Sex Hormones in Breast Cancer Immunity.
Journal
Cancer research
ISSN: 1538-7445
Titre abrégé: Cancer Res
Pays: United States
ID NLM: 2984705R
Informations de publication
Date de publication:
04 01 2023
04 01 2023
Historique:
received:
03
06
2022
revised:
22
09
2022
accepted:
18
10
2022
pubmed:
25
10
2022
medline:
6
1
2023
entrez:
24
10
2022
Statut:
ppublish
Résumé
Sex hormones, such as estrogens and androgens, regulate genomic and cellular processes that contribute to sex-specific disparities in the pathophysiology of various cancers. Sex hormones can modulate the immune signals and activities of tumor cells and tumor-associated leukocytes to support or suppress cancer progression. Therefore, hormonal differences between males and females play a crucial role in cancer immunity and in the response to therapies that exploit the intrinsic immune system to eliminate malignant cells. In this review, we summarize the impact of sex hormones in the breast cancer microenvironment, with a focus on how the hormonal environment affects tumor immunity. We also discuss the potential benefits of endocrine therapy used in combination with immunotherapy to strengthen the antitumor immune response.
Identifiants
pubmed: 36279153
pii: 711843
doi: 10.1158/0008-5472.CAN-22-1829
doi:
Substances chimiques
Gonadal Steroid Hormones
0
Estrogens
0
Androgens
0
Types de publication
Review
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
12-19Informations de copyright
©2022 American Association for Cancer Research.