Mechanistic perspectives on anti-aminoacyl-tRNA synthetase syndrome.
HisRS
WHEP domain
autoantigen
extracellular vesicle
immune complex
tRNA
Journal
Trends in biochemical sciences
ISSN: 0968-0004
Titre abrégé: Trends Biochem Sci
Pays: England
ID NLM: 7610674
Informations de publication
Date de publication:
03 2023
03 2023
Historique:
received:
01
06
2022
revised:
28
09
2022
accepted:
29
09
2022
pmc-release:
01
03
2024
pubmed:
25
10
2022
medline:
25
2
2023
entrez:
24
10
2022
Statut:
ppublish
Résumé
Antisynthetase syndrome (ASSD) is an autoimmune disease characterized by circulating autoantibodies against one of eight aminoacyl-tRNA synthetases (aaRSs). Although these autoantibodies are believed to play critical roles in ASSD pathogenesis, the nature of their roles remains unclear. Here we describe ASSD pathogenesis and discuss ASSD-linked aaRSs - from the WHEP domain that may impart immunogenicity to the role of tRNA in eliciting the innate immune response and the secretion of aaRSs from cells. Through these explorations, we propose that ASSD pathogenesis involves the tissue-specific secretion of aaRSs and that extracellular tRNAs or tRNA fragments and their ability to engage Toll-like receptor signaling may be important disease factors.
Identifiants
pubmed: 36280495
pii: S0968-0004(22)00270-5
doi: 10.1016/j.tibs.2022.09.011
pmc: PMC9974581
mid: NIHMS1840086
pii:
doi:
Substances chimiques
Amino Acyl-tRNA Synthetases
EC 6.1.1.-
RNA, Transfer
9014-25-9
Autoantibodies
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
288-302Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM139627
Pays : United States
Informations de copyright
Copyright © 2022 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors have no interests to declare.
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