Vitamin D
ageing
skin
varicella zoster virus
vitamin D
Journal
Immunotherapy advances
ISSN: 2732-4303
Titre abrégé: Immunother Adv
Pays: England
ID NLM: 101776979
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
received:
20
10
2020
revised:
12
11
2020
accepted:
19
11
2020
entrez:
26
10
2022
pubmed:
25
11
2020
medline:
25
11
2020
Statut:
epublish
Résumé
Ageing is associated with increased number of infections, decreased vaccine efficacy and increased systemic inflammation termed inflammageing. These changes are reflected by reduced recall responses to varicella zoster virus (VZV) challenge in the skin of older adults. Vitamin D deficiency is more common in the old and has been associated with frailty and increased inflammation. In addition, vitamin D increases immunoregulatory mechanisms and therefore has the potential to inhibit inflammageing. We investigated the use of vitamin D Vitamin D insufficient older adults ( We showed that older adults had reduced VZV-specific cutaneous immune response and increased non-specific inflammation as compared to young. Increased non-specific inflammation observed in the skin of older adults negatively correlated with vitamin D sufficiency. We showed that vitamin D Vitamin D
Identifiants
pubmed: 36284901
doi: 10.1093/immadv/ltaa008
pii: ltaa008
pmc: PMC9585673
doi:
Types de publication
Journal Article
Langues
eng
Pagination
ltaa008Subventions
Organisme : Medical Research Council
ID : MR/M003833/1
Pays : United Kingdom
Informations de copyright
© The Author(s) 2020. Published by Oxford University Press on behalf of the British Society for Immunology.
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