Stepwise progression of β-selection during T cell development involves histone deacetylation.
Journal
Life science alliance
ISSN: 2575-1077
Titre abrégé: Life Sci Alliance
Pays: United States
ID NLM: 101728869
Informations de publication
Date de publication:
01 2023
01 2023
Historique:
received:
03
08
2022
revised:
02
10
2022
accepted:
04
10
2022
entrez:
25
10
2022
pubmed:
26
10
2022
medline:
28
10
2022
Statut:
epublish
Résumé
During T cell development, the first step in creating a unique T cell receptor (TCR) is genetic recombination of the TCRβ chain. The quality of the new TCRβ is assessed at the β-selection checkpoint. Most cells fail this checkpoint and die, but the coordination of fate at the β-selection checkpoint is not yet understood. We shed new light on fate determination during β-selection using a selective inhibitor of histone deacetylase 6, ACY1215. ACY1215 disrupted the β-selection checkpoint. Characterising the basis for this disruption revealed a new, pivotal stage in β-selection, bookended by up-regulation of TCR co-receptors, CD28 and CD2, respectively. Within this "DN3b
Identifiants
pubmed: 36283704
pii: 6/1/e202201645
doi: 10.26508/lsa.202201645
pmc: PMC9595210
pii:
doi:
Substances chimiques
CD28 Antigens
0
Receptors, Antigen, T-Cell, alpha-beta
0
Histones
0
Histone Deacetylase 6
EC 3.5.1.98
Receptors, Antigen, T-Cell
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2022 Chann et al.
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