Diminished cortical bone density of long bones among children with haemophilic arthropathy.
Bone health
Bone mineral density
Children
Cortical bone density
Haemophilia joint health score
Quantitative ultrasound
Journal
Haemophilia : the official journal of the World Federation of Hemophilia
ISSN: 1365-2516
Titre abrégé: Haemophilia
Pays: England
ID NLM: 9442916
Informations de publication
Date de publication:
Jan 2023
Jan 2023
Historique:
revised:
19
08
2022
received:
18
04
2022
accepted:
04
10
2022
pubmed:
18
10
2022
medline:
25
1
2023
entrez:
17
10
2022
Statut:
ppublish
Résumé
Children with haemophilia (CwH) have lower bone mineral density in the spine (trabecular bone) than healthy children. There are few studies focusing on bone mineral density in long bones (cortical bone). To evaluate bi-laterally the distal third of radius and midshaft tibias using quantitative ultrasound (QUS) and assess the speed of sound (SoS). A cross-sectional study where 91 CwH and 91 age-matched healthy boys were included. Joint evaluation was determined with the Haemophilia Joint Health Score 2.1 and SoS values. The Z scores were measured with the Sunlight Omnisense 8000 S equipment. Ninety-one CwH (haemophilia A) were evaluated (26 mild form, 26 moderate, and 39 severe). Most patients were treated with on-demand factor replacement and had higher total HJHS scores according to severity (4.8, 14.8 and 14.1, respectively). Patients with moderate and severe disease showed a statistical difference in SoS values for both radius and tibias compared to controls. QUS Z-scores ≥-2 were more frequent in radius and tibias in CwH, but were statistically significant only in tibias when compared to controls (in 30% mild, 46% moderate, 28% severe, respectively). There was diminished cortical bone density in radius and tibias of CwH compared to healthy controls. Changes predominated in tibias, more frequently affected according to the severity of haemophilia. Early intervention with factor replacement combined with physical activity are key aspects to promote bone health.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
274-281Subventions
Organisme : SEP-CONACyT from the National Institute of Science and Technology (Consejo Nacional de Ciencia y Tecnología (CONACyT))
ID : SSA/IMSS/ISSSTE-CONACyT2010
Informations de copyright
© 2022 John Wiley & Sons Ltd.
Références
van Vulpen LFD, Holstein K, Martinoli C. Joint disease in haemophilia: pathophysiology, pain and imaging. Haemophilia. 2018;24:(Suppl 6):44-49.
Iorio A, Fabbriciani G, Marcucci M, Brozzetti M, Filipponi P. Bone mineral density in haemophilia patients. A meta-analysis. Thromb Haemost. 2010;103(3):596-603.
Paschou SA, Anagnostis P, Karras S, et al. Bone mineral density in men and children with haemophilia A and B: a systematic review and meta-analysis. Osteoporos Int. 2014;25(10):2399-2407.
Maggioli C, Stagi S. Bone modeling, remodeling, and skeletal health in children and adolescents: mineral accrual, assessment and treatment. Ann Pediatr Endocrinol Metab. 2017;22(1):1-5.
Golden NH, Abrams SA; Committee on nutrition. Optimizing bone health in children and adolescents. Pediatrics. 2014;134(4):e1229-e1243.
Hans D, Baim S. Quantitative ultrasound (QUS) in the management of osteoporosis and assessment of fracture risk. J Clin Densitom. 2017;20(3):322-333.
Dane C, Dane B, Cetin A, Erginbas M. The role of quantitative ultrasound in predicting osteoporosis defined by dual-energy X-ray absorptiometry in pre- and postmenopausal women. Climacteric. 2008;11(4):296-303.
Christoforidis A, Economu M, Papadopoulou E, et al. Bone status of children with hemophilia A assessed with quantitative ultrasound sonography (QUS) and dual energy X-ray absorptiometry (DXA). J Pediatr Hematol Oncol. 2010;32(7):e259-e263.
Christoforidis A, Economu M, Papadopoulou E, et al. Comparative study of dual energy X-ray absorptiometry and quantitative ultrasonography with the use of biochemical markers of bone turnover in boys with haemophilia. Haemophilia. 2011;17(1):e217-e222.
Tanner JM. Fetus into man: physical growth from conception to maturity. Revised edition. 1990. Cambridge, MA: Harvard University Press.
Rivas-Ruiz R, Clark P, Talavera JO, Huitron G, Tamayo JA, Salmeron J. Bone speed of sound throughout lifetime assessed with quantitative ultrasound in a Mexican population. J Clin Densitom. 2015;18(1):68-75.
Feldman BM, Funk SM, Bergstrom BM, et al. Validation of a new pediatric joint scoring system from the International Hemophilia Prophylaxis Study Group: validity of the hemophilia joint health score. Arthritis Care Res (Hoboken). 2011;63(2):223-230.
Gouw SC, Timmer MA, Srivastava A, et al. Measurement of joint health in persons with haemophilia: a systematic review of the measurement properties of haemophilia-specific instruments. Haemophilia. 2019;25(1):e1-e10.
Miller CH, Benson J, Ellingsen D, et al. F8 and F9 mutations in US haemophilia patients: correlation with history of inhibitor and race ethnicity. Haemophilia. 2012;18(3):375-382.
Villarreal-Martinez L, Garcia-Chavez J, Sanchez-Jara B, et al. Prevalence of inhibitors and clinical characteristics in patients with haemophilia in a middle-income Latin American country. Haemophilia. 2020;26(2):290-297.
Falk B, Portal S, Tiktinsky R, et al. Bone properties and muscle strength of young haemophilia patients. Haemophilia. 2005;11(4):380-386.
Manco-Johnson MJ, Boulden Warren B, Buckner TW, Funk SM, Wang M. Outcome measures in haemophilia: beyond ABR (annualized bleeding rate). Haemophilia. 2021;27:(Suppl 3):87-95.
Boban A, Zupancic Salek S, Kastelan D, Nemet D. Quantitative ultrasound and dual X-ray absorptiometry in the assessment of osteoporosis in patients with hemophilia. Haemophilia. 2014;20(6):e402-e422.
Naderi A, Nikvarz M, Arasteh M, Shokoohi M. Osteoporosis/osteopenia and hemophilic arthropathy in severely hemophilic patients. Arch Iran Med. 2012;15(2):82-84.
Ranta S, Viljakainen H, Makipernaa A, Makitie O. Peripheral quantitative computed tomography (pQCT) reveals alterations in the three dimensional bone structure in children with haemophilia. Haemophilia. 2012;18(6):955-961.
Soucek O, Komrska V, Hlavka Z, et al. Boys with haemophilia have low trabecular bone mineral density and sarcopenia, but normal bone strength at the radius. Haemophilia. 2012;18(2):222-228.
Xafaki P, Balanika A, Pergantou H, Papakonstantinou O, Platokouki H. Impact of target joint and FVIII inhibitor on bone properties in children with haemophilia A: A peripheral quantitative computed tomography study. Haemophilia. 2018;24(5):800-806.
Gualtierotti R, Solimeno LP, Peyvandi F. Hemophilic arthropathy: current knowledge and future perspectives. J Thromb Haemost. 2021;19(9):2112-2121.
Lee A, Boyd SK, Kline G, Poon MC. Premature changes in trabecular and cortical microarchitecture result in decreased bone strength in hemophilia. Blood. 2015;125(13):2160-2163.
Holstein K, Witt L, Matysiak A, et al. The bone microarchitecture deficit in patients with hemophilia is influenced by arthropathy, hepatitis C infection, and physical activity. Thromb Haemost. 2021;122(5):692-702 Sept 29. https://doi.org/10.1055/s-0041-1735964. Online ahead of print.
van Leeuwen J, Koes BW, Paulis WD, van Middelkoop M. Differences in bone mineral density between normal-weight children and children with overweight and obesity: a systematic review and meta-analysis. Obes Rev. 2017;18(5):526-546.
Zymbal V, Baptista F, Letuchy EM, Janz KF, Levy SM. Mediating effect of muscle on the relationship of physical activity and bone. Med Sci Sports Exerc. 2019;51(1):202-210.
Kempton CL, Antoniucci DM, Rodriguez-Merchan EC. Bone health in persons with haemophilia. Haemophilia. 2015;21(5):568-577.
Strike K, Mulder K, Michael R. Exercise for haemophilia. Cochrane Database Syst Rev. 2016;12(12):CD011180.
Petkovic MJ, Tran HA, Ebeling PR, Zengin A. Osteoporosis management and falls prevention in patients with haemophilia: review of haemophilia guidelines. Haemophilia. 2022;28(3):388-396 Mar 15. https://doi.org/10.1111/hae.14540. Online ahead of print.
Caviglia H, Landro ME, Galatro G, Candela M, Neme D. Epidemiology of fractures in patients with haemophilia. Injury. 2015;46(10):1885-1890.
Alam AU, Karhkaneh M, Attia T, Wu C, Sun HL. All-cause mortality and causes of death in persons with haemophilia: a systematic review and meta-analysis. Haemophilia. 2021;27(6):897-910.