CD8
Journal
Nature neuroscience
ISSN: 1546-1726
Titre abrégé: Nat Neurosci
Pays: United States
ID NLM: 9809671
Informations de publication
Date de publication:
11 2022
11 2022
Historique:
received:
08
11
2021
accepted:
14
09
2022
pubmed:
26
10
2022
medline:
5
11
2022
entrez:
25
10
2022
Statut:
ppublish
Résumé
A hallmark of nervous system aging is a decline of white matter volume and function, but the underlying mechanisms leading to white matter pathology are unknown. In the present study, we found age-related alterations of oligodendrocyte cell state with a reduction in total oligodendrocyte density in aging murine white matter. Using single-cell RNA-sequencing, we identified interferon (IFN)-responsive oligodendrocytes, which localize in proximity to CD8
Identifiants
pubmed: 36280798
doi: 10.1038/s41593-022-01183-6
pii: 10.1038/s41593-022-01183-6
pmc: PMC9630119
doi:
Substances chimiques
Interferons
9008-11-1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1446-1457Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2022. The Author(s).
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