A Bioinspired Orthopedic Biomaterial with Tunable Mechanical Properties Based on Sintered Titanium Fibers.
anisotropy
biometals
osseointegration
precision medicine
titanium fibers
Journal
Advanced healthcare materials
ISSN: 2192-2659
Titre abrégé: Adv Healthc Mater
Pays: Germany
ID NLM: 101581613
Informations de publication
Date de publication:
01 2023
01 2023
Historique:
received:
20
08
2022
pubmed:
18
10
2022
medline:
18
1
2023
entrez:
17
10
2022
Statut:
ppublish
Résumé
Inadequate mechanical compliance of orthopedic implants can result in excessive strain of the bone interface, and ultimately, aseptic loosening. It is hypothesized that a fiber-based biometal with adjustable anisotropic mechanical properties can reduce interface strain, facilitate continuous remodeling, and improve implant survival under complex loads. The biometal is based on strategically layered sintered titanium fibers. Six different topologies are manufactured. Specimens are tested under compression in three orthogonal axes under 3-point bending and torsion until failure. Biocompatibility testing involves murine osteoblasts. Osseointegration is investigated by micro-computed tomography and histomorphometry after implantation in a metaphyseal trepanation model in sheep. The material demonstrates compressive yield strengths of up to 50 MPa and anisotropy correlating closely with fiber layout. Samples with 75% porosity are both stronger and stiffer than those with 85% porosity. The highest bending modulus is found in samples with parallel fiber orientation, while the highest shear modulus is found in cross-ply layouts. Cell metabolism and morphology indicate uncompromised biocompatibility. Implants demonstrate robust circumferential osseointegration in vivo after 8 weeks. The biometal introduced in this study demonstrates anisotropic mechanical properties similar to bone, and excellent osteoconductivity and feasibility as an orthopedic implant material.
Identifiants
pubmed: 36250334
doi: 10.1002/adhm.202202106
doi:
Substances chimiques
Biocompatible Materials
0
titanium fiber
0
Titanium
D1JT611TNE
Trace Elements
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2202106Informations de copyright
© 2022 Wiley-VCH GmbH.
Références
J. Wang, T. Ishimoto, T. Nakano, Calcif. Tissue Int. 2017, 100, 87.
R. Oftadeh, M. Perez-Viloria, J. C. Villa-Camacho, A. Vaziri, A. Nazarian, J. Biomech. Eng. 2015, 137, 010802.
H. H. Bayraktar, E. F. Morgan, G. L. Niebur, G. E. Morris, E. K. Wong, T. M. Keaveny, J. Biomech. 2004, 37, 27.
E. Ozcivici, Y. K. Luu, B. Adler, Y.-X. Qin, J. Rubin, S. Judex, C. T. Rubin, Nat. Rev. Rheumatol. 2010, 6, 50.
T. Lang, J. J. W. A. Van Loon, S. Bloomfield, L. Vico, A. Chopard, J. Rittweger, A. Kyparos, D. Blottner, I. Vuori, R. Gerzer, P. R. Cavanagh, NPJ Microgravity 2017, 3, 8.
N. H. Hart, S. Nimphius, T. Rantalainen, A. Ireland, A. Siafarikas, R. U. Newton, J. Musculoskelet. Neuronal Interact. 2017, 17, 114.
A.-M. Pobloth, S. Checa, H. Razi, A. Petersen, J. C. Weaver, K. Schmidt-Bleek, M. Windolf, A. Ö. Tatai, C. P. Roth, K.-D. Schaser, G. N. Duda, P. Schwabe, Sci. Transl. Med. 2018, 10, eaam8828.
D. R. Epari, R. Gurung, L. Hofmann-Fliri, R. Schwyn, M. Schuetz, M. Windolf, J. Biomech. 2021, 115, 110192.
M. Long, H. J Rack, Biomaterials 1998, 19, 1621.
P. Ghensi, E. Bressan, C. Gardin, L. Ferroni, L. Ruffato, M. Caberlotto, C. Soldini, B. Zavan, Mater. Sci. Eng., C 2017, 74, 389.
I. Castellini, L. Andreani, P. D. Parchi, E. Bonicoli, N. Piolanti, F. Risoli, M. Lisanti, Clin. Cases Miner. Bone Metab. 2016, 13, 221.
M. D. Fabbro, S. Taschieri, E. Canciani, A. Addis, F. Musto, R. Weinstein, C. Dellavia, Implant Dent. 2017, 26, 357.
B. Ö. Malekzadeh, M. Ransjo, P. Tengvall, Z. Mladenovic, A. Westerlund, J. Biomed. Mater. Res., Part B 2017, 105, 1847.
M. Rüger, T. J. Gensior, C. Herren, M. V. Walter, C. Ocklenburg, R. Marx, H.-J. Erli, Acta Biomater. 2010, 6, 2852.
H. Uhthoff, D. Bardos, M. Liskova-Kiar, J. Bone Jt. Surg., Br. Vol. 1981, 63-B, 427.
C. A. Simmons, S. A. Meguid, R. M. Pilliar, J. Orthop. Res. 2001, 19, 187.
G. Ryan, A. Pandit, D. Apatsidis, Biomaterials 2006, 27, 2651.
V. Karageorgiou, D. Kaplan, Biomaterials 2005, 26, 5474.
M. Hanc, S. K. Fokter, M. Vogrin, A. Molicnik, G. Recnik, Eur. J. Orthop. Surg. 2016, 26, 1.
D. J. Cohen, A. Cheng, K. Sahingur, R. M. Clohessy, L. B. Hopkins, B. D. Boyan, Z. Schwartz, Biomed. Mater. 2017, 12, 025021.
X.-Y. Zhang, Addit. Manuf. 2020, 32, 1010.
B. Nagarajan, Z. Hu, Xu Song, W. Zhai, J. Wei, Engineering 2019, 5, 702.
T. M. Keaveny, E. F. Morgan, G. L. Niebur, O. C. Yeh, Annu. Rev. Biomed. Eng. 2001, 3, 307.
M. Nordin, V. H. Frankel, Basic Biomechanics of the Musculoskeletal System, 4th ed., Lippincott Williams & Wilkins, Philadelphia, PA 2013, p. 454.
A. Phillips, Eng. Comput. Mech. 2012, 165, 147.
K. M. Nuss, J. A. Auer, A. Boos, B. V. Rechenberg, BMC Musculoskeletal Disord. 2006, 7, 67.
J. Li, P. Habibovic, M. Vandendoel, C. Wilson, J. Dewijn, C. Vanblitterswijk, K. Degroot, Biomaterials 2007, 28, 2810.
J. Galante, W. Rostoker, J. Biomed. Mater. Res. 1973, 7, 43.
P. Ducheyne, Biomaterials 1983, 4, 185.
S. Li, Y.-W. Kim, M. Choi, T. Nam, Intermetallics 2019, 115, 106631.
T. Takizawa, N. Nakayama, H. Haniu, K. Aoki, M. Okamoto, H. Nomura, M. Tanaka, A. Sobajima, K. Yoshida, T. Kamanaka, K. Ajima, A. Oishi, C. Kuroda, H. Ishida, S. Okano, S. Kobayashi, H. Kato, N. Saito, Adv. Mater. 2018, 30, 1703608.
G. A. P. Renders, L. Mulder, L. J. Van Ruijven, T. M. G. J. Van Eijden, J. Anat. 2007, 210, 239.
M. von Salis-Soglio, S. Stübinger, M. Sidler, K. Klein, S. J. Ferguson, K. Kämpf, K. Zlinszky, S. Buchini, R. Curno, P. Péchy, B. O. Aronsson, B. von Rechenberg, J. Funct. Biomater. 2014, 5, 135.
J. D. Langhoff, K. Voelter, D. Scharnweber, M. Schnabelrauch, F. Schlottig, T. Hefti, K. Kalchofner, K. Nuss, B. Von Rechenberg, Int. J. Oral Surg. 2008, 37, 1125.