Hippocampal activity during memory and visual perception: The role of representational content.
Hippocampus
MRI
Memory
Perception
Representational models
Journal
Cortex; a journal devoted to the study of the nervous system and behavior
ISSN: 1973-8102
Titre abrégé: Cortex
Pays: Italy
ID NLM: 0100725
Informations de publication
Date de publication:
12 2022
12 2022
Historique:
received:
27
05
2022
revised:
30
07
2022
accepted:
05
09
2022
pubmed:
23
10
2022
medline:
15
12
2022
entrez:
22
10
2022
Statut:
ppublish
Résumé
The functional organisation of the medial temporal lobe (MTL) has long been described on the basis of cognitive processes such as recollection or familiarity. However, this view has recently been challenged, and researchers have proposed decomposing cognitive phenomena into representations and operations. According to the representational view, representations, such as scenes for the hippocampus and objects for the perirhinal cortex, are critical in understanding the role of MTL regions in cognition. In the present study, 51 healthy young participants underwent functional magnetic resonance imaging (fMRI) while completing a visual-discrimination task. Subsequently, half of the participants performed a patch-cue recognition procedure in which "Rec" responses are believed to reflect the operation of pattern completion, whereas the other half performed a whole-item remember/know procedure. We replicated the previously-reported demonstration that hippocampal involvement in pattern completion is preferential for scenes as compared with objects. In contrast, the perirhinal cortex was more recruited for object processing than for scene processing. We further extended these results to the operations of strength-signal memory and visual discrimination. Finally, the modulation of hippocampal engagement in pattern completion by representational content was found to be specific to its anterior segment. This observation is consistent with the proposal that this segment would process broad/global representations, whereas the posterior hippocampus would perform sharp/local representations. Taken together, these results favour the representational view of MTL functional organisation, but support that this specialisation differs along the hippocampal long-axis.
Identifiants
pubmed: 36272329
pii: S0010-9452(22)00256-8
doi: 10.1016/j.cortex.2022.09.004
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
14-29Informations de copyright
Copyright © 2022 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Conflict of interest The authors declare that no conflict of interest exists.