb 7;21(2):10
pubmed: 30729322
Addict Biol. 2019 Sep;24(5):1096-1108
pubmed: 30091823
Curr Opin Neurobiol. 2013 Aug;23(4):649-54
pubmed: 23764204
Lancet. 2019 Aug 31;394(10200):781-792
pubmed: 31478502
Int J Behav Med. 1997;4(1):92-100
pubmed: 16250744
Alcohol Clin Exp Res. 2015 Sep;39(9):1712-26
pubmed: 26331879
Clin Chem. 2008 Nov;54(11):1759-69
pubmed: 18757583
Nat Neurosci. 2005 Nov;8(11):1442-4
pubmed: 16251985
Arch Gen Psychiatry. 2006 Dec;63(12):1386-95
pubmed: 17146013
Int J Psychophysiol. 2013 Sep;89(3):342-8
pubmed: 23623953
Depress Anxiety. 2013 Feb;30(2):174-83
pubmed: 23280888
Psychopharmacology (Berl). 2020 Sep;237(9):2709-2724
pubmed: 32500211
Psychoneuroendocrinology. 2015 Sep;59:123-33
pubmed: 26072152
Neurosci Biobehav Rev. 2019 Dec;107:686-695
pubmed: 31560923
Drug Alcohol Depend. 2014 Jan 1;134:296-303
pubmed: 24262650
Psychoneuroendocrinology. 2003 Oct;28(7):916-31
pubmed: 12892658
Exp Clin Psychopharmacol. 2017 Dec;25(6):521-533
pubmed: 29251982
Addict Behav. 2008 Jan;33(1):196-200
pubmed: 17720324
Psychol Bull. 2009 Jul;135(4):589-607
pubmed: 19586163
Psychoneuroendocrinology. 2009 Aug;34(7):1075-86
pubmed: 19307062
Brain Res Mol Brain Res. 1997 Dec 1;52(1):78-89
pubmed: 9450680
Sci Rep. 2018 Mar 7;8(1):4104
pubmed: 29515146
Exp Clin Psychopharmacol. 2013 Feb;21(1):8-16
pubmed: 23181512
Behav Res Methods. 2019 Feb;51(1):40-60
pubmed: 30022459
Psychosom Med. 1992 Nov-Dec;54(6):648-57
pubmed: 1454958
Psychiatry Res. 2014 Mar 30;215(3):675-82
pubmed: 24434041
J Trauma Stress. 2009 Feb;22(1):65-8
pubmed: 19145642
Clin Psychol Rev. 2000 Mar;20(2):149-71
pubmed: 10721495
Neuropharmacology. 2017 Aug 1;122:136-147
pubmed: 28159647
Addict Biol. 2009 Jan;14(1):22-31
pubmed: 18855805
Psychopharmacology (Berl). 2005 Dec;183(3):350-7
pubmed: 16235080
Am J Drug Alcohol Abuse. 2020;46(1):88-97
pubmed: 31430201
Pharmacol Ther. 2012 Jun;134(3):287-97
pubmed: 22387232
Mol Psychiatry. 2009 Nov;14(11):1051-66
pubmed: 18427559
Addiction. 1996 Dec;91 Suppl:S37-49
pubmed: 8997780
PLoS One. 2018 Apr 18;13(4):e0195063
pubmed: 29668736
Psychopharmacology (Berl). 2016 Apr;233(7):1227-34
pubmed: 26815361
Psychosom Med. 2013 Nov-Dec;75(9):832-40
pubmed: 24184845
J Pers. 2004 Apr;72(2):271-324
pubmed: 15016066
Drug Alcohol Depend. 2011 Jan 1;113(1):55-61
pubmed: 20724083
Psychoneuroendocrinology. 2016 Nov;73:16-23
pubmed: 27448524
Nebr Symp Motiv. 2004;50:19-55
pubmed: 15160637
Drug Alcohol Depend. 2020 Dec 1;217:108246
pubmed: 32932160
Psychosom Med. 2012 May;74(4):418-31
pubmed: 22582339
Trends Neurosci. 2010 Jan;33(1):10-6
pubmed: 19819033
J Gerontol Nurs. 1999 Dec;25(12):10-1
pubmed: 10711108
Pharmacol Biochem Behav. 2007 Feb;86(2):263-83
pubmed: 17116324
J Stud Alcohol Drugs. 2012 Jul;73(4):559-69
pubmed: 22630794
Psychol Addict Behav. 2019 Aug;33(5):431-441
pubmed: 31294578
Psychoneuroendocrinology. 2018 Apr;90:194-210
pubmed: 29370954
J Stud Alcohol. 1999 Jan;60(1):90-8
pubmed: 10096313
Psychoneuroendocrinology. 2009 Feb;34(2):163-171
pubmed: 19095358
Curr Opin Psychiatry. 2007 Jul;20(4):359-64
pubmed: 17551351
Addict Behav. 2015 Aug;47:11-6
pubmed: 25841089
Alcohol Clin Exp Res. 2014 Jul;38(7):2048-55
pubmed: 24961735
Front Psychiatry. 2014 Jul 17;5:83
pubmed: 25101007
Brain Behav Immun. 2012 Oct;26(7):1019-29
pubmed: 22366690
Drug Alcohol Depend. 2011 Jul 1;116(1-3):132-6
pubmed: 21288663
Addiction. 2005 Feb;100(2):227-34
pubmed: 15679752
Biol Psychiatry. 2008 Jan 15;63(2):146-51
pubmed: 17597588
Epidemiology. 1992 Mar;3(2):143-55
pubmed: 1576220
Behav Res Methods. 2018 Feb;50(1):236-249
pubmed: 28289888
Exp Clin Psychopharmacol. 2009 Oct;17(5):312-9
pubmed: 19803630
Psychol Bull. 2004 May;130(3):355-91
pubmed: 15122924
J Clin Child Adolesc Psychol. 2009 Nov;38(6):899-908
pubmed: 20183672
Addict Behav. 2004 Jul;29(5):879-92
pubmed: 15219332
Alcohol Alcohol. 2014 Mar-Apr;49(2):173-81
pubmed: 24243684
Exp Clin Psychopharmacol. 2012 Apr;20(2):118-28
pubmed: 22182418
Drug Alcohol Depend. 2012 Aug 1;124(3):189-90
pubmed: 22386685
Alcohol Res. 2012;34(4):391-400
pubmed: 23584105
Alcohol Clin Exp Res. 2015 Dec;39(12):2471-9
pubmed: 26613633
Harv Rev Psychiatry. 1997 Jan-Feb;4(5):231-44
pubmed: 9385000
Spat Vis. 1997;10(4):433-6
pubmed: 9176952
J Clin Psychiatry. 2012 May;73(5):e588-93
pubmed: 22697205
Neuropsychobiology. 1993;28(1-2):76-81
pubmed: 8255414
Neuropsychology. 2019 Sep;33(6):808-821
pubmed: 31448948
Depress Anxiety. 2003;18(2):76-82
pubmed: 12964174
Neuropharmacology. 2017 Aug 1;122:115-126
pubmed: 28431971
Psychiatriki. 2015 Apr-Jun;26(2):131-40
pubmed: 26197102
Prog Neuropsychopharmacol Biol Psychiatry. 2003 Jun;27(4):563-79
pubmed: 12787841
Addict Biol. 2018 Jan;23(1):281-290
pubmed: 28105726
Psychoneuroendocrinology. 2009 May;34(4):469-85
pubmed: 19155141
Drug Alcohol Depend. 2012 Feb 1;121(1-2):148-51
pubmed: 21955365
Psychosom Med. 2003 May-Jun;65(3):450-60
pubmed: 12764219
Addiction. 2010 May;105(5):817-43
pubmed: 20331573
J Abnorm Psychol. 2002 May;111(2):225-36
pubmed: 12003445
Drug Alcohol Depend. 2008 Sep 1;97(1-2):1-20
pubmed: 18479844
Alcohol Res Health. 2008;31(2):119-36
pubmed: 23584814
J Stud Alcohol. 2005 Nov;66(6):795-805
pubmed: 16459941
Neurobiol Stress. 2019 Feb 08;10:100149
pubmed: 30949562
Alcohol Res. 2012;34(4):468-83
pubmed: 23584113
Alcohol Res. 2012;34(4):432-40
pubmed: 23584109
Psychopharmacology (Berl). 2018 May;235(5):1487-1496
pubmed: 29497782
Psychopharmacology (Berl). 2016 Mar;233(5):917-24
pubmed: 26680342