A circulating subset of iNKT cells mediates antitumor and antiviral immunity.

Mice Humans Animals Natural Killer T-Cells / metabolism Interleukin-15 Antiviral Agents Granzymes Receptors, Natural Killer Cell Receptors, Chemokine / metabolism Lipids

Journal

Science immunology
ISSN: 2470-9468
Titre abrégé: Sci Immunol
Pays: United States
ID NLM: 101688624

Informations de publication

Date de publication:
28 10 2022
Historique:
entrez: 21 10 2022
pubmed: 22 10 2022
medline: 26 10 2022
Statut: ppublish

Résumé

Invariant natural killer T (iNKT) cells are a group of innate-like T lymphocytes that recognize lipid antigens. They are supposed to be tissue resident and important for systemic and local immune regulation. To investigate the heterogeneity of iNKT cells, we recharacterized iNKT cells in the thymus and peripheral tissues. iNKT cells in the thymus were divided into three subpopulations by the expression of the natural killer cell receptor CD244 and the chemokine receptor CXCR6 and designated as C0 (CD244

Identifiants

DOI: 10.1126/sciimmunol.abj8760 PMID: 36269840
pubmed: 36269840
doi: 10.1126/sciimmunol.abj8760
doi:

Substances chimiques

Interleukin-15 0
Antiviral Agents 0
Granzymes EC 3.4.21.-
Receptors, Natural Killer Cell 0
Receptors, Chemokine 0
Lipids 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

eabj8760

Auteurs

Guangwei Cui (G)

Laboratory of Immune Regulation, Department of Virus Research, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan.
ORCID: 0000-0002-3276-1926

Akihiro Shimba (A)

Laboratory of Immune Regulation, Department of Virus Research, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan.
Department of Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Jianshi Jin (J)

Laboratory for Prediction of Cell Systems Dynamics, RIKEN Center for Biosystems Dynamics Research (BDR) , Osaka, Japan.
ORCID: 0000-0003-4697-8760

Taisaku Ogawa (T)

Laboratory for Prediction of Cell Systems Dynamics, RIKEN Center for Biosystems Dynamics Research (BDR) , Osaka, Japan.

Yukiko Muramoto (Y)

Laboratory of Ultrastructural Virology, Department of Virus Research, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan.
ORCID: 0000-0002-8706-3113

Hitoshi Miyachi (H)

Reproductive Engineering Team, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan.
ORCID: 0000-0002-4855-3857

Shinya Abe (S)

Laboratory of Immune Regulation, Department of Virus Research, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan.
ORCID: 0000-0002-2707-1947

Takuma Asahi (T)

Laboratory of Immune Regulation, Department of Virus Research, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan.
Graduate School of Medicine, Kyoto University, Kyoto, Japan.
ORCID: 0000-0001-6372-7563

Shizue Tani-Ichi (S)

Laboratory of Immune Regulation, Department of Virus Research, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan.
Department of Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
ORCID: 0000-0003-2388-776X

Johannes M Dijkstra (JM)

Institute for Comprehensive Medical Science, Fujita Health University, Aichi, Japan.
ORCID: 0000-0001-7097-3826

Yayoi Iwamoto (Y)

Department of Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Kirill Kryukov (K)

Biomedical Informatics Laboratory, Department of Molecular Life Science, Tokai University, Kanagawa, Japan.
Biological Networks Laboratory, Department of Informatics, National Institute of Genetics, Shizuoka, Japan.
ORCID: 0000-0002-0286-0288

Yuanbo Zhu (Y)

Laboratory of Immune Regulation, Department of Virus Research, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan.

Daichi Takami (D)

Laboratory of Immune Regulation, Department of Virus Research, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan.
Graduate School of Pharmaceutical Science, Kyoto University, Kyoto, Japan.

Takahiro Hara (T)

Laboratory of Immune Regulation, Department of Virus Research, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan.

Satsuki Kitano (S)

Reproductive Engineering Team, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan.
ORCID: 0000-0003-2628-5991

Yan Xu (Y)

Medical Innovation Center, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
ORCID: 0000-0002-7036-0867

Hajime Morita (H)

Department of Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Moyu Zhang (M)

Department of Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Lynn Zreka (L)

Department of Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Keishi Miyata (K)

Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
ORCID: 0000-0003-0336-1859

Takashi Kanaya (T)

Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.

Shinya Okumura (S)

Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Takashi Ito (T)

Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
ORCID: 0000-0002-5892-8317

Etsuro Hatano (E)

Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
ORCID: 0000-0003-3407-1918

Yoshimasa Takahashi (Y)

Research Center for Drug and Vaccine Development, National Institute of Infectious Diseases, Tokyo, Japan.

Hiroshi Watarai (H)

Department of Immunology and Stem Cell Biology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Ishikawa, Japan.

Yuichi Oike (Y)

Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.

Tadashi Imanishi (T)

Biomedical Informatics Laboratory, Department of Molecular Life Science, Tokai University, Kanagawa, Japan.
ORCID: 0000-0002-1182-9127

Hiroshi Ohno (H)

Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.
ORCID: 0000-0001-8776-9661

Toshiaki Ohteki (T)

Department of Biodefense Research, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.

Nagahiro Minato (N)

Medical Innovation Center, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Masato Kubo (M)

Laboratory for Cytokine Regulation, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.
Division of Molecular Pathology, Research Institute for Biomedical Science, Tokyo University of Science, Chiba, Japan.
ORCID: 0000-0001-7867-3086

Georg A Holländer (GA)

Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Pediatric Immunology, Department of Biomedicine, University of Basel and University Children's Hospital Basel, Basel, Switzerland.
Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.
ORCID: 0000-0002-8790-0874

Hideki Ueno (H)

Department of Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
ORCID: 0000-0001-7747-0738

Takeshi Noda (T)

Laboratory of Ultrastructural Virology, Department of Virus Research, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan.
ORCID: 0000-0002-0658-4663

Katsuyuki Shiroguchi (K)

Laboratory for Prediction of Cell Systems Dynamics, RIKEN Center for Biosystems Dynamics Research (BDR) , Osaka, Japan.
ORCID: 0000-0003-4025-8789

Koichi Ikuta (K)

Laboratory of Immune Regulation, Department of Virus Research, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan.
ORCID: 0000-0003-1319-1021

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › A circulating subset of iNKT cells mediates...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A circulating subset of iNKT cells mediates...
questionsmedicales.fr › Eucaryotes › Animaux › A circulating subset of iNKT cells mediates...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Cellules T tueuses naturelles › A circulating subset of iNKT cells mediates...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-15 › A circulating subset of iNKT cells mediates...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiviraux › A circulating subset of iNKT cells mediates...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Protéases à sérine › Serine endopeptidases › Granzymes › A circulating subset of iNKT cells mediates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs de cellules tueuses naturelles › A circulating subset of iNKT cells mediates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux cytokines › Récepteurs aux chimiokines › A circulating subset of iNKT cells mediates...
questionsmedicales.fr › Lipides › A circulating subset of iNKT cells mediates...