VaporSPOT: Parallel Synthesis of Oligosaccharides on Membranes.
Journal
Journal of the American Chemical Society
ISSN: 1520-5126
Titre abrégé: J Am Chem Soc
Pays: United States
ID NLM: 7503056
Informations de publication
Date de publication:
02 11 2022
02 11 2022
Historique:
pubmed:
22
10
2022
medline:
4
11
2022
entrez:
21
10
2022
Statut:
ppublish
Résumé
Automated chemical synthesis has revolutionized synthetic access to biopolymers in terms of simplicity and speed. While automated oligosaccharide synthesis has become faster and more versatile, the parallel synthesis of oligosaccharides is not yet possible. Here, a chemical vapor glycosylation strategy (VaporSPOT) is described that enables the simultaneous synthesis of oligosaccharides on a cellulose membrane solid support. Different linkers allow for flexible and straightforward cleavage, purification, and characterization of the target oligosaccharides. This method is the basis for the development of parallel automated glycan synthesis platforms.
Identifiants
pubmed: 36269942
doi: 10.1021/jacs.2c07285
pmc: PMC9634802
doi:
Substances chimiques
Oligosaccharides
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
19832-19837Références
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