Effects of multi-kinase inhibitors on the activity of cytochrome P450 2J2.

Cytochrome P-450 Enzyme System
CYP2J2 Ki epoxyeicosatrienoic acid inhibition multi-kinase inhibitor

Journal

Xenobiotica; the fate of foreign compounds in biological systems
ISSN: 1366-5928
Titre abrégé: Xenobiotica
Pays: England
ID NLM: 1306665

Informations de publication

Date de publication:
Jul 2022
Historique:
pubmed: 18 10 2022
medline: 15 12 2022
entrez: 17 10 2022
Statut: ppublish

Résumé

1. Cytochrome P450 2J2 (CYP2J2) shows high expression in extrahepatic tissues, including the heart and kidney and in tumours. Inhibition of CYP2J2 has attracted attention for cancer treatment because it metabolises arachidonic acid (AA) to epoxyeicosatrienoic acid (EET), which inhibits apoptosis and promotes tumour growth. Multi-kinase inhibitor (MKI) is a molecular-targeted drug with antitumor activities. This study aimed to clarify the inhibitory effects of MKIs on CYP2J2 activity. We also investigated whether MKIs affected CYP2J2-catalysed EET formation from AA.2. Twenty MKIs showed different inhibitory potencies against astemizole

Identifiants

DOI: 10.1080/00498254.2022.2137068 PMID: 36251932
pubmed: 36251932
doi: 10.1080/00498254.2022.2137068
doi:

Substances chimiques

Cytochrome P-450 Enzyme System 9035-51-2

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

669-675

Auteurs

Ayaka Kojima (A)

Laboratory of Pharmaceutics, Faculty of Pharmacy, Meijo University, Nagoya, Japan.

Masayuki Nadai (M)

Laboratory of Pharmaceutics, Faculty of Pharmacy, Meijo University, Nagoya, Japan.

Norie Murayama (N)

Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Japan.

Hiroshi Yamazaki (H)

Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Japan.
ORCID: 0000-0002-1068-4261

Miki Katoh (M)

Laboratory of Pharmaceutics, Faculty of Pharmacy, Meijo University, Nagoya, Japan.
ORCID: 0000-0003-0825-6097

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Hémoprotéines › Cytochromes › Cytochrome P-450 enzyme system › Effects of multi-kinase inhibitors on the...