Toxic Occupational Exposures and Membranous Nephropathy.

Female Humans Male Asbestos Autoantibodies Epitopes Glomerulonephritis, Membranous / epidemiology Occupational Exposure / adverse effects Receptors, Phospholipase A2 Solvents
membranous nephropathy nephrotic syndrome occupational exposure

Journal

Clinical journal of the American Society of Nephrology : CJASN
ISSN: 1555-905X
Titre abrégé: Clin J Am Soc Nephrol
Pays: United States
ID NLM: 101271570

Informations de publication

Date de publication:
11 2022
Historique:
received: 09 03 2022
accepted: 20 09 2022
pubmed: 26 10 2022
medline: 10 11 2022
entrez: 25 10 2022
Statut: ppublish

Résumé

Membranous nephropathy is a rare autoimmune kidney disease whose increasing prevalence in industrialized countries pleads for the involvement of an environmental factor in the development of the disease. In addition, the predominance of men in membranous nephropathy, classically attributed to biologic or genetic differences between men and women, could also be due to different occupational exposures. To support this hypothesis, we sought to describe the toxic occupational exposures of patients with membranous nephropathy. In this observational epidemiologic study, we compared the occupations and toxic occupational exposures of 100 patients with membranous nephropathy with those of the general population, consisting of two cohorts of 26,734,000 and 26,500 French workers. We then compared the characteristics of patients exposed to an occupational toxic substance with those of unexposed patients. Patients with membranous nephropathy worked more frequently in the construction sector than the general population (33% versus 7%, Patients with membranous nephropathy were more frequently exposed to certain occupational toxic substances, such as asbestos and organic solvents, than the general population. This occupational exposure was more frequent in men and in patients with PLA2R1 epitope spreading. Immunopathological Analysis in a French National Cohort of Membranous Nephropathy (IHMN), NCT04326218. This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2022_10_25_CJN02930322.mp3.

Sections du résumé

BACKGROUND AND OBJECTIVES
Membranous nephropathy is a rare autoimmune kidney disease whose increasing prevalence in industrialized countries pleads for the involvement of an environmental factor in the development of the disease. In addition, the predominance of men in membranous nephropathy, classically attributed to biologic or genetic differences between men and women, could also be due to different occupational exposures. To support this hypothesis, we sought to describe the toxic occupational exposures of patients with membranous nephropathy.
DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS
In this observational epidemiologic study, we compared the occupations and toxic occupational exposures of 100 patients with membranous nephropathy with those of the general population, consisting of two cohorts of 26,734,000 and 26,500 French workers. We then compared the characteristics of patients exposed to an occupational toxic substance with those of unexposed patients.
RESULTS
Patients with membranous nephropathy worked more frequently in the construction sector than the general population (33% versus 7%,
CONCLUSIONS
Patients with membranous nephropathy were more frequently exposed to certain occupational toxic substances, such as asbestos and organic solvents, than the general population. This occupational exposure was more frequent in men and in patients with PLA2R1 epitope spreading.
CLINICAL TRIAL REGISTRY NAME AND REGISTRATION NUMBER
Immunopathological Analysis in a French National Cohort of Membranous Nephropathy (IHMN), NCT04326218.
PODCAST
This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2022_10_25_CJN02930322.mp3.

Identifiants

DOI: 10.2215/CJN.02930322 PMID: 36283759 PMC: PMC9718038
pubmed: 36283759
pii: 01277230-202211000-00008
doi: 10.2215/CJN.02930322
pmc: PMC9718038
doi:

Substances chimiques

Asbestos 1332-21-4
Autoantibodies 0
Epitopes 0
PLA2R1 protein, human 0
Receptors, Phospholipase A2 0
Solvents 0

Banques de données

ClinicalTrials.gov
['NCT04326218']

Types de publication

Journal Article Observational Study Webcast Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1609-1619

Informations de copyright

Copyright © 2022 by the American Society of Nephrology.

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Auteurs

Marion Cremoni (M)

Reference Center for Rare Diseases Idiopathic Nephrotic Syndrome, Nice University Hospital, Nice, France.
Clinical Research Unit Côte d'Azur, University Côte d'Azur, Nice, France.
Department of Nephrology Dialysis and Transplantation, Pasteur 2 Hospital, Nice University Hospital, Nice, France.
ORCID: 0000-0002-5837-9469

Sophie Agbekodo (S)

Department of Occupational Health, Cimiez Hospital, Nice University Hospital, Nice, France.

Maxime Teisseyre (M)

Reference Center for Rare Diseases Idiopathic Nephrotic Syndrome, Nice University Hospital, Nice, France.
Clinical Research Unit Côte d'Azur, University Côte d'Azur, Nice, France.

Kevin Zorzi (K)

Reference Center for Rare Diseases Idiopathic Nephrotic Syndrome, Nice University Hospital, Nice, France.

Vesna Brglez (V)

Reference Center for Rare Diseases Idiopathic Nephrotic Syndrome, Nice University Hospital, Nice, France.
Clinical Research Unit Côte d'Azur, University Côte d'Azur, Nice, France.

Sylvia Benzaken (S)

Immunology Laboratory, Archet 1 Hospital, Nice University Hospital, Nice, France.

Vincent Esnault (V)

Reference Center for Rare Diseases Idiopathic Nephrotic Syndrome, Nice University Hospital, Nice, France.
Department of Nephrology Dialysis and Transplantation, Pasteur 2 Hospital, Nice University Hospital, Nice, France.

Jo-Hanna Planchard (JH)

Department of Occupational Health, Cimiez Hospital, Nice University Hospital, Nice, France.

Barbara Seitz-Polski (B)

Reference Center for Rare Diseases Idiopathic Nephrotic Syndrome, Nice University Hospital, Nice, France seitz-polski.b@chu-nice.fr.
Clinical Research Unit Côte d'Azur, University Côte d'Azur, Nice, France.
Department of Nephrology Dialysis and Transplantation, Pasteur 2 Hospital, Nice University Hospital, Nice, France.
Immunology Laboratory, Archet 1 Hospital, Nice University Hospital, Nice, France.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Toxic Occupational Exposures and Membranous...
questionsmedicales.fr › Produits chimiques inorganiques › Composés du silicium › Silice › Acide silicique › Silicates › Amiante › Toxic Occupational Exposures and Membranous...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Autoanticorps › Toxic Occupational Exposures and Membranous...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Épitopes › Toxic Occupational Exposures and Membranous...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Glomérulonéphrite extra-membraneuse › Toxic Occupational Exposures and Membranous...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pollution de l'environnement › Exposition environnementale › Exposition professionnelle › Toxic Occupational Exposures and Membranous...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs à la phospholipase A2 › Toxic Occupational Exposures and Membranous...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Solvants › Toxic Occupational Exposures and Membranous...