Basal cell carcinomas in organ transplant recipients versus the general population: clinicopathologic study.
Basal cell carcinoma
Histopathology
Immunosuppression
Organ transplant recipients
Skin cancer
Journal
Archives of dermatological research
ISSN: 1432-069X
Titre abrégé: Arch Dermatol Res
Pays: Germany
ID NLM: 8000462
Informations de publication
Date de publication:
May 2023
May 2023
Historique:
received:
06
04
2022
accepted:
11
10
2022
revised:
21
09
2022
medline:
12
4
2023
pubmed:
26
10
2022
entrez:
25
10
2022
Statut:
ppublish
Résumé
Organ transplant recipients (OTRs) are at greater risk of basal cell carcinomas (BCCs) than non-OTRs, but histopathologic differences between BCCs in OTRs and the general population are largely unknown. We compared clinicopathologic features of BCCs in OTRs vs the general population in Queensland, Australia. Details of BCC tumors (site, size, level of invasion, subtype, biopsy procedure) were collected from histopathology reports in two prospective skin cancer studies, one in OTRs and one general-population-based. We used log-binomial regression models to estimate age- and sex-adjusted prevalence ratios (PR) with 95% confidence intervals (CIs) for BCC features. Overall, there were 702 BCCs in 200 OTRs and 1725 BCCs in 804 population cases. Of these, 327 tumors in 128 OTRs were higher risk BCCs (any head and neck BCC; ≥ 2 cm on trunk/extremities), more per person than 703 higher risk BCCs in 457 cases in the general population (chi-square p = 0.008). Among head/neck BCCs, OTRs were more likely than general population cases to have BCCs on scalp/ear than on face/lip/neck (PR = 1.5, 95%CI 1.2-1.8). Although aggressive subtypes were less common among higher risk BCCs in OTRs, BCCs invading beyond the dermis were almost twice as prevalent in OTRs (PR = 1.8, 95% CI 1.3-2.6) than the general population.
Identifiants
pubmed: 36283992
doi: 10.1007/s00403-022-02403-6
pii: 10.1007/s00403-022-02403-6
pmc: PMC10085887
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
771-777Subventions
Organisme : National Health and Medical Research Council
ID : 552429
Informations de copyright
© 2022. The Author(s).
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