Accommodation in allogeneic and xenogeneic organ transplantation: Prevalence, impact, and implications for monitoring and for therapeutics.
ABO-incompatible transplant
Accommodation
Allograft
Antibody
Antibody-mediated rejection
B cell
Complement
Complement activation
Endothelial cell activation
Heparan sulfate
Organ transplant
Rejection
Xenograft
Journal
Human immunology
ISSN: 1879-1166
Titre abrégé: Hum Immunol
Pays: United States
ID NLM: 8010936
Informations de publication
Date de publication:
Jan 2023
Jan 2023
Historique:
received:
22
06
2022
accepted:
01
08
2022
pubmed:
17
10
2022
medline:
5
1
2023
entrez:
16
10
2022
Statut:
ppublish
Résumé
Accommodation refers to acquired resistance of organs or tissues to immune or inflammatory reactions that might otherwise cause severe injury or rejection. As first observed in ABO-incompatible kidney transplants and heterotopic cardiac xenografts, accommodation was identified when organ transplants continued to function despite the presence of anti-graft antibodies and/or other reactants in the blood of recipients. Recent evidence suggests many and perhaps most organ transplants have accommodation, as most recipients mount B cell responses specific for the graft. Wide interest in the impact of graft-specific antibodies on the outcomes of transplants prompts questions about which mechanisms confer protection against such antibodies, how accommodation might be detected and whether and how rejection could be superimposed on accommodation. Xenotransplantation offers a unique opportunity to address these questions because immune responses to xenografts are easily detected and the pathogenic impact of immune responses is so severe. Xenotransplantation also provides a compelling need to apply these and other insights to decrease the intensity and toxicity of immunosuppression that otherwise could limit clinical application.
Identifiants
pubmed: 36244871
pii: S0198-8859(22)00150-1
doi: 10.1016/j.humimm.2022.08.001
pmc: PMC10339678
mid: NIHMS1894710
pii:
doi:
Substances chimiques
Antibodies
0
ABO Blood-Group System
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
5-17Subventions
Organisme : NIAID NIH HHS
ID : R01 AI122369
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI151588
Pays : United States
Organisme : NIH HHS
ID : R01 OD023138
Pays : United States
Organisme : NIAID NIH HHS
ID : R56 AI123262
Pays : United States
Informations de copyright
Copyright © 2022 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Références
Hum Immunol. 2023 Jan;84(1):27-33
pubmed: 36333165
ILAR J. 2018 Dec 31;59(3):286-308
pubmed: 30541147
Nat Med. 2004 Nov;10(11):1227-33
pubmed: 15502841
Transplantation. 2000 Dec 27;70(12):1667-74
pubmed: 11152095
Cancer Res. 1992 Jan 1;52(1):89-94
pubmed: 1530769
Glycobiology. 1998 May;8(5):433-43
pubmed: 9597541
Front Cardiovasc Med. 2022 Mar 31;9:866751
pubmed: 35433860
Circulation. 2000 Apr 18;101(15):1867-73
pubmed: 10769290
Dev Biol. 1990 Jun;139(2):338-48
pubmed: 2140104
Am J Transplant. 2013 Jul;13(7):1713-23
pubmed: 23750851
Adv Exp Med Biol. 2015;865:123-40
pubmed: 26306447
Am J Kidney Dis. 2008 Apr;51(4):678-90
pubmed: 18371544
J Exp Med. 1995 Jan 1;181(1):21-31
pubmed: 7807003
Kidney Int. 2015 Sep;88(3):439-41
pubmed: 26323070
Transplantation. 2004 Sep 15;78(5):635-40
pubmed: 15371661
Adv Chronic Kidney Dis. 2016 Sep;23(5):317-325
pubmed: 27742387
Transplantation. 2001 Mar 15;71(5):652-8
pubmed: 11292296
Am J Transplant. 2012 May;12(5):1157-67
pubmed: 22429309
Biochem Biophys Res Commun. 2003 Feb 14;301(3):751-7
pubmed: 12565844
J Immunol. 2004 May 1;172(9):5143-8
pubmed: 15100249
Nat Med. 1997 Feb;3(2):196-204
pubmed: 9018239
Circ Res. 2002 Dec 13;91(12):1135-41
pubmed: 12480814
Immunol Today. 1993 Oct;14(10):500-5
pubmed: 8274190
Transplantation. 2009 Dec 15;88(11):1233-6
pubmed: 19996920
Am J Transplant. 2011 Oct;11(10):2007-8
pubmed: 21827619
Am J Transplant. 2020 Jun;20 Suppl 4:23-32
pubmed: 32538534
ACS Chem Neurosci. 2019 May 15;10(5):2186-2194
pubmed: 30916550
Am J Pathol. 1998 Mar;152(3):829-39
pubmed: 9502425
Transplantation. 2012 Mar 27;93(6):603-9
pubmed: 22290268
J Leukoc Biol. 2007 Aug;82(2):282-5
pubmed: 17495051
Lancet. 1966 Sep 24;2(7465):662-5
pubmed: 4162350
Curr Opin Genet Dev. 2020 Oct;64:60-65
pubmed: 32619817
Transplantation. 2021 Nov 1;105(11):e181-e190
pubmed: 33901113
Hum Immunol. 2019 Jun;80(6):385-392
pubmed: 30836129
J Immunol. 1991 Jan 15;146(2):730-4
pubmed: 1987283
J Exp Med. 1974 Sep 1;140(3):619-30
pubmed: 4607241
Cell Immunol. 2007 Jul;248(1):12-7
pubmed: 17920574
Transplantation. 1990 May;49(5):1000-1
pubmed: 2336684
J Clin Invest. 1995 Nov;96(5):2404-12
pubmed: 7593628
Nephrol Dial Transplant. 2018 Aug 1;33(8):1472-1480
pubmed: 29660004
Immunol Today. 1990 Dec;11(12):450-6; discussion 456-7
pubmed: 2073317
Transplant Proc. 1993 Feb;25(1 Pt 1):382
pubmed: 8438344
J Immunol. 1995 Aug 15;155(4):2203-10
pubmed: 7636268
Glycobiology. 1996 Jul;6(5):499-506
pubmed: 8877370
Transplantation. 1995 Jan 15;59(1):1-6
pubmed: 7839407
Transplantation. 2015 Feb;99(2):400-4
pubmed: 25050471
Circulation. 2020 Oct 6;142(14):1389-1398
pubmed: 33017208
Immunol Rev. 2019 Nov;292(1):180-193
pubmed: 31609002
Am J Transplant. 2010 Mar;10(3):582-9
pubmed: 20121740
Mol Immunol. 1999 Sep-Oct;36(13-14):929-39
pubmed: 10698347
J Clin Invest. 1998 Apr 15;101(8):1745-56
pubmed: 9541506
Am J Transplant. 2008 Jan;8(1):32-40
pubmed: 17973967
FASEB J. 2005 Feb;19(2):211-21
pubmed: 15677344
Am J Transplant. 2012 Mar;12(3):763-71
pubmed: 22070772
Transfus Med. 1991 Sep;1(3):177-82
pubmed: 9259845
Transplantation. 1991 Dec;52(6):937-47
pubmed: 1750079
J Clin Invest. 1997 Sep 1;100(5):1150-8
pubmed: 9276732
Adv Drug Deliv Rev. 2021 Jan;168:229-245
pubmed: 32275950
J Immunol. 1965 Sep;95(3):559-66
pubmed: 5841048
Hum Immunol. 2009 Aug;70(8):589-94
pubmed: 19375470
Hum Immunol. 2019 Jun;80(6):363-377
pubmed: 30980861
Immunity. 2001 Apr;14(4):437-46
pubmed: 11336689
Am J Transplant. 2017 Jun;17(6):1574-1584
pubmed: 27977905
J Immunol. 2004 Mar 15;172(6):3869-75
pubmed: 15004194
J Clin Invest. 1972 Mar;51(3):583-9
pubmed: 4622104
J Exp Med. 1995 Dec 1;182(6):1807-14
pubmed: 7500026
J Am Soc Nephrol. 2002 Sep;13(9):2417-9
pubmed: 12191987
Circ Res. 2016 Apr 29;118(9):1348-62
pubmed: 27126646
J Immunol. 2005 Jun 1;174(11):7302-9
pubmed: 15905577
Immunol Today. 1996 Aug;17(8):373-8
pubmed: 8783498
J Immunol. 1986 Jul 1;137(1):263-70
pubmed: 3711667
Nat Biomed Eng. 2020 Apr;4(4):463-475
pubmed: 31685999
Biophys J. 2021 Aug 3;120(15):3180-3191
pubmed: 34197803
Xenotransplantation. 2018 May;25(3):e12418
pubmed: 29913044
J Immunol. 1998 Aug 15;161(4):2044-51
pubmed: 9712078
J Immunol. 2013 Feb 1;190(3):875-9
pubmed: 23335803
Transplantation. 1991 Dec;52(6):1037-43
pubmed: 1750066
Springer Semin Immunopathol. 2003 Sep;25(2):95-117
pubmed: 12955462
Clin Transpl. 2013;:407-12
pubmed: 25095536
Am J Pathol. 1995 May;146(5):1260-72
pubmed: 7747818
Transplantation. 1996 Aug 15;62(3):303-10
pubmed: 8779674
FASEB J. 2002 Jun;16(8):849-56
pubmed: 12039867
J Heart Lung Transplant. 2020 Aug;39(8):751-757
pubmed: 32527674
Hum Immunol. 2007 Aug;68(8):645-51
pubmed: 17678718
J Clin Invest. 2014 Nov;124(11):4857-66
pubmed: 25271628
Am J Kidney Dis. 1992 Oct;20(4):414-21
pubmed: 1415213
Nat Med. 2000 May;6(5):497-8
pubmed: 10802695
JCI Insight. 2021 Sep 8;6(17):
pubmed: 34283811
J Clin Invest. 2017 Jun 30;127(7):2492-2504
pubmed: 28604384
Transplantation. 2015 Jun;99(6):1156-64
pubmed: 25629531
Nat Med. 1995 May;1(5):423-7
pubmed: 7585088
J Immunol. 2000 Apr 1;164(7):3764-73
pubmed: 10725736
Front Immunol. 2017 Jan 27;8:4
pubmed: 28191005
Immunol Today. 1997 Oct;18(10):483-6
pubmed: 9357140
J Immunol. 2004 Jan 1;172(1):20-4
pubmed: 14688304
Transplantation. 2001 Jan 27;71(2):313-9
pubmed: 11213079
Am J Transplant. 2003 Aug;3(8):952-60
pubmed: 12859529
Circ Res. 2006 Mar 31;98(6):793-800
pubmed: 16514066
Clin Exp Immunol. 1991 Oct;86 Suppl 1:31-5
pubmed: 1718641
Am J Transplant. 2004 Mar;4(3):438-43
pubmed: 14961999
J Heart Lung Transplant. 2020 Aug;39(8):758-760
pubmed: 32650983
Transplant Proc. 1989 Feb;21(1 Pt 1):783-5
pubmed: 2650269
Transplantation. 1997 Nov 15;64(9):1255-61
pubmed: 9371665
Pediatr Transplant. 2011 Nov;15(7):686-90
pubmed: 22004543
Am J Transplant. 2017 Dec;17(12):3210-3218
pubmed: 28805293
Transplant Proc. 1987 Dec;19(6):4553-7
pubmed: 3321617
Front Immunol. 2021 Feb 17;12:634544
pubmed: 33679786
Transplantation. 1997 Feb 27;63(4):594-603
pubmed: 9047157
Biochem J. 1985 Oct 1;231(1):205-8
pubmed: 4062885
Nat Commun. 2016 Apr 05;7:11138
pubmed: 27045379
Am J Transplant. 2007 Apr;7(4):908-13
pubmed: 17391133
World J Surg. 1997 Nov-Dec;21(9):924-31
pubmed: 9361506
Transplantation. 1996 Jan 15;61(1):161-4
pubmed: 8560559
J Thorac Cardiovasc Surg. 2023 Feb;165(2):e69-e81
pubmed: 34579956
Curr Opin Organ Transplant. 2017 Oct;22(5):470-476
pubmed: 28682798
Transplant Proc. 1987 Dec;19(6):4528-37
pubmed: 2447692
Transplantation. 2004 Nov 27;78(10):1471-8
pubmed: 15599311
Transplantation. 2001 Aug 15;72(3):509-15
pubmed: 11502984
Circ Res. 2008 Apr 11;102(7):823-30
pubmed: 18292602
Immunol Rev. 1994 Oct;141:127-49
pubmed: 7868152
Transplantation. 2006 Jun 27;81(12):1686-94
pubmed: 16794535
J Cell Physiol. 1998 Jun;175(3):255-67
pubmed: 9572470
Blood. 1999 Sep 1;94(5):1673-82
pubmed: 10477692
Am J Pathol. 1992 May;140(5):1157-66
pubmed: 1580328
J Exp Med. 1990 Apr 1;171(4):1363-8
pubmed: 2139104
Transpl Immunol. 1997 Sep;5(3):212-8
pubmed: 9402688
Am J Pathol. 2004 Mar;164(3):1073-80
pubmed: 14982860
Mol Immunol. 1999 Sep-Oct;36(13-14):965-71
pubmed: 10698351
Transplantation. 2013 Jan 15;95(1):19-47
pubmed: 23238534
Transplant Proc. 1997 Feb-Mar;29(1-2):884-5
pubmed: 9123568
Kidney Int. 2019 Jul;96(1):202-213
pubmed: 31029504
J Exp Med. 1989 Sep 1;170(3):991-6
pubmed: 2504879
J Clin Invest. 1989 Dec;84(6):1974-81
pubmed: 2687331
J Immunol. 1996 Dec 1;157(11):5163-8
pubmed: 8943428
Curr Opin Organ Transplant. 2010 Aug;15(4):481-5
pubmed: 20613524
Am J Transplant. 2017 Jan;17(1):115-128
pubmed: 27343838
Transplantation. 1991 Sep;52(3):530-3
pubmed: 1716798
Clin Transplant. 2021 Jul;35(7):e14320
pubmed: 33864724
Eur J Immunol. 1992 May;22(5):1207-13
pubmed: 1577063
Eur J Immunol. 2004 Aug;34(8):2303-12
pubmed: 15259028
J Immunol. 2006 Nov 15;177(10):7355-63
pubmed: 17082655
Hum Immunol. 1997 Dec;58(2):91-105
pubmed: 9475338
EJNMMI Res. 2016 Dec;6(1):7
pubmed: 26801327
Transplantation. 2011 May 27;91(10):1103-9
pubmed: 21403588
Hum Immunol. 2011 Jan;72(1):5-10
pubmed: 20971146
Prog Allergy. 1988;40:44-81
pubmed: 3281171
J Immunol. 1997 Nov 15;159(10):4659-64
pubmed: 9366388
Transplantation. 2001 Mar 15;71(5):594-5
pubmed: 11292285
J Immunol. 1994 Oct 15;153(8):3791-803
pubmed: 7930596
Am J Transplant. 2010 Jan;10(1):149-56
pubmed: 19951279
Trends Biochem Sci. 2000 Aug;25(8):349-51
pubmed: 10916150
Dev Biol. 1989 Jun;133(2):515-28
pubmed: 2499495
Immunity. 2008 May;28(5):639-50
pubmed: 18482568
Arterioscler Thromb. 1992 Jul;12(7):836-42
pubmed: 1616909
J Cell Physiol. 1996 Sep;168(3):625-37
pubmed: 8816917