Metabolic clearance of oxaloacetate and mitochondrial complex II respiration: Divergent control in skeletal muscle and brown adipose tissue.
Brown adipose tissue
Mitochondria
Mitochondrial complex II
Muscle
Oxaloacetate
Succinate dehydrogenase
Journal
Biochimica et biophysica acta. Bioenergetics
ISSN: 1879-2650
Titre abrégé: Biochim Biophys Acta Bioenerg
Pays: Netherlands
ID NLM: 101731706
Informations de publication
Date de publication:
01 01 2023
01 01 2023
Historique:
received:
31
03
2022
revised:
10
08
2022
accepted:
12
10
2022
pubmed:
23
10
2022
medline:
25
2
2023
entrez:
22
10
2022
Statut:
ppublish
Résumé
At low inner mitochondrial membrane potential (ΔΨ) oxaloacetate (OAA) accumulates in the organelles concurrently with decreased complex II-energized respiration. This is consistent with ΔΨ-dependent OAA inhibition of succinate dehydrogenase. To assess the metabolic importance of this process, we tested the hypothesis that perturbing metabolic clearance of OAA in complex II-energized mitochondria would alter O
Identifiants
pubmed: 36272463
pii: S0005-2728(22)00400-5
doi: 10.1016/j.bbabio.2022.148930
pmc: PMC10225247
mid: NIHMS1898125
pii:
doi:
Substances chimiques
Oxaloacetic Acid
2F399MM81J
Succinate Dehydrogenase
EC 1.3.99.1
Pyruvic Acid
8558G7RUTR
Succinic Acid
AB6MNQ6J6L
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
148930Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK104998
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK123043
Pays : United States
Informations de copyright
Published by Elsevier B.V.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no conflicts of interest with the contents of this article.
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