Nucleoside transporters and immunosuppressive adenosine signaling in the tumor microenvironment: Potential therapeutic opportunities.
Adenosine
Drug
Immunosuppression
Nucleoside
Receptor
Signaling
Transporter
Journal
Pharmacology & therapeutics
ISSN: 1879-016X
Titre abrégé: Pharmacol Ther
Pays: England
ID NLM: 7905840
Informations de publication
Date de publication:
12 2022
12 2022
Historique:
received:
05
07
2022
revised:
17
10
2022
accepted:
19
10
2022
pubmed:
26
10
2022
medline:
7
12
2022
entrez:
25
10
2022
Statut:
ppublish
Résumé
Adenosine compartmentalization has a profound impact on immune cell function by regulating adenosine localization and, therefore, extracellular signaling capabilities, which suppresses immune cell function in the tumor microenvironment. Nucleoside transporters, responsible for the translocation and cellular compartmentalization of hydrophilic adenosine, represent an understudied yet crucial component of adenosine disposition in the tumor microenvironment. In this review article, we will summarize what is known regarding nucleoside transporter's function within the purinome in relation to currently devised points of intervention (i.e., ectonucleotidases, adenosine receptors) for cancer immunotherapy, alterations in nucleoside transporter expression reported in cancer, and potential avenues for targeting of nucleoside transporters for the desired modulation of adenosine compartmentalization and action. Further, we put forward that nucleoside transporters are an unexplored therapeutic opportunity, and modulation of nucleoside transport processes could attenuate the pathogenic buildup of immunosuppressive adenosine in solid tumors, particularly those enriched with nucleoside transport proteins.
Identifiants
pubmed: 36283452
pii: S0163-7258(22)00194-2
doi: 10.1016/j.pharmthera.2022.108300
pmc: PMC10290419
mid: NIHMS1907564
pii:
doi:
Substances chimiques
Nucleoside Transport Proteins
0
Adenosine
K72T3FS567
Nucleosides
0
Receptors, Purinergic P1
0
Immunosuppressive Agents
0
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
108300Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM143217
Pays : United States
Organisme : NCI NIH HHS
ID : R03 CA262490
Pays : United States
Informations de copyright
Published by Elsevier Inc.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare no potential conflict of interests.
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