Gliflozin (SGLT2 inhibitor) induced vulvitis.
Journal
International journal of dermatology
ISSN: 1365-4632
Titre abrégé: Int J Dermatol
Pays: England
ID NLM: 0243704
Informations de publication
Date de publication:
Jan 2023
Jan 2023
Historique:
revised:
22
08
2022
received:
05
06
2022
accepted:
27
09
2022
pubmed:
18
10
2022
medline:
21
12
2022
entrez:
17
10
2022
Statut:
ppublish
Résumé
Sodium-glucose co-transporter 2 (SGLT2) inhibitors, or gliflozins, are used as mono or combined therapy in the management of diabetes. Genital infections are the most common reported adverse effect, as a result of induced glycosuria. Cutaneous features of patients experiencing vulval symptoms while on SGLT2 inhibitor therapy have not been clearly described in published literature. We have observed a specific inflammatory vulvitis with psoriasiform features in patients taking SGLT2 inhibitors, related to candidiasis in most cases. Demographic and treatment outcomes of 11 patients with characteristic inflammatory changes after starting SGLT2 inhibitors were extracted from electronic records. Ninety-one percent (n = 10) had candidiasis, treated with fluconazole. Six (54.5%) were able to continue SGLT-2 inhibitors through the addition of topical treatments, but five patients had to discontinue the drug. SGLT2 inhibitors can result in characteristic inflammatory vulvitis. Treatment with topical agents and single-dose antifungals may allow patients to continue their therapy to achieve improved glycemic control. In resistant cases, discontinuation of the drug is necessary. We highlight this effect so that early treatment can be initiated to alleviate symptoms and recognition of underlying cause.
Substances chimiques
Sodium-Glucose Transporter 2 Inhibitors
0
Hypoglycemic Agents
0
Sodium-Glucose Transporter 2
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
62-65Informations de copyright
© 2022 the International Society of Dermatology.
Références
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